SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4hx6 OXIDOREDUCTASE
(Streptomyces
globisporus) 		5 / 12 LEU A 130
ALA A  80
ALA A 120
PRO A  41
VAL A  34
 None
 1.08A 1cbrA-4hx6A:
undetectable		 1cbrA-4hx6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4hx6 OXIDOREDUCTASE
(Streptomyces
globisporus) 		5 / 12 LEU A 130
ALA A  80
ALA A 120
PRO A  41
VAL A  34
 None
 1.08A 1cbrB-4hx6A:
undetectable		 1cbrB-4hx6A:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R82_B_ACTB206_0
(OXIDOREDUCTASE)		 4hx6 OXIDOREDUCTASE
(Streptomyces
globisporus) 		4 / 4 LEU A 122
HIS A 129
THR A 154
TRP A 156
 None
 0.17A 4r82B-4hx6A:
28.2		 4r82B-4hx6A:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4hx6 OXIDOREDUCTASE
(Streptomyces
globisporus) 		5 / 12 ALA A  80
GLU A 131
LEU A 130
LEU A 122
LEU A 114
 None
 1.10A 4xi3D-4hx6A:
undetectable		 4xi3D-4hx6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4hx6 OXIDOREDUCTASE
(Streptomyces
globisporus) 		4 / 6 LEU A 122
CYH A 132
HIS A 129
LEU A 130
 None
 1.37A 5hrqD-4hx6A:
undetectable
5hrqG-4hx6A:
undetectable
5hrqH-4hx6A:
undetectable		 5hrqD-4hx6A:
11.11
5hrqG-4hx6A:
7.53
5hrqH-4hx6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4hx6 OXIDOREDUCTASE
(Streptomyces
globisporus) 		5 / 12 SER A 118
VAL A  83
VAL A  59
GLY A 148
ALA A 133
 None
 1.11A 6bqgA-4hx6A:
undetectable		 6bqgA-4hx6A:
19.05