SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NYR_A_THRA1004_0
(THREONYL-TRNA
SYNTHETASE 1)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		8 / 10 MET A 444
CYH A 446
ARG A 475
ASP A 495
HIS A 497
TYR A 573
GLN A 595
HIS A 623
 1B2  A 802 (-2.6A)
ZN  A 801 ( 2.3A)
1B2  A 802 (-2.5A)
1B2  A 802 (-3.6A)
ZN  A 801 ( 3.3A)
None
1B2  A 802 (-3.3A)
ZN  A 801 ( 3.1A)
 0.29A 1nyrA-4hwtA:
49.3		 1nyrA-4hwtA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NYR_B_THRB2004_0
(THREONYL-TRNA
SYNTHETASE 1)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		8 / 10 MET A 444
CYH A 446
ARG A 475
ASP A 495
HIS A 497
TYR A 573
GLN A 595
HIS A 623
 1B2  A 802 (-2.6A)
ZN  A 801 ( 2.3A)
1B2  A 802 (-2.5A)
1B2  A 802 (-3.6A)
ZN  A 801 ( 3.3A)
None
1B2  A 802 (-3.3A)
ZN  A 801 ( 3.1A)
 0.71A 1nyrB-4hwtA:
47.9		 1nyrB-4hwtA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 VAL A 709
VAL A 670
GLU A 665
GLU A 711
LYS A 712
 None
 1.45A 1t6zA-4hwtA:
undetectable		 1t6zA-4hwtA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A 466
SER A 521
TYR A 520
 None
 0.74A 1x70A-4hwtA:
undetectable		 1x70A-4hwtA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 PRO A 575
THR A 533
PRO A 535
 None
 0.62A 2d55C-4hwtA:
undetectable		 2d55C-4hwtA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 TYR A 384
ARG A 394
GLU A 391
VAL A 630
 None
 1.16A 2fl5E-4hwtA:
undetectable
2fl5F-4hwtA:
undetectable		 2fl5E-4hwtA:
18.97
2fl5F-4hwtA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 LEU A 365
ILE A 385
ILE A 634
ALA A 635
 None
 0.58A 2i2zA-4hwtA:
undetectable		 2i2zA-4hwtA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 PHE A 527
ILE A 579
ILE A 594
GLY A 560
 None
 0.88A 2v0mB-4hwtA:
undetectable		 2v0mB-4hwtA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 GLY A 511
ILE A 509
GLU A 508
ASP A 514
 None
 0.86A 3a7eA-4hwtA:
undetectable		 3a7eA-4hwtA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ALA A 388
LEU A 389
THR A 638
ASN A 640
 None
 0.92A 3b6hA-4hwtA:
undetectable		 3b6hA-4hwtA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.22A 3ko0A-4hwtA:
1.2
3ko0B-4hwtA:
1.2
3ko0C-4hwtA:
1.1
3ko0D-4hwtA:
1.1		 3ko0A-4hwtA:
14.49
3ko0B-4hwtA:
14.49
3ko0C-4hwtA:
14.49
3ko0D-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.24A 3ko0A-4hwtA:
1.2
3ko0B-4hwtA:
1.2
3ko0C-4hwtA:
1.1
3ko0D-4hwtA:
1.1		 3ko0A-4hwtA:
14.49
3ko0B-4hwtA:
14.49
3ko0C-4hwtA:
14.49
3ko0D-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.24A 3ko0C-4hwtA:
1.1
3ko0D-4hwtA:
1.1
3ko0E-4hwtA:
1.1
3ko0F-4hwtA:
0.9		 3ko0C-4hwtA:
14.49
3ko0D-4hwtA:
14.49
3ko0E-4hwtA:
14.49
3ko0F-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.20A 3ko0C-4hwtA:
1.1
3ko0D-4hwtA:
1.1
3ko0E-4hwtA:
1.1
3ko0F-4hwtA:
0.9		 3ko0C-4hwtA:
14.49
3ko0D-4hwtA:
14.49
3ko0E-4hwtA:
14.49
3ko0F-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.26A 3ko0E-4hwtA:
1.1
3ko0F-4hwtA:
0.9
3ko0G-4hwtA:
0.8
3ko0H-4hwtA:
1.0		 3ko0E-4hwtA:
14.49
3ko0F-4hwtA:
14.49
3ko0G-4hwtA:
14.49
3ko0H-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.24A 3ko0G-4hwtA:
0.8
3ko0H-4hwtA:
1.0
3ko0I-4hwtA:
1.1
3ko0J-4hwtA:
1.1		 3ko0G-4hwtA:
14.49
3ko0H-4hwtA:
14.49
3ko0I-4hwtA:
14.49
3ko0J-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.27A 3ko0G-4hwtA:
0.8
3ko0H-4hwtA:
1.0
3ko0I-4hwtA:
1.1
3ko0J-4hwtA:
1.1		 3ko0G-4hwtA:
14.49
3ko0H-4hwtA:
14.49
3ko0I-4hwtA:
14.49
3ko0J-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.21A 3ko0A-4hwtA:
1.1
3ko0B-4hwtA:
1.2
3ko0I-4hwtA:
1.1
3ko0J-4hwtA:
1.0		 3ko0A-4hwtA:
14.49
3ko0B-4hwtA:
14.49
3ko0I-4hwtA:
14.49
3ko0J-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.23A 3ko0K-4hwtA:
0.9
3ko0L-4hwtA:
1.0
3ko0M-4hwtA:
1.1
3ko0N-4hwtA:
1.1		 3ko0K-4hwtA:
14.49
3ko0L-4hwtA:
14.49
3ko0M-4hwtA:
14.49
3ko0N-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.22A 3ko0M-4hwtA:
1.1
3ko0N-4hwtA:
1.1
3ko0O-4hwtA:
1.0
3ko0P-4hwtA:
0.8		 3ko0M-4hwtA:
14.49
3ko0N-4hwtA:
14.49
3ko0O-4hwtA:
14.49
3ko0P-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.24A 3ko0K-4hwtA:
0.9
3ko0L-4hwtA:
1.1
3ko0M-4hwtA:
1.1
3ko0N-4hwtA:
1.1		 3ko0K-4hwtA:
14.49
3ko0L-4hwtA:
14.49
3ko0M-4hwtA:
14.49
3ko0N-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.23A 3ko0O-4hwtA:
1.0
3ko0P-4hwtA:
0.9
3ko0Q-4hwtA:
undetectable
3ko0R-4hwtA:
1.1		 3ko0O-4hwtA:
14.49
3ko0P-4hwtA:
14.49
3ko0Q-4hwtA:
14.49
3ko0R-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.18A 3ko0M-4hwtA:
1.1
3ko0N-4hwtA:
1.1
3ko0O-4hwtA:
1.0
3ko0P-4hwtA:
0.9		 3ko0M-4hwtA:
14.49
3ko0N-4hwtA:
14.49
3ko0O-4hwtA:
14.49
3ko0P-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 10 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.23A 3ko0O-4hwtA:
1.0
3ko0P-4hwtA:
0.9
3ko0Q-4hwtA:
0.2
3ko0R-4hwtA:
1.1		 3ko0O-4hwtA:
14.49
3ko0P-4hwtA:
14.49
3ko0Q-4hwtA:
14.49
3ko0R-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.22A 3ko0Q-4hwtA:
undetectable
3ko0R-4hwtA:
1.1
3ko0S-4hwtA:
1.0
3ko0T-4hwtA:
1.1		 3ko0Q-4hwtA:
14.49
3ko0R-4hwtA:
14.49
3ko0S-4hwtA:
14.49
3ko0T-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 GLY A 570
ARG A 534
GLN A 551
MET A 502
 None
 1.35A 3qx3A-4hwtA:
undetectable		 3qx3A-4hwtA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 GLY A 570
ARG A 534
GLN A 551
MET A 502
 None
 1.48A 3qx3B-4hwtA:
undetectable		 3qx3B-4hwtA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU A 627
ALA A 592
ASP A 494
TYR A 520
 None
 0.85A 3rodD-4hwtA:
undetectable		 3rodD-4hwtA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 MET A 633
LEU A 627
ALA A 592
LEU A 516
ARG A 624
 None
 1.29A 3uudA-4hwtA:
undetectable		 3uudA-4hwtA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ARG A 475
PHE A 491
THR A 593
ARG A 632
 1B2  A 802 (-2.5A)
None
1B2  A 802 ( 4.1A)
None
 0.69A 4k87A-4hwtA:
26.0		 4k87A-4hwtA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ASN A 704
ARG A 724
GLN A 702
LEU A 365
ILE A 385
 None
 1.11A 4kukA-4hwtA:
undetectable		 4kukA-4hwtA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 365
ILE A 385
ASN A 704
GLY A 643
LEU A 637
 None
 1.02A 4lmnA-4hwtA:
undetectable		 4lmnA-4hwtA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PHE A 559
GLU A 564
ASN A 530
ASP A 578
ILE A 577
 None
None
None
1B2  A 802 (-3.7A)
None
 1.14A 4u8yB-4hwtA:
undetectable		 4u8yB-4hwtA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PHE A 559
GLU A 564
ASN A 530
ASP A 578
ILE A 577
 None
None
None
1B2  A 802 (-3.7A)
None
 1.10A 4u95B-4hwtA:
undetectable		 4u95B-4hwtA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 10 MET A 633
LEU A 627
ALA A 592
LEU A 516
ARG A 624
 None
 1.31A 5hyrA-4hwtA:
undetectable		 5hyrA-4hwtA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 PRO A 619
HIS A 497
LEU A 552
PHE A 572
 None
ZN  A 801 ( 3.3A)
None
None
 1.32A 5igjA-4hwtA:
undetectable		 5igjA-4hwtA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 PHE A 523
VAL A 519
ILE A 393
ASP A 494
 None
 1.00A 5iwuA-4hwtA:
undetectable		 5iwuA-4hwtA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 GLN A 599
PHE A 572
CYH A 450
PHE A 499
 None
 1.43A 5mwyA-4hwtA:
undetectable		 5mwyA-4hwtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 GLY A 471
THR A 407
ASN A 445
 None
 0.62A 5odiG-4hwtA:
2.2		 5odiG-4hwtA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 4 ARG A 624
PHE A 515
ASP A 514
LEU A 556
 None
 1.34A 5uhdC-4hwtA:
0.4		 5uhdC-4hwtA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ARG A 517
PHE A 525
PHE A 527
ILE A 626
 None
 1.08A 5vceA-4hwtA:
undetectable		 5vceA-4hwtA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 PRO A 658
GLY A 710
TYR A 666
GLU A 711
 None
 1.14A 6gqiA-4hwtA:
3.1		 6gqiA-4hwtA:
20.96