SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hxc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UCB_A_017A201_2 (PROTEASE)	4hxc	PUTATIVE GLYCOSYL HYDROLASE (Bacteroides uniformis)	5 / 12	LEU A 113 GLY A 75 ILE A 271 VAL A 287 VAL A 273	None	1.02A	3ucbB-4hxcA: undetectable	3ucbB-4hxcA: 19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1K_D_LOCD502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	4hxc	PUTATIVE GLYCOSYL HYDROLASE (Bacteroides uniformis)	4 / 4	ASN A 171 SER A 189 ALA A 187 VAL A 168	None	1.40A	4x1kC-4hxcA: undetectable	4x1kC-4hxcA: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D4U_D_SAMD301_0 (UNCHARACTERIZED PROTEIN MJ0489)	4hxc	PUTATIVE GLYCOSYL HYDROLASE (Bacteroides uniformis)	5 / 12	ILE A 285 LEU A 126 GLY A 272 ILE A 138 GLY A 110	None	1.00A	5d4uD-4hxcA: undetectable	5d4uD-4hxcA: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JLC_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	4hxc	PUTATIVE GLYCOSYL HYDROLASE (Bacteroides uniformis)	5 / 12	ALA A 244 PHE A 122 ILE A 271 GLY A 269 THR A 239	None	1.35A	5jlcA-4hxcA: undetectable	5jlcA-4hxcA: 19.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3UCB_A_017A201_2","PROTEASE;PROTEASE","4hxc","PUTATIVE GLYCOSYL HYDROLASE","Bacteroides uniformis",5,"LEU A 113;GLY A  75;ILE A 271;VAL A 287;VAL A 273","None","1.02A","3ucbB-4hxcA:undetectable","3ucbB-4hxcA:19.42"],["4X1K_D_LOCD502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","4hxc","PUTATIVE GLYCOSYL HYDROLASE","Bacteroides uniformis",4,"ASN A 171;SER A 189;ALA A 187;VAL A 168","None","1.40A","4x1kC-4hxcA:undetectable","4x1kC-4hxcA:18.46"],["5D4U_D_SAMD301_0","UNCHARACTERIZED PROTEIN MJ0489","4hxc","PUTATIVE GLYCOSYL HYDROLASE","Bacteroides uniformis",5,"ILE A 285;LEU A 126;GLY A 272;ILE A 138;GLY A 110","None","1.00A","5d4uD-4hxcA:undetectable","5d4uD-4hxcA:20.07"],["5JLC_A_1YNA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","4hxc","PUTATIVE GLYCOSYL HYDROLASE","Bacteroides uniformis",5,"ALA A 244;PHE A 122;ILE A 271;GLY A 269;THR A 239","None","1.35A","5jlcA-4hxcA:undetectable","5jlcA-4hxcA:19.35"]]