SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hwg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		4 / 8 TYR A  41
PHE A  59
THR A   6
LEU A  32
 None
 1.24A 1ea1A-4hwgA:
undetectable		 1ea1A-4hwgA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		4 / 7 ASP A 281
GLU A 304
GLU A 287
GLU A 116
 None
 0.98A 1knyA-4hwgA:
undetectable
1knyB-4hwgA:
undetectable		 1knyA-4hwgA:
21.09
1knyB-4hwgA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		4 / 8 GLU A 116
ASP A 281
GLU A 304
GLU A 287
 None
 1.11A 1knyA-4hwgA:
undetectable
1knyB-4hwgA:
undetectable		 1knyA-4hwgA:
21.09
1knyB-4hwgA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		5 / 11 SER A 282
LEU A 174
VAL A 173
PHE A 265
VAL A 269
 None
 1.32A 1q23J-4hwgA:
undetectable		 1q23J-4hwgA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		5 / 10 SER A 282
LEU A 174
VAL A 173
PHE A 265
VAL A 269
 None
 1.40A 1q23K-4hwgA:
undetectable		 1q23K-4hwgA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		5 / 11 SER A 282
LEU A 174
VAL A 173
PHE A 265
VAL A 269
 None
 1.37A 1q23L-4hwgA:
undetectable		 1q23L-4hwgA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		3 / 3 SER A 101
VAL A  81
LEU A  82
 None
 0.66A 1yajG-4hwgA:
undetectable		 1yajG-4hwgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		4 / 8 MET A 170
SER A 166
GLY A  94
MET A 115
 None
 0.87A 2qd3A-4hwgA:
4.1		 2qd3A-4hwgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		3 / 3 SER A 282
GLY A 283
THR A 284
 None
 0.24A 3k9wA-4hwgA:
4.2		 3k9wA-4hwgA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		5 / 12 ILE A 138
VAL A 362
ILE A 358
ILE A 135
ALA A 105
 None
 1.19A 3ohtA-4hwgA:
undetectable
3ohtB-4hwgA:
undetectable		 3ohtA-4hwgA:
23.78
3ohtB-4hwgA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		4 / 6 GLY A 283
THR A 284
GLU A 304
ASP A 281
 None
 0.98A 3ps9A-4hwgA:
2.3		 3ps9A-4hwgA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		5 / 10 ILE A 233
ALA A 275
SER A 280
ILE A 299
TYR A 268
 None
 1.29A 3qgtA-4hwgA:
undetectable		 3qgtA-4hwgA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		4 / 5 ARG A 151
TYR A 152
THR A 146
PRO A 306
 None
 1.48A 4mjqA-4hwgA:
undetectable		 4mjqA-4hwgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		4 / 4 GLY A 167
VAL A 354
PHE A 113
ILE A 361
 None
 0.81A 4xv2B-4hwgA:
undetectable		 4xv2B-4hwgA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		4 / 6 ARG A 305
SER A 282
GLY A  94
THR A   6
 None
 1.05A 5btcA-4hwgA:
undetectable
5btcC-4hwgA:
undetectable
5btcD-4hwgA:
undetectable		 5btcA-4hwgA:
21.85
5btcC-4hwgA:
21.85
5btcD-4hwgA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		4 / 6 SER A 282
GLY A  94
THR A   6
ARG A 305
 None
 1.08A 5btcA-4hwgA:
undetectable
5btcB-4hwgA:
undetectable
5btcC-4hwgA:
undetectable		 5btcA-4hwgA:
21.85
5btcB-4hwgA:
20.20
5btcC-4hwgA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		4 / 5 ARG A 305
GLY A 308
THR A 146
GLU A 307
 None
 1.19A 5btiA-4hwgA:
undetectable
5btiB-4hwgA:
2.4		 5btiA-4hwgA:
21.85
5btiB-4hwgA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		4 / 5 PHE A 265
SER A 264
GLN A 272
ASP A 281
 None
 1.34A 5kpcA-4hwgA:
undetectable		 5kpcA-4hwgA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		3 / 3 THR A 144
MET A 115
HIS A 114
 None
 0.75A 5uunA-4hwgA:
undetectable		 5uunA-4hwgA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		3 / 3 THR A  96
GLU A  13
HIS A  34
 None
None
PO4  A 400 (-3.9A)
 0.63A 5xioA-4hwgA:
3.6		 5xioA-4hwgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		3 / 3 THR A  96
GLU A  13
HIS A  34
 None
None
PO4  A 400 (-3.9A)
 0.64A 5xiqB-4hwgA:
4.1		 5xiqB-4hwgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Rickettsia
bellii) 		3 / 3 THR A  96
GLU A  13
HIS A  34
 None
None
PO4  A 400 (-3.9A)
 0.66A 5xiqD-4hwgA:
2.4		 5xiqD-4hwgA:
22.26