SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4hwe FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 TYR H  96
MET H  94
THR H 113
LEU H 114
 None
 1.40A 2eimJ-4hweH:
undetectable		 2eimJ-4hweH:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4hwe FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 TYR H  96
MET H  94
THR H 113
LEU H 114
 None
 1.37A 2eimW-4hweH:
undetectable		 2eimW-4hweH:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4hwe FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 TYR H  96
MET H  94
THR H 113
LEU H 114
 None
 1.37A 3ag2J-4hweH:
undetectable		 3ag2J-4hweH:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4hwe FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 TYR H  96
MET H  94
THR H 113
LEU H 114
 None
 1.37A 3ag4J-4hweH:
undetectable		 3ag4J-4hweH:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4hwe FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU H 195
GLY H 196
ALA H 131
PRO H 132
 None
 0.48A 3huoA-4hweH:
undetectable		 3huoA-4hweH:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4hwe FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 10 PHE H 128
GLY H 124
THR H 211
VAL H 204
VAL H 213
 None
 1.10A 4jx1B-4hweH:
undetectable		 4jx1B-4hweH:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 4hwe FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 VAL H   3
TYR H  28
ARG H  99
TYR H 108
 None
 0.28A 4m7kH-4hweH:
22.0		 4m7kH-4hweH:
77.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 4hwe FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 4 PHE H 106
ASP H 107
GLY H  36
SER H 105
 None
 1.28A 4xp9C-4hweH:
undetectable		 4xp9C-4hweH:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4hwe FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 ASP H 107
GLY H 104
PRO H 101
TRP H  34
 None
None
None
GOL  H 306 ( 4.1A)
 1.26A 5nn8A-4hweH:
2.3		 5nn8A-4hweH:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hwe FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 TYR H  96
MET H  94
THR H 113
LEU H 114
 None
 1.38A 5x19J-4hweH:
undetectable		 5x19J-4hweH:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hwe FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 TYR H  96
MET H  94
THR H 113
LEU H 114
 None
 1.37A 5z86J-4hweH:
undetectable		 5z86J-4hweH:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4hwe FAB HEAVY CHAIN
(Homo
sapiens) 		6 / 12 VAL H 190
THR H 141
LEU H 165
VAL H 169
GLY H 168
VAL H 217
 None
None
GOL  H 308 ( 4.0A)
None
None
None
 1.48A 6a94B-4hweH:
undetectable		 6a94B-4hweH:
20.55