SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HSH_A_MK1A401_1 (HIV-II PROTEASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	GLY A 195 ALA A 196 GLY A 106 ILE A 188 ILE A 199	None	0.79A	1hshA-4hvlA: undetectable	1hshA-4hvlA: 13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_B_115B1_2 (HMG-COA REDUCTASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	4 / 8	ARG A 154 SER A 157 ASN A 115 ASP A 111	None	1.01A	1hwiB-4hvlA: undetectable	1hwiB-4hvlA: 23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_B_115B1_2 (HMG-COA REDUCTASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	4 / 8	ARG A 154 SER A 157 SER A 118 ASP A 111	None	1.27A	1hwiB-4hvlA: undetectable	1hwiB-4hvlA: 23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_A_117A2_1 (HMG-COA REDUCTASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	4 / 8	ARG A 154 SER A 157 ASN A 115 ASP A 111	None	0.92A	1hwkA-4hvlA: undetectable	1hwkA-4hvlA: 23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_C_117C4_1 (HMG-COA REDUCTASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	4 / 8	ARG A 154 SER A 157 ASN A 115 ASP A 111	None	0.88A	1hwkC-4hvlA: undetectable	1hwkC-4hvlA: 23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_C_117C4_1 (HMG-COA REDUCTASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	4 / 8	ARG A 154 SER A 157 SER A 118 ASP A 111	None	1.24A	1hwkC-4hvlA: undetectable	1hwkC-4hvlA: 23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_D_117D3_2 (HMG-COA REDUCTASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	4 / 8	ARG A 154 SER A 157 ASN A 115 ASP A 111	None	0.90A	1hwkD-4hvlA: undetectable	1hwkD-4hvlA: 23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_D_117D3_2 (HMG-COA REDUCTASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	4 / 8	ARG A 154 SER A 157 SER A 118 ASP A 111	None	1.24A	1hwkD-4hvlA: undetectable	1hwkD-4hvlA: 23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SG9_C_SAMC303_0 (HEMK PROTEIN)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	PRO A 35 GLY A 219 ALA A 185 VAL A 28 GLU A 25	None None None None ZN A 507 (-2.1A)	1.03A	1sg9C-4hvlA: undetectable	1sg9C-4hvlA: 20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_B_GBNB914_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 10	TYR A 339 GLY A 284 GLY A 282 ALA A 303 ALA A 302	None	1.18A	2ej3B-4hvlA: undetectable	2ej3B-4hvlA: 24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2H42_B_VIAB902_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	ALA A 357 ILE A 360 VAL A 226 ALA A 225 ILE A 199	IMD A 510 (-3.5A) None IMD A 510 (-4.8A) None None	0.91A	2h42B-4hvlA: undetectable	2h42B-4hvlA: 20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q64_B_1UNB1001_2 (PROTEASE RETROPEPSIN)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	3 / 3	ARG A 73 THR A 390 VAL A 386	None	0.97A	2q64A-4hvlA: undetectable	2q64A-4hvlA: 15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X9G_A_LYAA1270_2 (PTERIDINE REDUCTASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	3 / 3	MET A 294 VAL A 382 GLU A 306	None	0.84A	2x9gA-4hvlA: 3.7	2x9gA-4hvlA: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DOU_A_SAMA1_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	GLY A 381 GLY A 371 GLY A 372 ILE A 383 ALA A 301	None	0.90A	3douA-4hvlA: undetectable	3douA-4hvlA: 17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KEE_A_30BA500_1 (GENOME POLYPROTEIN)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	HIS A 123 ASP A 92 GLY A 332 SER A 334 ALA A 204	ZN A 506 ( 3.3A) None ACT A 512 (-3.5A) ZN A 506 ( 2.2A) ACT A 512 ( 4.7A)	0.99A	3keeA-4hvlA: undetectable	3keeA-4hvlA: 19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LS4_H_TCIH220_1 (HEAVY CHAIN OF ANTIBODY FAB FRAGMENT)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 10	VAL A 280 LEU A 278 TYR A 339 VAL A 382 GLY A 379	None	1.13A	3ls4H-4hvlA: undetectable	3ls4H-4hvlA: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S45_B_478B201_2 (PROTEASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 11	GLY A 195 ALA A 196 GLY A 106 ILE A 188 ILE A 199	None	0.85A	3s45B-4hvlA: undetectable	3s45B-4hvlA: 13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUE_B_SUEB1201_1 (NS3 PROTEASE, NS4A PROTEIN)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	HIS A 123 ASP A 92 GLY A 332 SER A 334 ALA A 204	ZN A 506 ( 3.3A) None ACT A 512 (-3.5A) ZN A 506 ( 2.2A) ACT A 512 ( 4.7A)	1.02A	3sueB-4hvlA: undetectable	3sueB-4hvlA: 19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUF_A_SUEA1201_1 (NS3 PROTEASE, NS4A PROTEIN)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	HIS A 123 ASP A 92 GLY A 332 SER A 334 ALA A 204	ZN A 506 ( 3.3A) None ACT A 512 (-3.5A) ZN A 506 ( 2.2A) ACT A 512 ( 4.7A)	0.94A	3sufA-4hvlA: undetectable	3sufA-4hvlA: 21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUF_C_SUEC1201_1 (NS3 PROTEASE, NS4A PROTEIN)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 11	HIS A 123 ASP A 92 GLY A 332 SER A 334 ALA A 204	ZN A 506 ( 3.3A) None ACT A 512 (-3.5A) ZN A 506 ( 2.2A) ACT A 512 ( 4.7A)	1.07A	3sufC-4hvlA: undetectable	3sufC-4hvlA: 21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_A_CHDA1504_0 (FERROCHELATASE, MITOCHONDRIAL)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	4 / 4	PRO A 352 LEU A 354 ILE A 347 ARG A 362	None	1.45A	3w1wA-4hvlA: undetectable	3w1wA-4hvlA: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM8_A_RFXA603_1 (TRANSPORTER)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	VAL A 90 ALA A 89 GLY A 133 ASP A 92 THR A 127	None	1.17A	4mm8A-4hvlA: undetectable	4mm8A-4hvlA: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKV_C_AERC601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	4 / 6	LEU A 153 GLU A 203 VAL A 218 ALA A 221	None ZN A 501 ( 3.0A) None None	1.14A	4nkvC-4hvlA: undetectable	4nkvC-4hvlA: 18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q5M_A_ROCA1101_1 (PROTEASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	GLY A 195 ILE A 188 THR A 39 VAL A 233 ILE A 201	None None IMD A 509 ( 3.8A) None None	0.96A	4q5mA-4hvlA: undetectable	4q5mA-4hvlA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW0_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	4 / 7	THR A 390 ALA A 388 THR A 366 ALA A 367	None	1.03A	4qw0K-4hvlA: undetectable	4qw0K-4hvlA: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW0_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	4 / 7	THR A 390 ALA A 388 THR A 366 ALA A 367	None	1.03A	4qw0Y-4hvlA: undetectable	4qw0Y-4hvlA: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V1F_A_BQ1A1087_0 (F0F1 ATP SYNTHASE SUBUNIT C)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	3 / 3	GLU A 76 ALA A 77 PHE A 80	None	0.60A	4v1fA-4hvlA: undetectable	4v1fA-4hvlA: 13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V1F_C_BQ1C1087_0 (F0F1 ATP SYNTHASE SUBUNIT C)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	3 / 3	GLU A 76 ALA A 77 PHE A 80	None	0.64A	4v1fC-4hvlA: undetectable	4v1fC-4hvlA: 13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E5J_A_017A201_1 (PROTEASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	GLY A 195 ALA A 196 GLY A 106 ILE A 188 ILE A 199	None	0.81A	5e5jA-4hvlA: undetectable	5e5jA-4hvlA: 13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E5K_B_017B201_2 (HIV-1 PROTEASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	GLY A 195 ALA A 196 GLY A 106 ILE A 188 ILE A 199	None	0.81A	5e5kB-4hvlA: undetectable	5e5kB-4hvlA: 13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G44_A_YTZA1512_1 (NUCLEAR RECEPTOR ROR-GAMMA)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 9	LEU A 194 LEU A 151 ALA A 225 VAL A 233 ALA A 89	IMD A 508 ( 4.4A) None None None None	1.40A	5g44A-4hvlA: undetectable	5g44A-4hvlA: 16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGJ_A_CTYA402_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	4 / 5	PRO A 289 LEU A 278 TYR A 339 PHE A 335	None	1.39A	5igjA-4hvlA: undetectable	5igjA-4hvlA: 24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JWA_A_ACTA609_0 (NADH DEHYDROGENASE, PUTATIVE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	3 / 3	VAL A 299 SER A 295 TRP A 298	None	1.02A	5jwaA-4hvlA: undetectable	5jwaA-4hvlA: 19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF3_K_BO2K305_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-1)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 11	ALA A 367 ALA A 365 GLY A 379 GLY A 300 ALA A 301	None	0.88A	5lf3K-4hvlA: undetectable 5lf3L-4hvlA: undetectable	5lf3K-4hvlA: 21.59 5lf3L-4hvlA: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF3_Y_BO2Y305_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-1)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 11	ALA A 367 ALA A 365 GLY A 379 GLY A 300 ALA A 301	None	0.89A	5lf3Y-4hvlA: undetectable 5lf3Z-4hvlA: undetectable	5lf3Y-4hvlA: 21.59 5lf3Z-4hvlA: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_K_6V8K305_0 (PROTEASOME SUBUNIT BETA TYPE-1 PROTEASOME SUBUNIT BETA TYPE-5)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 11	ALA A 367 ALA A 365 GLY A 379 GLY A 300 ALA A 301	None	0.90A	5lf7K-4hvlA: undetectable 5lf7L-4hvlA: undetectable	5lf7K-4hvlA: 21.59 5lf7L-4hvlA: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_Y_6V8Y306_0 (PROTEASOME SUBUNIT BETA TYPE-1 PROTEASOME SUBUNIT BETA TYPE-5)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 11	ALA A 367 ALA A 365 GLY A 379 GLY A 300 ALA A 301	None	0.90A	5lf7Y-4hvlA: undetectable 5lf7Z-4hvlA: undetectable	5lf7Y-4hvlA: 21.59 5lf7Z-4hvlA: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MM4_B_TA1B501_1 (TUBULIN BETA CHAIN)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 10	VAL A 90 LEU A 321 ALA A 338 SER A 341 THR A 309	None	1.17A	5mm4B-4hvlA: undetectable	5mm4B-4hvlA: 12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T2Z_B_017B201_2 (PROTEASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	GLY A 133 ALA A 132 VAL A 88 SER A 152 ILE A 150	None	0.74A	5t2zB-4hvlA: undetectable	5t2zB-4hvlA: 15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DH3_A_017A101_0 (PROTEASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 12	GLY A 195 ALA A 196 GLY A 106 ILE A 188 ILE A 199	None	0.91A	6dh3A-4hvlA: undetectable	6dh3A-4hvlA: 16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_K_BO2K301_0 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 11	ALA A 367 ALA A 365 GLY A 379 GLY A 300 ALA A 301	None	0.87A	6hwdK-4hvlA: undetectable 6hwdL-4hvlA: undetectable	6hwdK-4hvlA: 12.78 6hwdL-4hvlA: 12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_Y_BO2Y301_0 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 11	ALA A 367 ALA A 365 GLY A 379 GLY A 300 ALA A 301	None	0.87A	6hwdY-4hvlA: undetectable 6hwdZ-4hvlA: undetectable	6hwdY-4hvlA: 12.78 6hwdZ-4hvlA: 12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6IEY_A_CLMA401_0 (ESTERASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	5 / 11	ILE A 234 ALA A 271 GLY A 238 SER A 293 ALA A 336	None None ACT A 512 ( 4.3A) None None	1.29A	6ieyA-4hvlA: 4.0 6ieyB-4hvlA: 3.9	6ieyA-4hvlA: 22.86 6ieyB-4hvlA: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6JNH_A_ASCA202_0 (PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	3 / 3	ASN A 230 PRO A 356 GLN A 358	None	0.90A	6jnhA-4hvlA: undetectable	6jnhA-4hvlA: 17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6JOG_A_ASCA202_0 (PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE)	4hvl	MEMBRANE-ANCHORED MYCOSIN MYCP1 (Mycolicibacteriu m thermoresistibil e)	3 / 3	ASN A 230 PRO A 356 GLN A 358	None	0.92A	6jogA-4hvlA: undetectable	6jogA-4hvlA: 17.46

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HSH_A_MK1A401_1","HIV-II PROTEASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"GLY A 195;ALA A 196;GLY A 106;ILE A 188;ILE A 199","None","0.79A","1hshA-4hvlA:undetectable","1hshA-4hvlA:13.83"],["1HWI_B_115B1_2","HMG-COA REDUCTASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",4,"ARG A 154;SER A 157;ASN A 115;ASP A 111","None","1.01A","1hwiB-4hvlA:undetectable","1hwiB-4hvlA:23.36"],["1HWI_B_115B1_2","HMG-COA REDUCTASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",4,"ARG A 154;SER A 157;SER A 118;ASP A 111","None","1.27A","1hwiB-4hvlA:undetectable","1hwiB-4hvlA:23.36"],["1HWK_A_117A2_1","HMG-COA REDUCTASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",4,"ARG A 154;SER A 157;ASN A 115;ASP A 111","None","0.92A","1hwkA-4hvlA:undetectable","1hwkA-4hvlA:23.36"],["1HWK_C_117C4_1","HMG-COA REDUCTASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",4,"ARG A 154;SER A 157;ASN A 115;ASP A 111","None","0.88A","1hwkC-4hvlA:undetectable","1hwkC-4hvlA:23.36"],["1HWK_C_117C4_1","HMG-COA REDUCTASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",4,"ARG A 154;SER A 157;SER A 118;ASP A 111","None","1.24A","1hwkC-4hvlA:undetectable","1hwkC-4hvlA:23.36"],["1HWK_D_117D3_2","HMG-COA REDUCTASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",4,"ARG A 154;SER A 157;ASN A 115;ASP A 111","None","0.90A","1hwkD-4hvlA:undetectable","1hwkD-4hvlA:23.36"],["1HWK_D_117D3_2","HMG-COA REDUCTASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",4,"ARG A 154;SER A 157;SER A 118;ASP A 111","None","1.24A","1hwkD-4hvlA:undetectable","1hwkD-4hvlA:23.36"],["1SG9_C_SAMC303_0","HEMK PROTEIN","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"PRO A  35;GLY A 219;ALA A 185;VAL A  28;GLU A  25","None;None;None;None; ZN A 507 (-2.1A)","1.03A","1sg9C-4hvlA:undetectable","1sg9C-4hvlA:20.57"],["2EJ3_B_GBNB914_1","BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"TYR A 339;GLY A 284;GLY A 282;ALA A 303;ALA A 302","None","1.18A","2ej3B-4hvlA:undetectable","2ej3B-4hvlA:24.63"],["2H42_B_VIAB902_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"ALA A 357;ILE A 360;VAL A 226;ALA A 225;ILE A 199","IMD A 510 (-3.5A);None;IMD A 510 (-4.8A);None;None","0.91A","2h42B-4hvlA:undetectable","2h42B-4hvlA:20.52"],["2Q64_B_1UNB1001_2","PROTEASE RETROPEPSIN;PROTEASE RETROPEPSIN","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",3,"ARG A  73;THR A 390;VAL A 386","None","0.97A","2q64A-4hvlA:undetectable","2q64A-4hvlA:15.05"],["2X9G_A_LYAA1270_2","PTERIDINE REDUCTASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",3,"MET A 294;VAL A 382;GLU A 306","None","0.84A","2x9gA-4hvlA:3.7","2x9gA-4hvlA:22.31"],["3DOU_A_SAMA1_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"GLY A 381;GLY A 371;GLY A 372;ILE A 383;ALA A 301","None","0.90A","3douA-4hvlA:undetectable","3douA-4hvlA:17.68"],["3KEE_A_30BA500_1","GENOME POLYPROTEIN","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"HIS A 123;ASP A  92;GLY A 332;SER A 334;ALA A 204"," ZN A 506 ( 3.3A);None;ACT A 512 (-3.5A); ZN A 506 ( 2.2A);ACT A 512 ( 4.7A)","0.99A","3keeA-4hvlA:undetectable","3keeA-4hvlA:19.38"],["3LS4_H_TCIH220_1","HEAVY CHAIN OF ANTIBODY FAB FRAGMENT","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"VAL A 280;LEU A 278;TYR A 339;VAL A 382;GLY A 379","None","1.13A","3ls4H-4hvlA:undetectable","3ls4H-4hvlA:20.32"],["3S45_B_478B201_2","PROTEASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"GLY A 195;ALA A 196;GLY A 106;ILE A 188;ILE A 199","None","0.85A","3s45B-4hvlA:undetectable","3s45B-4hvlA:13.83"],["3SUE_B_SUEB1201_1","NS3 PROTEASE, NS4A PROTEIN","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"HIS A 123;ASP A  92;GLY A 332;SER A 334;ALA A 204"," ZN A 506 ( 3.3A);None;ACT A 512 (-3.5A); ZN A 506 ( 2.2A);ACT A 512 ( 4.7A)","1.02A","3sueB-4hvlA:undetectable","3sueB-4hvlA:19.53"],["3SUF_A_SUEA1201_1","NS3 PROTEASE, NS4A PROTEIN","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"HIS A 123;ASP A  92;GLY A 332;SER A 334;ALA A 204"," ZN A 506 ( 3.3A);None;ACT A 512 (-3.5A); ZN A 506 ( 2.2A);ACT A 512 ( 4.7A)","0.94A","3sufA-4hvlA:undetectable","3sufA-4hvlA:21.49"],["3SUF_C_SUEC1201_1","NS3 PROTEASE, NS4A PROTEIN","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"HIS A 123;ASP A  92;GLY A 332;SER A 334;ALA A 204"," ZN A 506 ( 3.3A);None;ACT A 512 (-3.5A); ZN A 506 ( 2.2A);ACT A 512 ( 4.7A)","1.07A","3sufC-4hvlA:undetectable","3sufC-4hvlA:21.49"],["3W1W_A_CHDA1504_0","FERROCHELATASE, MITOCHONDRIAL","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",4,"PRO A 352;LEU A 354;ILE A 347;ARG A 362","None","1.45A","3w1wA-4hvlA:undetectable","3w1wA-4hvlA:20.48"],["4MM8_A_RFXA603_1","TRANSPORTER","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"VAL A  90;ALA A  89;GLY A 133;ASP A  92;THR A 127","None","1.17A","4mm8A-4hvlA:undetectable","4mm8A-4hvlA:20.86"],["4NKV_C_AERC601_2","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",4,"LEU A 153;GLU A 203;VAL A 218;ALA A 221","None; ZN A 501 ( 3.0A);None;None","1.14A","4nkvC-4hvlA:undetectable","4nkvC-4hvlA:18.51"],["4Q5M_A_ROCA1101_1","PROTEASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"GLY A 195;ILE A 188;THR A  39;VAL A 233;ILE A 201","None;None;IMD A 509 ( 3.8A);None;None","0.96A","4q5mA-4hvlA:undetectable","4q5mA-4hvlA:20.38"],["4QW0_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",4,"THR A 390;ALA A 388;THR A 366;ALA A 367","None","1.03A","4qw0K-4hvlA:undetectable","4qw0K-4hvlA:20.71"],["4QW0_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",4,"THR A 390;ALA A 388;THR A 366;ALA A 367","None","1.03A","4qw0Y-4hvlA:undetectable","4qw0Y-4hvlA:20.71"],["4V1F_A_BQ1A1087_0","F0F1 ATP SYNTHASE SUBUNIT C","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",3,"GLU A  76;ALA A  77;PHE A  80","None","0.60A","4v1fA-4hvlA:undetectable","4v1fA-4hvlA:13.72"],["4V1F_C_BQ1C1087_0","F0F1 ATP SYNTHASE SUBUNIT C","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",3,"GLU A  76;ALA A  77;PHE A  80","None","0.64A","4v1fC-4hvlA:undetectable","4v1fC-4hvlA:13.72"],["5E5J_A_017A201_1","PROTEASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"GLY A 195;ALA A 196;GLY A 106;ILE A 188;ILE A 199","None","0.81A","5e5jA-4hvlA:undetectable","5e5jA-4hvlA:13.71"],["5E5K_B_017B201_2","HIV-1 PROTEASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"GLY A 195;ALA A 196;GLY A 106;ILE A 188;ILE A 199","None","0.81A","5e5kB-4hvlA:undetectable","5e5kB-4hvlA:13.71"],["5G44_A_YTZA1512_1","NUCLEAR RECEPTOR ROR-GAMMA","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"LEU A 194;LEU A 151;ALA A 225;VAL A 233;ALA A  89","IMD A 508 ( 4.4A);None;None;None;None","1.40A","5g44A-4hvlA:undetectable","5g44A-4hvlA:16.97"],["5IGJ_A_CTYA402_2","MACROLIDE 2'-PHOSPHOTRANSFERASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",4,"PRO A 289;LEU A 278;TYR A 339;PHE A 335","None","1.39A","5igjA-4hvlA:undetectable","5igjA-4hvlA:24.07"],["5JWA_A_ACTA609_0","NADH DEHYDROGENASE, PUTATIVE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",3,"VAL A 299;SER A 295;TRP A 298","None","1.02A","5jwaA-4hvlA:undetectable","5jwaA-4hvlA:19.19"],["5LF3_K_BO2K305_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-1","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"ALA A 367;ALA A 365;GLY A 379;GLY A 300;ALA A 301","None","0.88A","5lf3K-4hvlA:undetectable;5lf3L-4hvlA:undetectable","5lf3K-4hvlA:21.59;5lf3L-4hvlA:21.48"],["5LF3_Y_BO2Y305_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-1","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"ALA A 367;ALA A 365;GLY A 379;GLY A 300;ALA A 301","None","0.89A","5lf3Y-4hvlA:undetectable;5lf3Z-4hvlA:undetectable","5lf3Y-4hvlA:21.59;5lf3Z-4hvlA:21.48"],["5LF7_K_6V8K305_0","PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-5","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"ALA A 367;ALA A 365;GLY A 379;GLY A 300;ALA A 301","None","0.90A","5lf7K-4hvlA:undetectable;5lf7L-4hvlA:undetectable","5lf7K-4hvlA:21.59;5lf7L-4hvlA:21.48"],["5LF7_Y_6V8Y306_0","PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-5","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"ALA A 367;ALA A 365;GLY A 379;GLY A 300;ALA A 301","None","0.90A","5lf7Y-4hvlA:undetectable;5lf7Z-4hvlA:undetectable","5lf7Y-4hvlA:21.59;5lf7Z-4hvlA:21.48"],["5MM4_B_TA1B501_1","TUBULIN BETA CHAIN","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"VAL A  90;LEU A 321;ALA A 338;SER A 341;THR A 309","None","1.17A","5mm4B-4hvlA:undetectable","5mm4B-4hvlA:12.40"],["5T2Z_B_017B201_2","PROTEASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"GLY A 133;ALA A 132;VAL A  88;SER A 152;ILE A 150","None","0.74A","5t2zB-4hvlA:undetectable","5t2zB-4hvlA:15.32"],["6DH3_A_017A101_0","PROTEASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"GLY A 195;ALA A 196;GLY A 106;ILE A 188;ILE A 199","None","0.91A","6dh3A-4hvlA:undetectable","6dh3A-4hvlA:16.15"],["6HWD_K_BO2K301_0","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"ALA A 367;ALA A 365;GLY A 379;GLY A 300;ALA A 301","None","0.87A","6hwdK-4hvlA:undetectable;6hwdL-4hvlA:undetectable","6hwdK-4hvlA:12.78;6hwdL-4hvlA:12.33"],["6HWD_Y_BO2Y301_0","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"ALA A 367;ALA A 365;GLY A 379;GLY A 300;ALA A 301","None","0.87A","6hwdY-4hvlA:undetectable;6hwdZ-4hvlA:undetectable","6hwdY-4hvlA:12.78;6hwdZ-4hvlA:12.33"],["6IEY_A_CLMA401_0","ESTERASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",5,"ILE A 234;ALA A 271;GLY A 238;SER A 293;ALA A 336","None;None;ACT A 512 ( 4.3A);None;None","1.29A","6ieyA-4hvlA:4.0;6ieyB-4hvlA:3.9","6ieyA-4hvlA:22.86;6ieyB-4hvlA:22.86"],["6JNH_A_ASCA202_0","PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",3,"ASN A 230;PRO A 356;GLN A 358","None","0.90A","6jnhA-4hvlA:undetectable","6jnhA-4hvlA:17.46"],["6JOG_A_ASCA202_0","PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE","4hvl","MEMBRANE-ANCHORED MYCOSIN MYCP1","Mycolicibacterium thermoresistibile",3,"ASN A 230;PRO A 356;GLN A 358","None","0.92A","6jogA-4hvlA:undetectable","6jogA-4hvlA:17.46"]]