SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hxe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ALA B 103
GLY B 122
PHE B 123
LEU B 118
PHE B  78
 None
 1.31A 1brpA-4hxeB:
undetectable		 1brpA-4hxeB:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 6 ASN B 473
VAL B 534
ALA B 531
LEU B 561
 None
 0.81A 1e7bB-4hxeB:
undetectable		 1e7bB-4hxeB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 8 SER B 418
HIS B 385
TYR B 421
PHE B 425
 None
 1.25A 1eqbC-4hxeB:
undetectable
1eqbD-4hxeB:
undetectable		 1eqbC-4hxeB:
21.75
1eqbD-4hxeB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNN_H_ESTH350_1
(MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN
GAMMA-1 CHAIN
MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN KAPPA
CHAIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 10 LYS B   9
ASP B   7
LEU B 402
PHE B  14
TYR B  16
 None
None
None
None
HEZ  B 706 (-3.2A)
 1.49A 1jnnH-4hxeB:
0.0
1jnnL-4hxeB:
0.0		 1jnnH-4hxeB:
15.65
1jnnL-4hxeB:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		6 / 12 ASN B 521
ILE B 512
LEU B 435
GLY B 513
THR B 433
LEU B 525
 None
 1.19A 1liiA-4hxeB:
3.9		 1liiA-4hxeB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 10 GLY B 386
GLY B 387
SER B 466
PHE B 507
HIS B 578
 HEZ  B 709 ( 4.0A)
HEZ  B 709 (-3.7A)
HEZ  B 709 (-2.4A)
HEZ  B 709 (-4.0A)
None
 1.11A 1w76B-4hxeB:
15.7		 1w76B-4hxeB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 TYR B 196
PRO B 138
VAL B 511
ILE B 503
VAL B 240
 None
 1.43A 1z9hA-4hxeB:
undetectable		 1z9hA-4hxeB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 TYR B 196
PRO B 138
VAL B 511
ILE B 503
VAL B 240
 None
 1.44A 1z9hB-4hxeB:
undetectable		 1z9hB-4hxeB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 TYR B 196
PRO B 138
VAL B 511
ILE B 503
VAL B 240
 None
 1.44A 1z9hC-4hxeB:
undetectable		 1z9hC-4hxeB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 LEU B 538
LEU B 476
GLY B 469
ASP B 546
CYH B 549
 None
None
None
None
HEZ  B 709 ( 3.8A)
 1.23A 2bm9B-4hxeB:
undetectable		 2bm9B-4hxeB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 4 SER B 581
GLY B 579
HIS B 385
ASP B 437
 None
 1.38A 2oxtC-4hxeB:
undetectable		 2oxtC-4hxeB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		3 / 3 PRO B 586
ASN B  39
ARG B 587
 None
 0.96A 2qeuB-4hxeB:
undetectable		 2qeuB-4hxeB:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 6 LEU B 325
THR B 336
LEU B  31
ASP B  19
 None
 1.04A 2wm3A-4hxeB:
3.4		 2wm3A-4hxeB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 8 ALA B 267
ILE B 269
ILE B 222
HIS B 179
 None
 1.03A 2zm8A-4hxeB:
undetectable		 2zm8A-4hxeB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 8 ALA B 267
ILE B 269
ILE B 222
HIS B 179
 None
 1.04A 2zmaA-4hxeB:
undetectable		 2zmaA-4hxeB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 SER B 418
ASN B 414
PHE B 383
GLY B 468
ILE B 486
 None
 1.45A 3a25A-4hxeB:
undetectable		 3a25A-4hxeB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 10 ALA B  61
VAL B  30
ILE B 109
ALA B  28
ILE B  45
 None
 0.97A 3ekpC-4hxeB:
undetectable		 3ekpC-4hxeB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 9 ALA B  61
VAL B  30
ILE B 109
ALA B  28
ILE B  45
 None
 0.98A 3ektB-4hxeB:
undetectable		 3ektB-4hxeB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		3 / 3 ARG B  65
ILE B  47
THR B 336
 None
 0.67A 3ia4D-4hxeB:
undetectable		 3ia4D-4hxeB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 473
GLY B 434
PRO B 388
GLY B 386
ASN B 414
 None
None
None
HEZ  B 709 ( 4.0A)
None
 1.11A 3v3oB-4hxeB:
undetectable		 3v3oB-4hxeB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.07A 4e3aA-4hxeB:
undetectable		 4e3aA-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 7 PHE B 596
GLY B 464
ILE B 381
PHE B 600
 None
 0.75A 4ejjA-4hxeB:
undetectable		 4ejjA-4hxeB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		3 / 3 TYR B 338
PHE B  57
ARG B  55
 None
 1.23A 4g19D-4hxeB:
undetectable		 4g19D-4hxeB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 8 ILE B 541
LYS B 603
PHE B 600
GLY B 461
 None
 0.98A 4hdlA-4hxeB:
undetectable		 4hdlA-4hxeB:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 7 ARG B 107
VAL B 187
PHE B 154
GLU B 169
 None
 1.49A 4jseA-4hxeB:
1.6
4jseB-4hxeB:
2.2		 4jseA-4hxeB:
20.98
4jseB-4hxeB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 7 PHE B 154
GLU B 169
ARG B 107
VAL B 187
 None
 1.42A 4jseA-4hxeB:
1.6
4jseB-4hxeB:
2.2		 4jseA-4hxeB:
20.98
4jseB-4hxeB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.08A 4k8tA-4hxeB:
2.6		 4k8tA-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.07A 4k8tB-4hxeB:
2.5		 4k8tB-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.09A 4k93A-4hxeB:
3.0		 4k93A-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.09A 4k93B-4hxeB:
2.8		 4k93B-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.09A 4k9cA-4hxeB:
2.5		 4k9cA-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.07A 4k9iA-4hxeB:
2.2		 4k9iA-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.09A 4k9iB-4hxeB:
2.4		 4k9iB-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.09A 4kadA-4hxeB:
3.2		 4kadA-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 7 SER B  62
GLN B  86
ASN B  43
ASP B  60
 None
 1.26A 4kcnB-4hxeB:
undetectable		 4kcnB-4hxeB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.08A 4lbxA-4hxeB:
3.0		 4lbxA-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.09A 4lbxB-4hxeB:
2.2		 4lbxB-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.09A 4lc4A-4hxeB:
2.2		 4lc4A-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B 521
ILE B 512
GLY B 513
THR B 433
LEU B 525
 None
 1.09A 4lc4B-4hxeB:
2.2		 4lc4B-4hxeB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 8 LEU B 449
VAL B 382
TYR B 409
TYR B 367
 None
 1.12A 4q0bA-4hxeB:
undetectable		 4q0bA-4hxeB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B  39
SER B  38
GLU B  37
ASP B   7
SER B 585
 None
 1.30A 4uroA-4hxeB:
undetectable		 4uroA-4hxeB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B  39
SER B  38
GLU B  37
ASP B   7
SER B 585
 None
 1.35A 4uroB-4hxeB:
undetectable		 4uroB-4hxeB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ASN B  39
SER B  38
GLU B  37
ASP B   7
SER B 585
 None
 1.17A 4uroD-4hxeB:
undetectable		 4uroD-4hxeB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 11 LEU B 230
ASP B 244
ALA B 267
HIS B 243
ASP B 258
 None
MG  B 701 (-3.0A)
None
None
None
 1.36A 4uuuA-4hxeB:
undetectable
4uuuB-4hxeB:
undetectable		 4uuuA-4hxeB:
12.76
4uuuB-4hxeB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 11 LEU B 427
ASP B 437
ALA B 426
ILE B 359
ASP B 360
 HEZ  B 705 ( 4.5A)
None
None
None
None
 1.29A 4uuuA-4hxeB:
undetectable
4uuuB-4hxeB:
undetectable		 4uuuA-4hxeB:
12.76
4uuuB-4hxeB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 11 LEU B 427
ASP B 437
ALA B 426
ILE B 359
ASP B 360
 HEZ  B 705 ( 4.5A)
None
None
None
None
 1.26A 4uuuB-4hxeB:
undetectable		 4uuuB-4hxeB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		3 / 3 ALA B  97
TRP B  88
VAL B  89
 None
 0.28A 4w9nC-4hxeB:
2.4		 4w9nC-4hxeB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 5 ILE B 303
ILE B 296
TYR B 314
GLU B 332
 None
 1.18A 4zzcE-4hxeB:
undetectable		 4zzcE-4hxeB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 5 LYS B 237
ASP B 244
HIS B 243
GLU B 263
 MG  B 701 ( 4.4A)
MG  B 701 (-3.0A)
None
MG  B 701 (-2.6A)
 1.42A 5a06A-4hxeB:
3.6		 5a06A-4hxeB:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 8 TYR B 247
GLY B 233
TYR B 239
PHE B 219
 None
None
HEZ  B 705 (-4.5A)
None
 0.87A 5albL-4hxeB:
undetectable		 5albL-4hxeB:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 6 ASP B 329
TYR B 275
TYR B 314
LEU B 286
 None
 1.37A 5bmvB-4hxeB:
undetectable		 5bmvB-4hxeB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		3 / 3 TYR B 392
TYR B 593
SER B 581
 None
 0.96A 5iktB-4hxeB:
undetectable		 5iktB-4hxeB:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 SER B 283
ASN B 285
ASP B 364
TYR B 394
GLU B 350
 None
 1.15A 5iqbA-4hxeB:
undetectable		 5iqbA-4hxeB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 11 SER B 283
ASN B 285
ASP B 364
TYR B 394
GLU B 350
 None
 1.10A 5iqbC-4hxeB:
0.0		 5iqbC-4hxeB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 SER B 283
ASN B 285
ASP B 364
TYR B 394
GLU B 350
 None
 1.12A 5iqbD-4hxeB:
undetectable		 5iqbD-4hxeB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 SER B 283
ASN B 285
ASP B 364
TYR B 394
GLU B 350
 None
 1.31A 5iqeC-4hxeB:
undetectable		 5iqeC-4hxeB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 SER B 283
ASN B 285
ASP B 364
TYR B 394
GLU B 350
 None
 1.28A 5iqeD-4hxeB:
undetectable		 5iqeD-4hxeB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 VAL B  30
ASP B  19
ALA B  61
THR B  84
ARG B  65
 None
 1.19A 5m5cB-4hxeB:
3.1		 5m5cB-4hxeB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		3 / 3 LYS B 206
TRP B 205
SER B 182
 None
 1.10A 5nwwA-4hxeB:
undetectable		 5nwwA-4hxeB:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 8 SER B  62
GLN B  86
ASN B  43
ASP B  60
 None
 1.26A 5vunA-4hxeB:
undetectable		 5vunA-4hxeB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 8 SER B  62
GLN B  86
ASN B  43
ASP B  60
 None
 1.25A 5vunB-4hxeB:
undetectable		 5vunB-4hxeB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 8 SER B  62
GLN B  86
ASN B  43
ASP B  60
 None
 1.24A 5vuoB-4hxeB:
undetectable		 5vuoB-4hxeB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		4 / 8 SER B  62
GLN B  86
ASN B  43
ASP B  60
 None
 1.18A 6auuB-4hxeB:
undetectable		 6auuB-4hxeB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		3 / 3 GLY B 122
THR B 152
GLU B 150
 None
 0.45A 6b58A-4hxeB:
undetectable		 6b58A-4hxeB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594
(Pyrococcus
horikoshii) 		5 / 12 ILE B 541
SER B 581
ASN B 473
LEU B 538
GLY B 464
 None
 1.12A 6dwnC-4hxeB:
undetectable		 6dwnC-4hxeB:
7.85