SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hw9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4hw9 MECHANOSENSITIVE
CHANNEL MSCS
(Helicobacter
pylori) 		4 / 7 LEU A  89
VAL A  92
GLY A  93
VAL A  61
 None
 0.87A 1t88A-4hw9A:
undetectable		 1t88A-4hw9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4hw9 MECHANOSENSITIVE
CHANNEL MSCS
(Helicobacter
pylori) 		4 / 6 GLY A 129
ILE A 127
GLU A 126
ILE A 165
 None
 0.93A 3a7eA-4hw9A:
undetectable		 3a7eA-4hw9A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4hw9 MECHANOSENSITIVE
CHANNEL MSCS
(Helicobacter
pylori) 		5 / 9 LEU A 144
SER A 128
ILE A 125
ILE A 114
GLY A 109
 None
 1.14A 3cv9A-4hw9A:
undetectable		 3cv9A-4hw9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4hw9 MECHANOSENSITIVE
CHANNEL MSCS
(Helicobacter
pylori) 		4 / 7 ARG A 174
ILE A 204
LEU A 243
THR A 225
 None
 1.08A 4mmcA-4hw9A:
2.9		 4mmcA-4hw9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4hw9 MECHANOSENSITIVE
CHANNEL MSCS
(Helicobacter
pylori) 		4 / 5 LEU A 189
PHE A 224
ILE A 187
ILE A 214
 None
 1.08A 5dzk4-4hw9A:
undetectable
5dzkg-4hw9A:
undetectable
5dzkm-4hw9A:
undetectable
5dzkn-4hw9A:
undetectable		 5dzk4-4hw9A:
6.25
5dzkg-4hw9A:
21.41
5dzkm-4hw9A:
21.63
5dzkn-4hw9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4hw9 MECHANOSENSITIVE
CHANNEL MSCS
(Helicobacter
pylori) 		5 / 12 ILE A 212
GLY A 213
ILE A 214
ILE A 247
ILE A 194
 None
 0.90A 6emuB-4hw9A:
undetectable		 6emuB-4hw9A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4hw9 MECHANOSENSITIVE
CHANNEL MSCS
(Helicobacter
pylori) 		5 / 12 ILE A 212
GLY A 213
ILE A 214
ILE A 247
ILE A 194
 None
 0.89A 6emuC-4hw9A:
undetectable		 6emuC-4hw9A:
25.80