SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4huc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 None
 1.39A 1gtnO-4hucA:
undetectable
1gtnP-4hucA:
undetectable		 1gtnO-4hucA:
14.94
1gtnP-4hucA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		5 / 9 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 None
 1.40A 1gtnQ-4hucA:
undetectable
1gtnR-4hucA:
undetectable		 1gtnQ-4hucA:
14.94
1gtnR-4hucA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		5 / 11 ASN A 356
MET A 280
GLY A 281
THR A 287
GLY A 332
 None
 1.07A 1jr1A-4hucA:
undetectable		 1jr1A-4hucA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 356
GLY A 281
THR A 287
GLY A 332
 None
 0.75A 1jr1B-4hucA:
undetectable		 1jr1B-4hucA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 264
LEU A 355
MET A 280
SER A 329
LEU A 385
 None
 1.18A 2po7B-4hucA:
undetectable		 2po7B-4hucA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 374
ASP A 389
LEU A 391
GLY A 392
ASN A 395
 None
 1.20A 4eb4D-4hucA:
undetectable		 4eb4D-4hucA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 356
GLY A 281
THR A 287
GLY A 332
 None
 0.68A 4fo4B-4hucA:
undetectable		 4fo4B-4hucA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 374
ASP A 389
LEU A 391
GLY A 392
 None
 0.81A 4iqqC-4hucA:
undetectable		 4iqqC-4hucA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 386
ASP A 389
SER A 331
SER A 329
 ACT  A 507 (-4.8A)
None
None
None
 1.24A 4k7gB-4hucA:
undetectable		 4k7gB-4hucA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 243
VAL A 156
ILE A 172
LEU A 233
 None
 0.94A 4l1wB-4hucA:
undetectable		 4l1wB-4hucA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 367
ALA A 362
THR A 326
TYR A 366
 None
 1.30A 4w5qA-4hucA:
undetectable		 4w5qA-4hucA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 367
ALA A 362
THR A 326
TYR A 366
 None
 1.32A 4z4fA-4hucA:
undetectable		 4z4fA-4hucA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 367
ALA A 362
THR A 326
TYR A 366
 None
 1.25A 4z4hA-4hucA:
undetectable		 4z4hA-4hucA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 367
ALA A 362
THR A 326
TYR A 366
 None
 1.24A 4z4iA-4hucA:
undetectable		 4z4iA-4hucA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 308
TYR A 298
GLN A 327
 None
 0.83A 5jsdA-4hucA:
2.2
5jsdB-4hucA:
2.7		 5jsdA-4hucA:
18.07
5jsdB-4hucA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 308
TYR A 298
GLN A 327
 None
 0.84A 5jsdB-4hucA:
2.7
5jsdC-4hucA:
2.6		 5jsdB-4hucA:
18.07
5jsdC-4hucA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		4 / 8 SER A 351
THR A 278
THR A 380
THR A 287
 None
 0.99A 5l4eA-4hucA:
undetectable
5l4eB-4hucA:
undetectable
5l4eC-4hucA:
undetectable
5l4eD-4hucA:
undetectable
5l4eE-4hucA:
undetectable		 5l4eA-4hucA:
21.43
5l4eB-4hucA:
21.43
5l4eC-4hucA:
21.43
5l4eD-4hucA:
21.43
5l4eE-4hucA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 374
ASP A 389
LEU A 391
GLY A 392
ASN A 395
 None
 1.04A 5x66A-4hucA:
undetectable
5x66B-4hucA:
undetectable		 5x66A-4hucA:
20.06
5x66B-4hucA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 374
ASP A 389
LEU A 391
GLY A 392
ASN A 395
 None
 1.05A 5x66C-4hucA:
undetectable		 5x66C-4hucA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 211
ARG A 209
ASP A 393
 None
 0.84A 6d8pA-4hucA:
undetectable		 6d8pA-4hucA:
15.41