SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hvt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 10 GLY A 151
GLU A  31
LEU A  36
GLU A 676
PRO A 654
 None
 1.32A 1cmcA-4hvtA:
undetectable
1cmcB-4hvtA:
undetectable		 1cmcA-4hvtA:
8.78
1cmcB-4hvtA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		4 / 4 GLY A 683
ASP A 649
GLY A 657
THR A  43
 None
 0.74A 1hxbB-4hvtA:
undetectable		 1hxbB-4hvtA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		4 / 7 PHE A 399
ALA A 365
PHE A 354
PHE A 363
 None
 1.09A 1lqtA-4hvtA:
undetectable		 1lqtA-4hvtA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		4 / 7 PHE A 399
ALA A 365
PHE A 354
PHE A 363
 None
 1.09A 1lquA-4hvtA:
undetectable		 1lquA-4hvtA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 11 GLY A 151
GLU A  31
LEU A  36
GLU A 676
PRO A 654
 None
 1.40A 1mjqA-4hvtA:
undetectable
1mjqB-4hvtA:
undetectable		 1mjqA-4hvtA:
8.93
1mjqB-4hvtA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 10 GLU A  31
LEU A  36
GLU A 676
PRO A 654
GLY A 151
 None
 1.38A 1mjqC-4hvtA:
undetectable
1mjqD-4hvtA:
undetectable		 1mjqC-4hvtA:
8.93
1mjqD-4hvtA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 10 GLY A 151
GLU A  31
LEU A  36
GLU A 676
PRO A 654
 None
 1.39A 1mjqG-4hvtA:
undetectable
1mjqH-4hvtA:
undetectable		 1mjqG-4hvtA:
8.93
1mjqH-4hvtA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		4 / 7 THR A 357
SER A 402
PHE A 354
LEU A 322
 None
 1.12A 1qcaA-4hvtA:
undetectable		 1qcaA-4hvtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 12 ALA A 530
GLY A 518
GLY A 519
ILE A 533
ASP A 619
 None
 0.94A 1sqfA-4hvtA:
undetectable		 1sqfA-4hvtA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 12 ALA A 530
GLY A 519
ILE A 533
ASP A 619
GLY A 612
 None
 1.00A 1sqfA-4hvtA:
undetectable		 1sqfA-4hvtA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 12 VAL A 490
SER A 566
GLY A 612
ILE A 623
TYR A 626
 None
 1.40A 1xvaA-4hvtA:
undetectable		 1xvaA-4hvtA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		3 / 3 THR A 413
THR A 422
PRO A 421
 EDO  A 806 ( 4.2A)
None
EDO  A 806 ( 4.8A)
 0.83A 209dC-4hvtA:
undetectable		 209dC-4hvtA:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 12 ILE A 516
ALA A 538
GLY A 487
VAL A 490
GLY A 568
 None
 1.03A 2qe6B-4hvtA:
undetectable		 2qe6B-4hvtA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 12 ASN A 263
VAL A 243
TYR A 269
MET A 288
TRP A 304
 None
 1.36A 2zvjA-4hvtA:
undetectable		 2zvjA-4hvtA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		3 / 3 TRP A 504
VAL A 572
ARG A 535
 None
 0.89A 3b0wA-4hvtA:
undetectable		 3b0wA-4hvtA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		3 / 3 GLU A 690
SER A 646
VAL A 647
 None
 0.76A 3eeoA-4hvtA:
2.7		 3eeoA-4hvtA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		4 / 4 GLY A 683
ASP A 649
GLY A 657
THR A  43
 None
 0.69A 3k4vC-4hvtA:
undetectable		 3k4vC-4hvtA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		3 / 3 TYR A  84
TYR A 144
GLU A 407
 CL  A 807 (-4.9A)
None
None
 0.70A 3pfgA-4hvtA:
undetectable		 3pfgA-4hvtA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		4 / 6 GLN A  94
ASP A 679
GLU A  47
LEU A 688
 None
 1.00A 4ax8A-4hvtA:
undetectable		 4ax8A-4hvtA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		3 / 3 PHE A  67
ASP A  69
ARG A 498
 None
 0.89A 4eahF-4hvtA:
undetectable		 4eahF-4hvtA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		3 / 3 PHE A  67
ASP A  69
ARG A 498
 None
 0.89A 4eahG-4hvtA:
undetectable		 4eahG-4hvtA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 12 SER A 212
TYR A 214
ASP A 154
TRP A 607
GLY A 604
 None
 1.00A 4iilA-4hvtA:
3.4		 4iilA-4hvtA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		4 / 5 ILE A 562
LEU A 560
GLU A 483
VAL A 467
 None
 0.94A 4nkxB-4hvtA:
undetectable		 4nkxB-4hvtA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 9 VAL A 572
ILE A 462
VAL A 545
ALA A 544
ALA A 575
 None
 1.29A 4oqrA-4hvtA:
undetectable		 4oqrA-4hvtA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 12 GLY A 657
THR A 672
ASP A 645
PHE A 601
ILE A 659
 None
 1.04A 4pghD-4hvtA:
undetectable		 4pghD-4hvtA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		4 / 5 VAL A 647
TYR A 485
ILE A 516
PRO A 591
 None
 1.26A 4ze1A-4hvtA:
3.3		 4ze1A-4hvtA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		3 / 3 PRO A 110
ILE A 116
SER A 106
 None
 0.41A 5fsaA-4hvtA:
undetectable		 5fsaA-4hvtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 12 ILE A 472
GLY A 471
SER A 417
ILE A 418
TYR A 447
 None
 1.26A 5igvA-4hvtA:
2.4		 5igvA-4hvtA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		5 / 12 ILE A 472
GLY A 471
SER A 417
ILE A 418
TYR A 447
 None
 1.20A 5igwA-4hvtA:
undetectable		 5igwA-4hvtA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		4 / 8 TYR A 464
LYS A 452
THR A 480
ILE A 550
 None
 1.00A 5jhdE-4hvtA:
undetectable
5jhdG-4hvtA:
undetectable		 5jhdE-4hvtA:
16.71
5jhdG-4hvtA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		4 / 6 ILE A 418
VAL A 505
TYR A 468
VAL A 467
 None
 0.99A 5jwaH-4hvtA:
undetectable		 5jwaH-4hvtA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		4 / 4 GLU A  47
THR A  46
GLU A 661
HIS A 656
 None
 1.50A 5utuF-4hvtA:
1.6		 5utuF-4hvtA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		3 / 3 TYR A 699
ALA A 587
LEU A 481
 None
 0.76A 6d9kF-4hvtA:
3.7		 6d9kF-4hvtA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4hvt POST-PROLINE
CLEAVING ENZYME
(Rickettsia
typhi) 		4 / 8 VAL A 236
TYR A 240
ASN A 271
TYR A 269
 None
 1.23A 6gneB-4hvtA:
5.2		 6gneB-4hvtA:
21.95