SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hum'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4hum MULTIDRUG EFFLUX
PROTEIN
PROTEIN B
(Neisseria
gonorrhoeae;
Escherichia
coli) 		4 / 4 SER B  55
GLU B   9
SER A 460
ASP B  23
 None
 1.16A 1h1dA-4humB:
undetectable		 1h1dA-4humB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 109
ALA A 149
LEU A 114
PHE A 110
ILE A 106
 None
 1.14A 1rb2B-4humA:
undetectable		 1rb2B-4humA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4hum MULTIDRUG EFFLUX
PROTEIN
PROTEIN B
(Neisseria
gonorrhoeae;
Escherichia
coli) 		4 / 5 SER B  55
GLU B   9
SER A 460
ASP B  23
 None
 1.18A 1vidA-4humB:
undetectable		 1vidA-4humB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4hum PROTEIN B
(Escherichia
coli) 		3 / 3 SER B  55
GLU B   9
ASP B  23
 None
 0.70A 2zthA-4humB:
undetectable		 2zthA-4humB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4hum PROTEIN B
(Escherichia
coli) 		3 / 3 SER B  55
GLU B   9
ASP B  23
 None
 0.69A 3bwmA-4humB:
undetectable		 3bwmA-4humB:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4hum PROTEIN B
(Escherichia
coli) 		3 / 3 SER B  55
GLU B   9
ASP B  23
 None
 0.71A 3bwyA-4humB:
undetectable		 3bwyA-4humB:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 4hum PROTEIN B
(Escherichia
coli) 		4 / 6 ASP B  23
TRP B  22
ILE B  85
SER B   3
 None
 0.98A 3ckzA-4humB:
undetectable		 3ckzA-4humB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		4 / 8 GLY A  91
GLY A  94
GLY A  97
ILE A 101
 None
 0.46A 3d41A-4humA:
undetectable		 3d41A-4humA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 GLY A 309
GLY A 389
GLU A 316
ALA A  82
 None
 0.81A 3fpjB-4humA:
undetectable		 3fpjB-4humA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		4 / 4 PHE A 244
LYS A 245
ILE A 106
THR A  96
 None
 1.28A 3ia4B-4humA:
undetectable		 3ia4B-4humA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		4 / 8 ASN A 184
THR A 206
LEU A 145
ALA A 200
 None
 1.04A 3kp6A-4humA:
1.2		 3kp6A-4humA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 PHE A  63
GLN A 138
PHE A 210
 None
 0.76A 3rv5A-4humA:
undetectable		 3rv5A-4humA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 GLY A  72
GLY A 255
LEU A 256
PHE A  70
LEU A 156
 None
 1.19A 3vywB-4humA:
undetectable		 3vywB-4humA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 GLY A  72
GLY A 255
LEU A 256
PHE A  70
LEU A 156
 None
 1.22A 3vywD-4humA:
undetectable		 3vywD-4humA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 SER A 324
GLY A 304
THR A 305
ILE A 308
 None
 0.80A 4acaC-4humA:
undetectable		 4acaC-4humA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4hum PROTEIN B
(Escherichia
coli) 		4 / 4 ASN B  88
SER B  17
LEU B  18
THR B  39
 None
 1.45A 4an2A-4humB:
undetectable		 4an2A-4humB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 4hum PROTEIN B
(Escherichia
coli) 		4 / 7 GLU B  38
ASP B  67
ASN B  88
ILE B  70
 None
 1.08A 4ii8A-4humB:
undetectable		 4ii8A-4humB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 109
ALA A 149
LEU A 114
PHE A 110
ILE A 106
 None
 1.15A 4ptjA-4humA:
undetectable		 4ptjA-4humA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		5 / 11 GLY A  97
GLY A  94
ILE A  81
GLY A 104
PHE A 244
 None
 1.19A 4qoiA-4humA:
undetectable
4qoiB-4humA:
undetectable		 4qoiA-4humA:
20.72
4qoiB-4humA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 ALA A  87
GLY A  91
ALA A  93
GLU A  95
 None
 0.85A 4r1zB-4humA:
undetectable		 4r1zB-4humA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 ALA A  87
GLY A  91
ALA A  93
THR A  96
 None
 0.84A 4r1zB-4humA:
undetectable		 4r1zB-4humA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		6 / 12 LEU A  84
LEU A 163
ALA A  82
ALA A  76
ALA A 160
ILE A 250
 None
 1.16A 4x20B-4humA:
undetectable		 4x20B-4humA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4hum PROTEIN B
(Escherichia
coli) 		3 / 3 SER B  55
GLU B   9
ASP B  23
 None
 0.69A 4xudA-4humB:
undetectable		 4xudA-4humB:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ILE A  73
ARG A 388
ALA A 160
LEU A  77
PHE A  70
 None
 1.45A 4zo1X-4humA:
2.1		 4zo1X-4humA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 ALA A 205
THR A 206
VAL A 209
VAL A  43
 None
 0.83A 5eckA-4humA:
undetectable		 5eckA-4humA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 ALA A 205
THR A 206
VAL A 209
VAL A  43
 None
 0.86A 5eckD-4humA:
undetectable		 5eckD-4humA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 ALA A 205
THR A 206
VAL A 209
VAL A  43
 None
 0.72A 5eclA-4humA:
undetectable		 5eclA-4humA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 ALA A 205
THR A 206
VAL A 209
VAL A  43
 None
 0.80A 5eclD-4humA:
undetectable		 5eclD-4humA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4hum MULTIDRUG EFFLUX
PROTEIN
PROTEIN B
(Neisseria
gonorrhoeae;
Escherichia
coli) 		4 / 5 SER B  55
GLU B   9
SER A 460
ASP B  23
 None
 1.18A 5fhrA-4humB:
undetectable		 5fhrA-4humB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 183
GLY A 199
GLY A 198
ALA A 205
GLY A  49
 None
 1.07A 5kb5A-4humA:
undetectable		 5kb5A-4humA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 254
TRP A 211
ILE A 169
ALA A 158
LEU A 156
 None
 1.32A 5oy02-4humA:
undetectable		 5oy02-4humA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 ILE A 254
TRP A 211
ILE A 169
ALA A 158
LEU A 156
 None
 1.38A 5zjiB-4humA:
2.0		 5zjiB-4humA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4hum MULTIDRUG EFFLUX
PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 ARG A 314
GLU A 316
PHE A 310
ARG A 307
ILE A 308
 None
 1.06A 6bniB-4humA:
undetectable		 6bniB-4humA:
13.08