SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZN_A_SAMA401_0 (UNCHARACTERIZED PROTEIN MJ0883)	4hxd	RNA-DIRECTED RNA POLYMERASE L (Dugbe orthonairovirus)	5 / 12	TYR B 28 PRO B 21 ASN B 143 ASP B 153 VAL B 147	None	1.15A	2zznA-4hxdB: undetectable	2zznA-4hxdB: 19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_A_PCFA1808_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	4hxd	RNA-DIRECTED RNA POLYMERASE L (Dugbe orthonairovirus)	4 / 5	LEU B 103 ALA B 105 LEU B 108 LEU B 118	None	0.86A	5vkqA-4hxdB: undetectable 5vkqD-4hxdB: undetectable	5vkqA-4hxdB: 7.01 5vkqD-4hxdB: 7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_B_PCFB1805_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	4hxd	RNA-DIRECTED RNA POLYMERASE L (Dugbe orthonairovirus)	4 / 5	LEU B 118 LEU B 103 ALA B 105 LEU B 108	None	0.86A	5vkqA-4hxdB: undetectable 5vkqB-4hxdB: undetectable	5vkqA-4hxdB: 7.01 5vkqB-4hxdB: 7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1806_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	4hxd	RNA-DIRECTED RNA POLYMERASE L (Dugbe orthonairovirus)	4 / 5	LEU B 118 LEU B 103 ALA B 105 LEU B 108	None	0.86A	5vkqB-4hxdB: undetectable 5vkqC-4hxdB: undetectable	5vkqB-4hxdB: 7.01 5vkqC-4hxdB: 7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_D_PCFD1806_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	4hxd	RNA-DIRECTED RNA POLYMERASE L (Dugbe orthonairovirus)	4 / 5	LEU B 118 LEU B 103 ALA B 105 LEU B 108	None	0.88A	5vkqC-4hxdB: undetectable 5vkqD-4hxdB: undetectable	5vkqC-4hxdB: 7.01 5vkqD-4hxdB: 7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X24_A_LSNA502_1 (CYTOCHROME P450 2C9)	4hxd	RNA-DIRECTED RNA POLYMERASE L (Dugbe orthonairovirus)	5 / 12	PHE B 29 VAL B 147 VAL B 121 THR B 19 LEU B 4	None	1.24A	5x24A-4hxdB: undetectable	5x24A-4hxdB: 16.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ZZN_A_SAMA401_0","UNCHARACTERIZED PROTEIN MJ0883","4hxd","RNA-DIRECTED RNA POLYMERASE L","Dugbe orthonairovirus",5,"TYR B  28;PRO B  21;ASN B 143;ASP B 153;VAL B 147","None","1.15A","2zznA-4hxdB:undetectable","2zznA-4hxdB:19.94"],["5VKQ_A_PCFA1808_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","4hxd","RNA-DIRECTED RNA POLYMERASE L","Dugbe orthonairovirus",4,"LEU B 103;ALA B 105;LEU B 108;LEU B 118","None","0.86A","5vkqA-4hxdB:undetectable;5vkqD-4hxdB:undetectable","5vkqA-4hxdB:7.01;5vkqD-4hxdB:7.01"],["5VKQ_B_PCFB1805_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","4hxd","RNA-DIRECTED RNA POLYMERASE L","Dugbe orthonairovirus",4,"LEU B 118;LEU B 103;ALA B 105;LEU B 108","None","0.86A","5vkqA-4hxdB:undetectable;5vkqB-4hxdB:undetectable","5vkqA-4hxdB:7.01;5vkqB-4hxdB:7.01"],["5VKQ_C_PCFC1806_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","4hxd","RNA-DIRECTED RNA POLYMERASE L","Dugbe orthonairovirus",4,"LEU B 118;LEU B 103;ALA B 105;LEU B 108","None","0.86A","5vkqB-4hxdB:undetectable;5vkqC-4hxdB:undetectable","5vkqB-4hxdB:7.01;5vkqC-4hxdB:7.01"],["5VKQ_D_PCFD1806_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","4hxd","RNA-DIRECTED RNA POLYMERASE L","Dugbe orthonairovirus",4,"LEU B 118;LEU B 103;ALA B 105;LEU B 108","None","0.88A","5vkqC-4hxdB:undetectable;5vkqD-4hxdB:undetectable","5vkqC-4hxdB:7.01;5vkqD-4hxdB:7.01"],["5X24_A_LSNA502_1","CYTOCHROME P450 2C9","4hxd","RNA-DIRECTED RNA POLYMERASE L","Dugbe orthonairovirus",5,"PHE B  29;VAL B 147;VAL B 121;THR B  19;LEU B   4","None","1.24A","5x24A-4hxdB:undetectable","5x24A-4hxdB:16.52"]]