SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4huz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQP_A_FCNA4002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 10 HIS A 227
TYR A 266
GLU A 276
HIS A  11
THR A  13
 FE  A 401 ( 3.0A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
FE  A 401 ( 3.2A)
SO4  A 402 ( 2.8A)
 0.41A 1lqpA-4huzA:
8.5
1lqpB-4huzA:
8.5		 1lqpA-4huzA:
17.15
1lqpB-4huzA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQP_B_FCNB4001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 10 HIS A  11
THR A  13
HIS A 227
TYR A 266
GLU A 276
 FE  A 401 ( 3.2A)
SO4  A 402 ( 2.8A)
FE  A 401 ( 3.0A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
 0.41A 1lqpA-4huzA:
8.5
1lqpB-4huzA:
8.5		 1lqpA-4huzA:
17.15
1lqpB-4huzA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NKI_A_PPFA5001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 9 HIS A 227
TYR A 266
GLU A 276
HIS A  11
THR A  13
 FE  A 401 ( 3.0A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
FE  A 401 ( 3.2A)
SO4  A 402 ( 2.8A)
 0.40A 1nkiA-4huzA:
8.7
1nkiB-4huzA:
8.6		 1nkiA-4huzA:
17.15
1nkiB-4huzA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NKI_B_PPFB5002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 9 HIS A  11
THR A  13
HIS A 227
TYR A 266
GLU A 276
 FE  A 401 ( 3.2A)
SO4  A 402 ( 2.8A)
FE  A 401 ( 3.0A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
 0.40A 1nkiA-4huzA:
8.7
1nkiB-4huzA:
8.6		 1nkiA-4huzA:
17.15
1nkiB-4huzA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		3 / 3 PRO A  46
LEU A  39
ARG A  37
 None
 0.79A 3aqiB-4huzA:
undetectable		 3aqiB-4huzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 12 SER A 264
HIS A 227
PHE A  82
LEU A   9
HIS A  10
 SO4  A 402 ( 3.8A)
FE  A 401 ( 3.0A)
None
None
None
 1.36A 3lxeA-4huzA:
undetectable		 3lxeA-4huzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 12 SER A 264
HIS A 227
PHE A  82
LEU A   9
HIS A  10
 SO4  A 402 ( 3.8A)
FE  A 401 ( 3.0A)
None
None
None
 1.35A 3lxeB-4huzA:
undetectable		 3lxeB-4huzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 11 HIS A  11
HIS A 227
ARG A 259
TYR A 266
GLU A 276
 FE  A 401 ( 3.2A)
FE  A 401 ( 3.0A)
SO4  A 402 (-3.7A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
 1.46A 4ir0A-4huzA:
7.6
4ir0B-4huzA:
8.4		 4ir0A-4huzA:
20.00
4ir0B-4huzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 12 HIS A 227
ARG A 259
TYR A 266
HIS A  11
TYR A  51
 FE  A 401 ( 3.0A)
SO4  A 402 (-3.7A)
SO4  A 402 (-4.9A)
FE  A 401 ( 3.2A)
None
 1.48A 4jd1A-4huzA:
8.1
4jd1B-4huzA:
8.3		 4jd1A-4huzA:
20.00
4jd1B-4huzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 12 HIS A 227
TYR A 266
GLU A 276
HIS A  11
TYR A  51
 FE  A 401 ( 3.0A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
FE  A 401 ( 3.2A)
None
 0.27A 4jd1A-4huzA:
8.1
4jd1B-4huzA:
8.3		 4jd1A-4huzA:
20.00
4jd1B-4huzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 12 HIS A  11
TYR A  51
HIS A 227
TYR A 266
GLU A 276
 FE  A 401 ( 3.2A)
None
FE  A 401 ( 3.0A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
 0.44A 4jd1A-4huzA:
8.1
4jd1B-4huzA:
8.3		 4jd1A-4huzA:
20.00
4jd1B-4huzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		6 / 12 HIS A 227
ARG A 259
TYR A 266
GLU A 276
HIS A  11
TYR A  51
 FE  A 401 ( 3.0A)
SO4  A 402 (-3.7A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
FE  A 401 ( 3.2A)
None
 1.38A 4jh3A-4huzA:
8.3
4jh3B-4huzA:
7.9		 4jh3A-4huzA:
19.62
4jh3B-4huzA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 11 HIS A  11
HIS A 227
ARG A 259
TYR A 266
GLU A 276
 FE  A 401 ( 3.2A)
FE  A 401 ( 3.0A)
SO4  A 402 (-3.7A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
 1.46A 4jh3A-4huzA:
8.3
4jh3B-4huzA:
7.9		 4jh3A-4huzA:
19.62
4jh3B-4huzA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 10 HIS A 227
ARG A 259
TYR A 266
GLU A 276
HIS A  11
 FE  A 401 ( 3.0A)
SO4  A 402 (-3.7A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
FE  A 401 ( 3.2A)
 1.46A 4jh6A-4huzA:
7.9
4jh6B-4huzA:
7.9		 4jh6A-4huzA:
19.62
4jh6B-4huzA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 10 HIS A  11
HIS A 227
ARG A 259
TYR A 266
GLU A 276
 FE  A 401 ( 3.2A)
FE  A 401 ( 3.0A)
SO4  A 402 (-3.7A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
 1.48A 4jh6A-4huzA:
7.9
4jh6B-4huzA:
7.9		 4jh6A-4huzA:
19.62
4jh6B-4huzA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 10 HIS A  11
HIS A 227
ARG A 259
TYR A 266
GLU A 276
 FE  A 401 ( 3.2A)
FE  A 401 ( 3.0A)
SO4  A 402 (-3.7A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
 1.46A 4jh8A-4huzA:
7.8
4jh8B-4huzA:
7.7		 4jh8A-4huzA:
19.62
4jh8B-4huzA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		4 / 8 PHE A  52
GLY A  17
THR A  18
THR A  65
 None
 1.01A 4k87A-4huzA:
undetectable		 4k87A-4huzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		6 / 10 ILE A 318
ALA A  19
THR A  71
ILE A  47
LEU A  50
LEU A  39
 None
 1.26A 4rz7A-4huzA:
undetectable		 4rz7A-4huzA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		3 / 3 VAL A 133
HIS A 100
VAL A  29
 None
 0.71A 5jmnC-4huzA:
undetectable		 5jmnC-4huzA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 12 LEU A 296
LYS A 297
GLY A 293
LEU A  50
ALA A  19
 None
 1.17A 5kbwA-4huzA:
undetectable		 5kbwA-4huzA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		4 / 7 GLN A  20
ASP A  24
HIS A 104
TYR A 144
 None
 1.43A 5ov9B-4huzA:
undetectable		 5ov9B-4huzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3D_A_FCNA205_1
(FOSFOMYCIN
RESISTANCE PROTEIN)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		5 / 10 HIS A  11
THR A  13
HIS A 227
TYR A 266
GLU A 276
 FE  A 401 ( 3.2A)
SO4  A 402 ( 2.8A)
FE  A 401 ( 3.0A)
SO4  A 402 (-4.9A)
FE  A 401 ( 2.6A)
 0.42A 5v3dA-4huzA:
8.6
5v3dB-4huzA:
8.6		 5v3dA-4huzA:
20.20
5v3dB-4huzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE
(Sphingobium
chlorophenolicum) 		6 / 12 VAL A 273
GLU A 132
PHE A 275
PHE A  82
PHE A 115
ILE A 184
 None
 1.38A 6becA-4huzA:
undetectable
6becB-4huzA:
undetectable
6becC-4huzA:
undetectable		 6becA-4huzA:
19.73
6becB-4huzA:
19.73
6becC-4huzA:
19.73