SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hw6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		3 / 3 ALA A 195
VAL A 190
TRP A 189
 CL  A 506 ( 3.8A)
None
None
 0.84A 1bdwA-4hw6A:
undetectable
1bdwB-4hw6A:
undetectable		 1bdwA-4hw6A:
5.20
1bdwB-4hw6A:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		3 / 3 ALA A 195
VAL A 190
TRP A 174
 CL  A 506 ( 3.8A)
None
None
 0.70A 1c4dC-4hw6A:
undetectable
1c4dD-4hw6A:
undetectable		 1c4dC-4hw6A:
5.20
1c4dD-4hw6A:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		3 / 3 TRP A 174
ALA A 195
VAL A 190
 None
CL  A 506 ( 3.8A)
None
 0.73A 1c4dC-4hw6A:
undetectable
1c4dD-4hw6A:
undetectable		 1c4dC-4hw6A:
5.20
1c4dD-4hw6A:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		5 / 12 VAL A  96
PHE A  75
ILE A  86
ILE A  52
VAL A  54
 None
 1.22A 1r5lA-4hw6A:
undetectable		 1r5lA-4hw6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		3 / 3 ASP A 452
PHE A 170
ASN A 154
 None
 0.88A 1sg9B-4hw6A:
undetectable		 1sg9B-4hw6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		3 / 3 ALA A 195
VAL A 190
TRP A 174
 CL  A 506 ( 3.8A)
None
None
 0.68A 1tkqB-4hw6A:
undetectable		 1tkqB-4hw6A:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 5 PHE A 201
LEU A 147
PHE A 178
SER A 438
 None
 1.32A 1wrkB-4hw6A:
undetectable		 1wrkB-4hw6A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 THR A 245
PHE A 250
THR A 251
ASP A 179
 None
 1.13A 2kotB-4hw6A:
undetectable		 2kotB-4hw6A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 0.95A 2obvA-4hw6A:
undetectable		 2obvA-4hw6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 0.94A 2p02A-4hw6A:
undetectable		 2p02A-4hw6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		3 / 3 ARG A 331
THR A 362
VAL A 347
 None
 0.90A 2q64A-4hw6A:
undetectable		 2q64A-4hw6A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 5 VAL A 311
GLN A 270
PHE A 221
ARG A 336
 CL  A 507 ( 4.2A)
None
None
None
 1.27A 3bjwB-4hw6A:
undetectable		 3bjwB-4hw6A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		5 / 12 ALA A 262
ALA A 266
VAL A 267
ILE A 213
THR A 239
 None
CL  A 507 ( 3.9A)
None
None
None
 1.08A 3czhA-4hw6A:
undetectable		 3czhA-4hw6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		5 / 12 ALA A 262
ALA A 266
VAL A 267
ILE A 213
THR A 239
 None
CL  A 507 ( 3.9A)
None
None
None
 1.10A 3czhB-4hw6A:
undetectable		 3czhB-4hw6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		5 / 11 VAL A 332
ALA A 319
PHE A 391
ILE A 310
ARG A 400
 None
 1.38A 3n23A-4hw6A:
undetectable		 3n23A-4hw6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		5 / 12 GLU A 464
TYR A 141
ALA A 412
ASP A 424
VAL A 143
 None
 1.20A 3nvkF-4hw6A:
undetectable
3nvkJ-4hw6A:
undetectable		 3nvkF-4hw6A:
21.89
3nvkJ-4hw6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		5 / 12 TYR A 141
GLY A 425
ALA A 412
ASP A 424
VAL A 143
 None
 1.17A 3nvkF-4hw6A:
undetectable
3nvkJ-4hw6A:
undetectable		 3nvkF-4hw6A:
21.89
3nvkJ-4hw6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 VAL A 375
VAL A 399
TYR A 441
ILE A 439
 None
 0.92A 3remA-4hw6A:
undetectable		 3remA-4hw6A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 VAL A 375
VAL A 399
TYR A 441
ILE A 439
 None
 0.93A 3remB-4hw6A:
undetectable		 3remB-4hw6A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 0.93A 4kttA-4hw6A:
undetectable		 4kttA-4hw6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 1.00A 4kttC-4hw6A:
undetectable		 4kttC-4hw6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 0.94A 4ndnA-4hw6A:
undetectable		 4ndnA-4hw6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 7 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 0.98A 4ndnC-4hw6A:
undetectable		 4ndnC-4hw6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 7 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 1.05A 4odjA-4hw6A:
undetectable		 4odjA-4hw6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		5 / 12 GLY A  62
ILE A 104
VAL A 114
ARG A  63
ILE A  94
 None
 1.04A 4q5mA-4hw6A:
undetectable		 4q5mA-4hw6A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		5 / 12 PRO A 289
ILE A 274
VAL A 219
ASP A 179
ASN A 181
 None
 1.39A 4xe0A-4hw6A:
undetectable		 4xe0A-4hw6A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 0.93A 5a1iA-4hw6A:
undetectable		 5a1iA-4hw6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 7 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 0.93A 5a1iA-4hw6A:
undetectable		 5a1iA-4hw6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 1.02A 6fbnB-4hw6A:
undetectable		 6fbnB-4hw6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 0.95A 6fboA-4hw6A:
undetectable		 6fboA-4hw6A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 0.99A 6fcbA-4hw6A:
undetectable		 6fcbA-4hw6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 8 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 0.93A 6fcdA-4hw6A:
undetectable		 6fcdA-4hw6A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN
(Bacteroides
ovatus) 		4 / 7 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 0.92A 6g6rA-4hw6A:
undetectable		 6g6rA-4hw6A:
22.29