SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4hva CASPASE-6
(Homo
sapiens) 		5 / 10 ASN A  73
ALA A  69
LEU A 119
VAL A 117
ILE A 229
 None
 1.28A 1claA-4hvaA:
undetectable		 1claA-4hvaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4hva CASPASE-6
(Homo
sapiens) 		5 / 12 ILE A 159
LEU A 286
PHE A 288
LEU A  81
LEU A 236
 None
 1.19A 1dtlA-4hvaA:
undetectable		 1dtlA-4hvaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4hva CASPASE-6
(Homo
sapiens) 		5 / 12 CYH A 113
ALA A 111
VAL A 106
LEU A  48
PHE A  83
 None
 1.27A 1s9pB-4hvaA:
undetectable		 1s9pB-4hvaA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4hva CASPASE-6
(Homo
sapiens) 		5 / 12 PHE A 288
LYS A 285
ILE A 157
PHE A 245
GLY A  45
 None
 1.25A 2lbdA-4hvaA:
undetectable		 2lbdA-4hvaA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4hva CASPASE-6
(Homo
sapiens) 		4 / 5 PHE A 288
PHE A 114
SER A 150
PHE A  78
 None
 1.34A 2v0mD-4hvaA:
undetectable		 2v0mD-4hvaA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4hva CASPASE-6
(Homo
sapiens) 		4 / 8 LEU A 232
VAL A 115
ILE A  49
PHE A  78
 None
 0.95A 2weyB-4hvaA:
undetectable		 2weyB-4hvaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4hva CASPASE-6
(Homo
sapiens) 		4 / 5 ILE A 157
MET A  39
LEU A 282
LEU A 286
 None
 1.16A 2zb7A-4hvaA:
3.8		 2zb7A-4hvaA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 4hva CASPASE-6
(Homo
sapiens) 		4 / 7 GLY A 153
MET A 208
CYH A 209
PHE A 278
 None
 1.12A 3ko0K-4hvaA:
undetectable
3ko0S-4hvaA:
undetectable		 3ko0K-4hvaA:
16.34
3ko0S-4hvaA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4hva CASPASE-6
(Homo
sapiens) 		5 / 12 ASP A 112
ASP A  40
HIS A  41
ASP A 205
LEU A 200
 None
 1.33A 3lmyA-4hvaA:
undetectable		 3lmyA-4hvaA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4hva CASPASE-6
(Homo
sapiens) 		5 / 12 ILE A 127
ALA A 162
GLN A 161
LEU A 119
ILE A 100
 None
 1.19A 3uvvB-4hvaA:
undetectable		 3uvvB-4hvaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4hva CASPASE-6
(Homo
sapiens) 		4 / 4 GLY A 215
VAL A 212
PHE A 118
ILE A 160
 None
 1.08A 4xv2B-4hvaA:
undetectable		 4xv2B-4hvaA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4hva CASPASE-6
(Homo
sapiens) 		4 / 8 PHE A  55
ARG A  65
THR A 222
GLY A  66
 None
 0.89A 5nzxA-4hvaA:
undetectable		 5nzxA-4hvaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4hva CASPASE-6
(Homo
sapiens) 		4 / 5 CYH A 264
ILE A 270
HIS A 168
HIS A 219
 4HV  A 401 ( 3.1A)
None
4HV  A 401 (-4.5A)
4HV  A 401 ( 4.2A)
 1.47A 5ocsA-4hvaA:
undetectable		 5ocsA-4hvaA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4hva CASPASE-6
(Homo
sapiens) 		4 / 5 CYH A 264
ILE A 270
HIS A 168
HIS A 219
 4HV  A 401 ( 3.1A)
None
4HV  A 401 (-4.5A)
4HV  A 401 ( 4.2A)
 1.47A 5ocsC-4hvaA:
undetectable		 5ocsC-4hvaA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4hva CASPASE-6
(Homo
sapiens) 		4 / 6 LEU A  74
VAL A 103
PHE A 118
PHE A 143
 None
 1.04A 6h7lA-4hvaA:
undetectable		 6h7lA-4hvaA:
22.07