SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hw8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		5 / 12 MET A 375
LEU A 224
ILE A 410
PHE A 205
PHE A 197
 None
 1.36A 1y0xX-4hw8A:
undetectable		 1y0xX-4hw8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		4 / 8 VAL A 173
THR A 293
PRO A 292
LEU A 156
 None
 0.96A 1z2bB-4hw8A:
undetectable		 1z2bB-4hw8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		4 / 6 ILE A 372
PRO A 381
LEU A 226
ILE A 406
 None
 0.87A 2q83B-4hw8A:
undetectable		 2q83B-4hw8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		5 / 12 ASN A 371
PHE A 101
GLY A 307
ILE A 100
ASP A  51
 None
 1.45A 3a25A-4hw8A:
undetectable		 3a25A-4hw8A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		4 / 8 TYR A 158
ASN A 159
LYS A 160
LYS A 161
 None
 1.29A 3bjwD-4hw8A:
undetectable		 3bjwD-4hw8A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		4 / 5 GLN A 362
THR A 154
GLU A 152
HIS A 105
 None
None
MAL  A 506 (-3.4A)
None
 1.34A 3glqB-4hw8A:
undetectable		 3glqB-4hw8A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		5 / 9 PHE A 268
VAL A 265
GLY A 263
VAL A 269
ASN A 159
 None
 1.41A 3kmoA-4hw8A:
undetectable		 3kmoA-4hw8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		4 / 6 PHE A 197
PHE A 205
TYR A 201
VAL A 378
 None
 1.29A 3lb3A-4hw8A:
undetectable		 3lb3A-4hw8A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		4 / 6 PHE A 197
PHE A 205
TYR A 201
VAL A 378
 None
 1.24A 3lb3B-4hw8A:
undetectable		 3lb3B-4hw8A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		3 / 3 ARG A 306
TYR A 201
ASN A 196
 None
None
MAL  A 506 (-3.7A)
 0.73A 4ffwB-4hw8A:
undetectable		 4ffwB-4hw8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		4 / 8 VAL A 231
ASN A 227
GLN A 223
ILE A 211
 None
 0.94A 4iilA-4hw8A:
3.1		 4iilA-4hw8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		5 / 12 LEU A 310
ILE A 100
LEU A 122
LEU A 147
MET A 324
 None
 0.95A 5nfjB-4hw8A:
undetectable		 5nfjB-4hw8A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		5 / 12 LEU A 310
ILE A 100
LEU A 122
LEU A 147
MET A 324
 None
 0.95A 5nfjC-4hw8A:
undetectable		 5nfjC-4hw8A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		4 / 8 THR A  67
ASN A  44
PRO A  43
TYR A  66
 None
 1.27A 5v4vA-4hw8A:
undetectable		 5v4vA-4hw8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE
(Staphylococcus
aureus) 		4 / 8 THR A  67
ASN A  44
PRO A  43
TYR A  66
 None
 1.25A 5v4vB-4hw8A:
undetectable		 5v4vB-4hw8A:
22.07