SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hu8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 7 SER A 428
GLY A 200
HIS A 201
ILE A 198
 None
None
GOL  A 502 (-3.9A)
None
 0.93A 1gtnF-4hu8A:
undetectable
1gtnG-4hu8A:
undetectable		 1gtnF-4hu8A:
10.91
1gtnG-4hu8A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 7 SER A 428
GLY A 200
HIS A 201
ILE A 198
 None
None
GOL  A 502 (-3.9A)
None
 0.97A 1gtnJ-4hu8A:
undetectable
1gtnK-4hu8A:
undetectable		 1gtnJ-4hu8A:
10.91
1gtnK-4hu8A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		5 / 12 GLU A 419
LEU A 416
ARG A 354
ILE A 423
TYR A 467
 None
 1.31A 1l7fA-4hu8A:
undetectable		 1l7fA-4hu8A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		5 / 12 GLU A 419
LEU A 416
ARG A 354
ILE A 423
TYR A 467
 None
 1.31A 1l7hA-4hu8A:
undetectable		 1l7hA-4hu8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 6 TYR A 360
ILE A 335
TYR A 298
GLY A 339
 None
 1.14A 1maaB-4hu8A:
undetectable
1maaD-4hu8A:
undetectable		 1maaB-4hu8A:
20.11
1maaD-4hu8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 8 LEU A 148
LYS A 454
MET A 429
GLY A 431
 None
 1.01A 1os6A-4hu8A:
undetectable		 1os6A-4hu8A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		3 / 3 TRP A 438
VAL A 432
TRP A 430
 GOL  A 502 (-4.0A)
None
GOL  A 502 ( 4.4A)
 1.22A 2xdcC-4hu8A:
undetectable
2xdcD-4hu8A:
undetectable		 2xdcC-4hu8A:
6.59
2xdcD-4hu8A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		3 / 3 TRP A 438
VAL A 432
TRP A 430
 GOL  A 502 (-4.0A)
None
GOL  A 502 ( 4.4A)
 1.23A 2xdcE-4hu8A:
undetectable
2xdcF-4hu8A:
undetectable		 2xdcE-4hu8A:
6.59
2xdcF-4hu8A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		3 / 3 TRP A 438
VAL A 432
TRP A 430
 GOL  A 502 (-4.0A)
None
GOL  A 502 ( 4.4A)
 1.24A 2y5mE-4hu8A:
undetectable
2y5mF-4hu8A:
undetectable		 2y5mE-4hu8A:
6.59
2y5mF-4hu8A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		3 / 3 TRP A 438
VAL A 432
TRP A 430
 GOL  A 502 (-4.0A)
None
GOL  A 502 ( 4.4A)
 1.24A 2y6nC-4hu8A:
undetectable
2y6nD-4hu8A:
undetectable		 2y6nC-4hu8A:
6.59
2y6nD-4hu8A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		3 / 3 TRP A 438
VAL A 432
TRP A 430
 GOL  A 502 (-4.0A)
None
GOL  A 502 ( 4.4A)
 1.24A 2y6nE-4hu8A:
undetectable
2y6nF-4hu8A:
undetectable		 2y6nE-4hu8A:
6.59
2y6nF-4hu8A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		5 / 12 SER A 370
HIS A 199
TYR A 298
VAL A 365
GLY A 337
 None
 1.42A 3f8wB-4hu8A:
undetectable		 3f8wB-4hu8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 6 ILE A 252
HIS A 206
LEU A 249
ASP A 300
 None
 1.22A 3oi8A-4hu8A:
undetectable		 3oi8A-4hu8A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 8 LEU A 148
LYS A 454
MET A 429
GLY A 431
 None
 0.99A 3selX-4hu8A:
undetectable		 3selX-4hu8A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		5 / 12 GLY A 441
GLY A 387
ILE A 397
ALA A 390
ASP A 394
 None
 1.05A 4a6dA-4hu8A:
undetectable		 4a6dA-4hu8A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		5 / 12 GLY A 441
GLY A 387
ILE A 397
ALA A 390
ASP A 394
 None
 1.06A 4a6eA-4hu8A:
undetectable		 4a6eA-4hu8A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		3 / 3 HIS A 199
GLU A 371
ASN A 250
 None
GOL  A 502 (-2.5A)
GOL  A 502 (-3.4A)
 1.04A 4bupB-4hu8A:
undetectable		 4bupB-4hu8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 7 ARG A 426
TRP A 246
ASN A 299
TYR A 284
 None
None
GOL  A 502 (-4.6A)
None
 1.23A 4f8yC-4hu8A:
undetectable
4f8yD-4hu8A:
undetectable		 4f8yC-4hu8A:
18.20
4f8yD-4hu8A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		5 / 12 GLU A 419
LEU A 416
ARG A 354
ILE A 423
TYR A 467
 None
 1.30A 4mwvA-4hu8A:
undetectable		 4mwvA-4hu8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		3 / 3 SER A 437
ASP A 434
GLN A 406
 None
 0.75A 4oltA-4hu8A:
undetectable
4oltB-4hu8A:
undetectable		 4oltA-4hu8A:
21.99
4oltB-4hu8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		3 / 3 GLN A 406
SER A 437
ASP A 434
 None
 0.71A 4qwpA-4hu8A:
undetectable
4qwpB-4hu8A:
undetectable		 4qwpA-4hu8A:
21.99
4qwpB-4hu8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		3 / 3 VAL A 432
SER A 433
TRP A 147
 None
 1.01A 5jwaA-4hu8A:
undetectable		 5jwaA-4hu8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		3 / 3 LYS A 409
GLN A 305
ASN A 352
 None
 0.98A 5l2tA-4hu8A:
undetectable		 5l2tA-4hu8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 4 SER A  59
ALA A  58
GLN A  31
THR A 105
 None
 1.23A 5n0rA-4hu8A:
undetectable		 5n0rA-4hu8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 4 SER A  59
ALA A  58
GLN A  31
THR A 105
 None
 1.25A 5n0sA-4hu8A:
undetectable		 5n0sA-4hu8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 5 SER A  59
ALA A  58
GLN A  31
THR A 105
 None
 1.26A 5n0tA-4hu8A:
undetectable		 5n0tA-4hu8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 4 SER A  59
ALA A  58
GLN A  31
THR A 105
 None
 1.22A 5n0wA-4hu8A:
undetectable		 5n0wA-4hu8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 5 SER A  59
ALA A  58
GLN A  31
THR A 105
 None
 1.20A 5n0wB-4hu8A:
undetectable		 5n0wB-4hu8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 4 SER A  59
ALA A  58
GLN A  31
THR A 105
 None
 1.21A 5n0xA-4hu8A:
undetectable		 5n0xA-4hu8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		3 / 3 SER A  59
ALA A  58
THR A 105
 None
 0.74A 5n0xB-4hu8A:
undetectable		 5n0xB-4hu8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 5 SER A  59
ALA A  58
GLN A  31
THR A 105
 None
 1.21A 5n4iA-4hu8A:
undetectable		 5n4iA-4hu8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 4 ARG A 266
ILE A 252
TYR A 298
ILE A 312
 None
 1.17A 5odhG-4hu8A:
1.7		 5odhG-4hu8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 8 GLU A  24
VAL A 101
LEU A  27
THR A 106
 None
 1.00A 5syjB-4hu8A:
undetectable		 5syjB-4hu8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4hu8 GH10 XYLANASE
(Globitermes
brachycerastes) 		4 / 5 LEU A 148
TYR A 152
ILE A 295
GLY A 431
 None
 0.91A 6hd6A-4hu8A:
undetectable		 6hd6A-4hu8A:
10.79