SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		5 / 12 LEU A  63
LEU A 133
GLY A 134
VAL A 154
ALA A 153
 None
 1.13A 1tlsA-4hvmA:
undetectable		 1tlsA-4hvmA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		5 / 12 LEU A  63
LEU A 133
GLY A 134
VAL A 154
ALA A 153
 None
 1.15A 1tlsB-4hvmA:
undetectable		 1tlsB-4hvmA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		5 / 11 ALA A 244
ALA A 247
LEU A 274
SER A 239
LEU A 240
 None
 1.07A 2bxeB-4hvmA:
undetectable		 2bxeB-4hvmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		5 / 12 LEU A  63
LEU A 133
GLY A 134
VAL A 154
ALA A 153
 None
 1.00A 2kceB-4hvmA:
undetectable		 2kceB-4hvmA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		5 / 12 LEU A  63
HIS A 122
LEU A 151
GLY A  37
LEU A 142
 None
 1.25A 3okxB-4hvmA:
undetectable		 3okxB-4hvmA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		5 / 12 PHE A  60
PHE A 162
TYR A 167
LEU A 121
VAL A 119
 None
 1.40A 3u9fP-4hvmA:
8.9
3u9fS-4hvmA:
8.7		 3u9fP-4hvmA:
17.49
3u9fS-4hvmA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		4 / 8 ALA A 144
LEU A 360
TYR A 148
ARG A  36
 None
None
None
SO4  A 502 (-3.5A)
 1.02A 4ijiF-4hvmA:
undetectable		 4ijiF-4hvmA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		4 / 8 LEU A 121
VAL A 154
LEU A 141
LEU A 142
 None
 0.96A 4l1xA-4hvmA:
undetectable		 4l1xA-4hvmA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		3 / 3 ASP A 430
TRP A  23
SER A 417
 None
 1.00A 4lrhA-4hvmA:
undetectable		 4lrhA-4hvmA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		5 / 12 LEU A 179
HIS A 177
VAL A 184
LEU A 280
LEU A 284
 None
 1.35A 4yvpB-4hvmA:
undetectable		 4yvpB-4hvmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		5 / 12 ILE A 427
LEU A 421
GLY A 238
LEU A 227
THR A 228
 None
 1.15A 5byjA-4hvmA:
undetectable		 5byjA-4hvmA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		4 / 5 ARG A 296
THR A 412
ALA A 351
ASP A 410
 None
 1.32A 5mfxA-4hvmA:
undetectable		 5mfxA-4hvmA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		5 / 9 THR A 318
GLY A 321
ALA A 320
GLY A 300
LEU A 274
 None
 1.28A 5vw4A-4hvmA:
undetectable		 5vw4A-4hvmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		4 / 6 GLN A 319
PHE A 322
PHE A 299
LEU A 274
 None
 1.13A 5zcoP-4hvmA:
undetectable
5zcoW-4hvmA:
undetectable		 5zcoP-4hvmA:
18.89
5zcoW-4hvmA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4hvm TLMII
(Streptoalloteich
us
hindustanus) 		5 / 12 GLY A  19
SER A 275
VAL A 298
VAL A 335
ASP A 334
 None
 1.22A 6bxlB-4hvmA:
undetectable		 6bxlB-4hvmA:
21.54