SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E1G_B_LNLB701_2 (PROSTAGLANDIN G/H SYNTHASE 2)	4hwc	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1 (Arabidopsis thaliana)	4 / 7	VAL A 227 VAL A 231 LEU A 234 VAL A 194	None	1.01A	4e1gB-4hwcA: 2.3	4e1gB-4hwcA: 8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWV_A_BCZA513_1 (NEURAMINIDASE)	4hwc	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1 (Arabidopsis thaliana)	3 / 3	ARG A 170 GLU A 203 ARG A 174	None	0.88A	4mwvA-4hwcA: undetectable	4mwvA-4hwcA: 13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CSH_B_ACTB401_0 (CASEIN KINASE II SUBUNIT ALPHA)	4hwc	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1 (Arabidopsis thaliana)	4 / 5	ARG A 170 ARG A 174 LEU A 171 VAL A 196	None	1.24A	5cshB-4hwcA: undetectable	5cshB-4hwcA: 14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OS7_B_ACTB401_0 (CASEIN KINASE II SUBUNIT ALPHA)	4hwc	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1 (Arabidopsis thaliana)	4 / 5	ARG A 170 ARG A 174 LEU A 171 VAL A 196	None	1.21A	5os7B-4hwcA: undetectable	5os7B-4hwcA: 14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GMD_A_ACTA401_0 (CASEIN KINASE II SUBUNIT ALPHA)	4hwc	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1 (Arabidopsis thaliana)	4 / 5	ARG A 170 ARG A 174 LEU A 171 VAL A 196	None	1.21A	6gmdA-4hwcA: undetectable	6gmdA-4hwcA: 14.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4E1G_B_LNLB701_2","PROSTAGLANDIN G\/H SYNTHASE 2","4hwc","BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1","Arabidopsis thaliana",4,"VAL A 227;VAL A 231;LEU A 234;VAL A 194","None","1.01A","4e1gB-4hwcA:2.3","4e1gB-4hwcA:8.36"],["4MWV_A_BCZA513_1","NEURAMINIDASE","4hwc","BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1","Arabidopsis thaliana",3,"ARG A 170;GLU A 203;ARG A 174","None","0.88A","4mwvA-4hwcA:undetectable","4mwvA-4hwcA:13.37"],["5CSH_B_ACTB401_0","CASEIN KINASE II SUBUNIT ALPHA","4hwc","BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1","Arabidopsis thaliana",4,"ARG A 170;ARG A 174;LEU A 171;VAL A 196","None","1.24A","5cshB-4hwcA:undetectable","5cshB-4hwcA:14.77"],["5OS7_B_ACTB401_0","CASEIN KINASE II SUBUNIT ALPHA","4hwc","BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1","Arabidopsis thaliana",4,"ARG A 170;ARG A 174;LEU A 171;VAL A 196","None","1.21A","5os7B-4hwcA:undetectable","5os7B-4hwcA:14.77"],["6GMD_A_ACTA401_0","CASEIN KINASE II SUBUNIT ALPHA","4hwc","BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1","Arabidopsis thaliana",4,"ARG A 170;ARG A 174;LEU A 171;VAL A 196","None","1.21A","6gmdA-4hwcA:undetectable","6gmdA-4hwcA:14.77"]]