SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 10 LEU A 348
VAL A 376
ILE A 453
VAL A 462
ILE A 460
 None
 0.99A 1hsgA-4hv4A:
undetectable		 1hsgA-4hv4A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 11 LEU A  51
ASP A  50
ILE A  27
GLY A  26
HIS A  23
 None
 1.24A 1s9aA-4hv4A:
undetectable		 1s9aA-4hv4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		3 / 3 LEU A 146
HIS A 120
ILE A 122
 None
 0.54A 1s9pB-4hv4A:
undetectable		 1s9pB-4hv4A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		6 / 10 LEU A 112
ILE A  27
GLY A  28
GLY A  29
VAL A 151
ILE A  35
 None
 1.25A 1sdtA-4hv4A:
undetectable		 1sdtA-4hv4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 11 LEU A 112
ILE A  27
GLY A  28
GLY A  29
ILE A  35
 None
 0.97A 1sduA-4hv4A:
undetectable		 1sduA-4hv4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 6 ALA A 297
TYR A 263
ILE A 260
LEU A 286
 None
 0.95A 1xvaA-4hv4A:
2.2
1xvaB-4hv4A:
undetectable		 1xvaA-4hv4A:
18.98
1xvaB-4hv4A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 GLY A  33
GLY A  28
THR A 161
ALA A 163
ALA A  36
 None
 0.98A 2gluB-4hv4A:
4.3		 2gluB-4hv4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 TYR A 141
PRO A 187
ALA A 300
ALA A 302
THR A 248
 None
 1.24A 2x2nA-4hv4A:
undetectable		 2x2nA-4hv4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 TYR A 141
PRO A 187
ALA A 300
ALA A 302
THR A 248
 None
 1.21A 2x2nB-4hv4A:
undetectable		 2x2nB-4hv4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 TYR A 141
PRO A 187
ALA A 300
ALA A 302
THR A 248
 None
 1.23A 2x2nC-4hv4A:
undetectable		 2x2nC-4hv4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 6 ASP A 201
LEU A 210
LEU A 390
HIS A 355
 None
 0.94A 3bj8C-4hv4A:
undetectable
3bj8D-4hv4A:
undetectable		 3bj8C-4hv4A:
16.50
3bj8D-4hv4A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 7 ILE A 314
GLY A 308
VAL A 258
LEU A 137
 None
 0.73A 3elzA-4hv4A:
undetectable		 3elzA-4hv4A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 10 LEU A 348
VAL A 376
ILE A 453
VAL A 462
ILE A 460
 None
 0.90A 3em3B-4hv4A:
undetectable		 3em3B-4hv4A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 LEU A 348
VAL A 376
ILE A 453
VAL A 462
ILE A 460
 None
 0.96A 3em6B-4hv4A:
undetectable		 3em6B-4hv4A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 LEU A 348
VAL A 376
ILE A 453
VAL A 462
ILE A 460
 None
 1.06A 3k4vC-4hv4A:
undetectable		 3k4vC-4hv4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 LEU A 348
VAL A 376
ILE A 453
VAL A 462
ILE A 460
 None
 0.97A 3mwsB-4hv4A:
undetectable		 3mwsB-4hv4A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 11 VAL A  83
ILE A  27
GLY A  33
ALA A  36
LEU A  39
 None
 1.16A 3n8yA-4hv4A:
undetectable		 3n8yA-4hv4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 11 VAL A 151
PHE A 321
GLY A 129
ASN A 293
GLU A 174
 None
None
AMP  A 501 (-3.2A)
None
None
 1.30A 3owxA-4hv4A:
4.0
3owxB-4hv4A:
4.2		 3owxA-4hv4A:
19.10
3owxB-4hv4A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		3 / 3 HIS A  70
ARG A  72
GLU A  94
 None
 0.97A 3qf1A-4hv4A:
undetectable		 3qf1A-4hv4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 10 ILE A  46
VAL A  38
PHE A  24
ILE A 106
ILE A  22
 None
 1.32A 3um5A-4hv4A:
3.3		 3um5A-4hv4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 10 ILE A  46
VAL A  38
PHE A  24
ILE A 106
ILE A  22
 None
 1.31A 3um5B-4hv4A:
2.9		 3um5B-4hv4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 HIS A  70
GLY A  48
ASN A  75
ALA A  36
LEU A  60
 None
 1.20A 3vywB-4hv4A:
3.2		 3vywB-4hv4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 HIS A  70
GLY A  48
ASN A  75
ALA A  36
LEU A  60
 None
 1.22A 3vywD-4hv4A:
2.6		 3vywD-4hv4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 6 ILE A 247
VAL A 236
ILE A 231
CYH A 230
 None
 0.92A 4asdA-4hv4A:
undetectable		 4asdA-4hv4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 LEU A 348
VAL A 376
ILE A 453
VAL A 462
ILE A 460
 None
 0.89A 4dqbA-4hv4A:
undetectable		 4dqbA-4hv4A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 11 ILE A 309
ALA A 304
GLU A 306
GLY A 121
TYR A 170
 None
 1.18A 4e47A-4hv4A:
undetectable		 4e47A-4hv4A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 11 ILE A 309
ALA A 304
GLU A 306
GLY A 121
TYR A 170
 None
 1.20A 4e47C-4hv4A:
undetectable		 4e47C-4hv4A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 11 ILE A 140
ALA A 302
LEU A 274
LEU A 286
THR A 305
 None
 1.16A 4i1nA-4hv4A:
3.5		 4i1nA-4hv4A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 11 ILE A 309
ALA A 304
GLU A 306
GLY A 121
TYR A 170
 None
 1.19A 4jdsC-4hv4A:
undetectable		 4jdsC-4hv4A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 ILE A 309
ALA A 304
GLU A 306
GLY A 121
TYR A 170
 None
 1.22A 4jlgA-4hv4A:
undetectable		 4jlgA-4hv4A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 11 ILE A 309
ALA A 304
GLU A 306
GLY A 121
TYR A 170
 None
 1.24A 4jlgB-4hv4A:
undetectable		 4jlgB-4hv4A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 6 MET A 406
ILE A 429
ARG A 432
VAL A 359
 None
 1.41A 4mk4B-4hv4A:
2.8		 4mk4B-4hv4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 11 VAL A 151
PHE A 321
GLY A 129
ASN A 293
GLU A 174
 None
None
AMP  A 501 (-3.2A)
None
None
 1.29A 4zvmA-4hv4A:
3.3
4zvmB-4hv4A:
3.7		 4zvmA-4hv4A:
19.18
4zvmB-4hv4A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 11 ILE A 309
ALA A 304
GLU A 306
GLY A 121
TYR A 170
 None
 1.14A 5ayfA-4hv4A:
undetectable		 5ayfA-4hv4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 8 PHE A 217
GLU A 177
HIS A 128
THR A 249
 None
None
AMP  A 501 (-4.6A)
None
 1.04A 5hqaA-4hv4A:
2.7		 5hqaA-4hv4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 LEU A 348
VAL A 376
ILE A 453
VAL A 462
ILE A 460
 None
 1.02A 5kqyA-4hv4A:
undetectable		 5kqyA-4hv4A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 4 SER A 138
ALA A 135
GLN A 322
THR A 324
 None
 1.20A 5n0rA-4hv4A:
2.1		 5n0rA-4hv4A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 4 SER A 138
ALA A 135
GLN A 322
THR A 324
 None
 1.19A 5n0sA-4hv4A:
2.2		 5n0sA-4hv4A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 5 SER A 138
ALA A 135
GLN A 322
THR A 324
 None
 1.21A 5n0tA-4hv4A:
3.8		 5n0tA-4hv4A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 4 SER A 138
ALA A 135
GLN A 322
THR A 324
 None
 1.21A 5n0wA-4hv4A:
2.2		 5n0wA-4hv4A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 5 SER A 138
ALA A 135
GLN A 322
THR A 324
 None
 1.24A 5n0wB-4hv4A:
3.8		 5n0wB-4hv4A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 4 SER A 138
ALA A 135
GLN A 322
THR A 324
 None
 1.20A 5n0xA-4hv4A:
2.7		 5n0xA-4hv4A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 5 SER A 138
ALA A 135
GLN A 322
THR A 324
 None
 1.19A 5n4iA-4hv4A:
3.2		 5n4iA-4hv4A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		4 / 6 ASN A 396
ALA A 395
PRO A 356
VAL A 397
 None
 1.23A 5umd2-4hv4A:
undetectable
5umdF-4hv4A:
undetectable		 5umd2-4hv4A:
9.56
5umdF-4hv4A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 10 GLY A 464
GLY A 353
ILE A 468
ALA A 465
GLY A 469
 None
AMP  A 501 (-3.5A)
None
None
None
 1.07A 6e5zA-4hv4A:
2.5		 6e5zA-4hv4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Yersinia
pestis) 		5 / 12 LEU A 405
ILE A 429
ILE A 453
ASP A 436
ILE A 438
 None
 1.06A 6emuC-4hv4A:
4.2		 6emuC-4hv4A:
17.28