SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hwi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
4 / 5 THR A  13
THR A  14
GLU A 231
HIS A 227
None
1.33A 1d4fB-4hwiA:
undetectable
1d4fB-4hwiA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
3 / 3 THR A  66
PRO A  63
THR A  64
None
0.94A 1dscC-4hwiA:
undetectable
1dscC-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
3 / 3 THR A  64
THR A  66
PRO A  63
None
0.72A 1dscC-4hwiA:
undetectable
1dscC-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
3 / 3 THR A  64
THR A  66
PRO A  63
None
0.88A 1fjaC-4hwiA:
undetectable
1fjaC-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
3 / 3 THR A  64
THR A  66
PRO A  63
None
0.88A 1fjaD-4hwiA:
undetectable
1fjaD-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
3 / 3 THR A  64
THR A  66
PRO A  63
None
0.87A 1unjL-4hwiA:
undetectable
1unjL-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
3 / 3 THR A  66
PRO A  63
THR A  64
None
0.86A 1unjR-4hwiA:
undetectable
1unjR-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
3 / 3 THR A  64
THR A  66
PRO A  63
None
0.84A 1unjW-4hwiA:
undetectable
1unjW-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
3 / 3 THR A  66
PRO A  63
THR A  64
None
0.87A 1unjX-4hwiA:
undetectable
1unjX-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
3 / 3 THR A  66
PRO A  63
THR A  64
None
0.87A 1unmE-4hwiA:
undetectable
1unmE-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 12 ILE A 334
ILE A 209
VAL A 207
PHE A 205
LEU A 200
None
1.11A 1xozA-4hwiA:
undetectable
1xozA-4hwiA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
4 / 8 VAL A  67
THR A  66
PHE A  92
THR A  64
None
1.24A 2kotB-4hwiA:
undetectable
2kotB-4hwiA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 12 ILE A 297
LEU A 274
ILE A 343
PRO A 344
PHE A 310
None
1.07A 2ygqA-4hwiA:
undetectable
2ygqA-4hwiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
4 / 5 VAL A 238
THR A 295
THR A 265
ARG A 264
None
0.91A 3bjwA-4hwiA:
undetectable
3bjwA-4hwiA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
4 / 4 PHE A 245
LYS A 246
ILE A 291
THR A 295
None
0.90A 3ia4B-4hwiA:
undetectable
3ia4B-4hwiA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 11 ILE A  74
ALA A 157
ILE A 172
VAL A 146
VAL A 144
None
0.91A 3kw4A-4hwiA:
undetectable
3kw4A-4hwiA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 10 ILE A 212
ALA A 178
ILE A 197
VAL A 335
VAL A 195
None
0.92A 3me6A-4hwiA:
undetectable
3me6A-4hwiA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
4 / 8 ILE A 212
ALA A 178
VAL A 335
VAL A 195
None
0.80A 3me6B-4hwiA:
undetectable
3me6B-4hwiA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 12 ALA A 148
ILE A 209
ASP A 323
ALA A 320
ASP A 206
None
1.03A 3nvkI-4hwiA:
undetectable
3nvkI-4hwiA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 7 GLY A 202
GLY A 201
SER A 340
LEU A 228
PHE A 233
None
1.45A 3o9mA-4hwiA:
undetectable
3o9mA-4hwiA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
4 / 5 THR A 341
ILE A 346
PHE A 198
LEU A 359
None
1.47A 3tf1A-4hwiA:
undetectable
3tf1A-4hwiA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
4hwi BAG FAMILY MOLECULAR
CHAPERONE REGULATOR
1

(Arabidopsis
thaliana)
4 / 7 PRO B  98
LEU B 134
LEU B 108
ILE B  80
None
0.83A 3u5jA-4hwiB:
2.4
3u5jA-4hwiB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
4hwi BAG FAMILY MOLECULAR
CHAPERONE REGULATOR
1

(Arabidopsis
thaliana)
4 / 8 PRO B  98
LEU B 134
LEU B 108
ILE B  80
None
0.65A 3u5kD-4hwiB:
2.3
3u5kD-4hwiB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 12 ASP A 206
ALA A 180
VAL A 335
SER A 208
THR A 145
None
1.16A 4mm4B-4hwiA:
undetectable
4mm4B-4hwiA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 12 LEU A  11
ASP A 366
VAL A 369
GLY A 201
PRO A 147
None
1.01A 4njuA-4hwiA:
undetectable
4njuA-4hwiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 12 LEU A  11
ASP A 366
VAL A 369
GLY A 201
PRO A 147
None
1.03A 4njuC-4hwiA:
undetectable
4njuC-4hwiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 9 ALA A 266
ARG A 261
ILE A 284
PHE A 293
ILE A 282
None
1.18A 4oknB-4hwiA:
2.3
4oknB-4hwiA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
4 / 7 GLU A 175
THR A  13
GLY A  12
THR A  14
None
0.99A 4qwpB-4hwiA:
undetectable
4qwpB-4hwiA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
6 / 10 GLY A 229
GLY A 230
LYS A 271
SER A 275
SER A 340
ILE A 343
None
1.27A 5aqfA-4hwiA:
58.7
5aqfA-4hwiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
7 / 10 GLY A 230
LYS A 271
SER A 275
GLY A 339
SER A 340
ARG A 342
ILE A 343
None
0.20A 5aqfA-4hwiA:
58.7
5aqfA-4hwiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 10 GLY A 202
GLY A 339
SER A 340
ARG A 342
ILE A 343
None
0.89A 5aqfC-4hwiA:
58.6
5aqfC-4hwiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
6 / 10 GLY A 229
GLY A 230
LYS A 271
SER A 275
SER A 340
ILE A 343
None
1.27A 5aqfC-4hwiA:
58.6
5aqfC-4hwiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
7 / 10 GLY A 230
LYS A 271
SER A 275
GLY A 339
SER A 340
ARG A 342
ILE A 343
None
0.22A 5aqfC-4hwiA:
58.6
5aqfC-4hwiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 10 GLY A 202
SER A 275
GLY A 339
SER A 340
ARG A 342
None
0.91A 5aqyA-4hwiA:
58.4
5aqyA-4hwiA:
85.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
6 / 10 GLY A 229
GLY A 230
LYS A 271
SER A 275
SER A 340
ILE A 343
None
1.29A 5aqyA-4hwiA:
58.4
5aqyA-4hwiA:
85.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 10 GLY A 229
GLY A 339
SER A 340
ARG A 342
ILE A 343
None
0.93A 5aqyA-4hwiA:
58.4
5aqyA-4hwiA:
85.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
7 / 10 GLY A 230
LYS A 271
SER A 275
GLY A 339
SER A 340
ARG A 342
ILE A 343
None
0.22A 5aqyA-4hwiA:
58.4
5aqyA-4hwiA:
85.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)
4hwi BAG FAMILY MOLECULAR
CHAPERONE REGULATOR
1

(Arabidopsis
thaliana)
4 / 5 ARG B 170
ARG B 174
LEU B 171
VAL B 196
None
1.31A 5cshB-4hwiB:
undetectable
5cshB-4hwiB:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
4 / 7 ASN A 235
VAL A 238
VAL A 260
ARG A 264
None
0.72A 5fpdA-4hwiA:
57.9
5fpdA-4hwiA:
90.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
SERINE/THREONINE-PRO
TEIN KINASE MTOR)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
5 / 9 SER A 340
ARG A 342
THR A 226
ASP A 225
PHE A 310
None
1.49A 5gpgB-4hwiA:
undetectable
5gpgB-4hwiA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)
4hwi BAG FAMILY MOLECULAR
CHAPERONE REGULATOR
1

(Arabidopsis
thaliana)
5 / 10 GLY B  97
GLY B 100
LEU B 134
GLU B 136
TYR B  73
None
1.37A 5hwkA-4hwiB:
undetectable
5hwkA-4hwiB:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)
4hwi BAG FAMILY MOLECULAR
CHAPERONE REGULATOR
1

(Arabidopsis
thaliana)
5 / 10 GLY B  97
GLY B 100
LEU B 134
GLU B 136
TYR B  73
None
1.36A 5hwkB-4hwiB:
undetectable
5hwkB-4hwiB:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo
sapiens)
6 / 12 VAL A 238
ASN A 239
ILE A 242
ALA A 243
LYS A 246
VAL A 260
None
1.11A 5j2tC-4hwiA:
undetectable
5j2tC-4hwiA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)
4hwi BAG FAMILY MOLECULAR
CHAPERONE REGULATOR
1

(Arabidopsis
thaliana)
4 / 5 ARG B 170
ARG B 174
LEU B 171
VAL B 196
None
1.30A 5os7B-4hwiB:
undetectable
5os7B-4hwiB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)
4hwi BAG FAMILY MOLECULAR
CHAPERONE REGULATOR
1

(Arabidopsis
thaliana)
4 / 5 ARG B 170
ARG B 174
LEU B 171
VAL B 196
None
1.30A 6gmdA-4hwiB:
undetectable
6gmdA-4hwiB:
19.32