SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hvq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 4hvq 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		3 / 3 TRP A 123
TYR A  50
LEU A 131
 None
 1.08A 1kxhA-4hvqA:
undetectable		 1kxhA-4hvqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4hvq 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		4 / 8 TRP A  31
VAL A  40
LEU A 107
LEU A  62
 None
 0.88A 3u5kA-4hvqA:
undetectable		 3u5kA-4hvqA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4hvq 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		4 / 7 TRP A  31
VAL A  40
LEU A 107
LEU A  62
 None
 0.87A 3u5kB-4hvqA:
undetectable		 3u5kB-4hvqA:
19.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4hvq 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		7 / 7 HIS A  51
ASP A  53
GLU A  57
HIS A  95
PRO A  97
VAL A 108
GLU A 110
 FE2  A 201 (-3.0A)
None
FE2  A 201 (-2.3A)
FE2  A 201 (-3.4A)
None
None
FE2  A 201 ( 4.9A)
 0.36A 4hvrA-4hvqA:
26.1		 4hvrA-4hvqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4hvq 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		5 / 7 HIS A  95
ASP A  53
GLU A  57
VAL A 108
GLU A 110
 FE2  A 201 (-3.4A)
None
FE2  A 201 (-2.3A)
None
FE2  A 201 ( 4.9A)
 1.42A 4hvrA-4hvqA:
26.1		 4hvrA-4hvqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4hvq 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		3 / 3 HIS A  17
GLU A  16
TRP A  13
 None
 0.66A 5odiD-4hvqA:
undetectable		 5odiD-4hvqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4hvq 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		3 / 3 HIS A  17
GLU A  16
TRP A  13
 None
 0.60A 5odqD-4hvqA:
undetectable		 5odqD-4hvqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4hvq 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		3 / 3 HIS A  17
GLU A  16
TRP A  13
 None
 0.59A 5odrD-4hvqA:
undetectable		 5odrD-4hvqA:
21.91