SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 4hxi KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 VAL A  96
ILE A  93
ILE A  54
PHE A  75
ILE A  61
 None
 0.97A 1qhsA-4hxiA:
undetectable		 1qhsA-4hxiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4hxi KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 VAL A  96
ILE A  93
ILE A  54
PHE A  75
ILE A  61
 None
 0.92A 1qhyA-4hxiA:
undetectable		 1qhyA-4hxiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4hxi KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 7 PHE A  75
TYR A  74
LEU A 129
THR A 100
 None
 1.05A 2zaxA-4hxiA:
undetectable		 2zaxA-4hxiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 4hxi KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 7 PHE A  75
TYR A  74
LEU A 129
THR A 100
 None
 1.04A 3fwgB-4hxiA:
undetectable		 3fwgB-4hxiA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4hxi KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE A  91
LEU A 130
SER A 102
ILE A 105
LEU A  68
 None
 1.26A 3ia4B-4hxiA:
undetectable		 3ia4B-4hxiA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4hxi KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		3 / 3 LEU A 104
PHE A  75
ILE A 105
 None
 0.74A 5dzk1-4hxiA:
undetectable
5dzkF-4hxiA:
undetectable
5dzkM-4hxiA:
undetectable		 5dzk1-4hxiA:
1.18
5dzkF-4hxiA:
22.49
5dzkM-4hxiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4hxi KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 4 LEU A 104
ARG A  44
ILE A 105
ILE A  61
 None
 1.33A 5dzk2-4hxiA:
undetectable
5dzkM-4hxiA:
undetectable
5dzkN-4hxiA:
undetectable		 5dzk2-4hxiA:
1.18
5dzkM-4hxiA:
21.43
5dzkN-4hxiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4hxi KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 4 ILE A 105
ILE A  61
ARG A  44
LEU A 104
 None
 1.29A 5dzkh-4hxiA:
undetectable
5dzkn-4hxiA:
undetectable
5dzkv-4hxiA:
undetectable		 5dzkh-4hxiA:
21.43
5dzkn-4hxiA:
21.43
5dzkv-4hxiA:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4hxi KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE A  91
LEU A 130
SER A 102
ILE A 105
LEU A  68
 None
 0.99A 5hi6A-4hxiA:
undetectable		 5hi6A-4hxiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4hxi KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE A  93
VAL A  96
LEU A 101
ILE A 105
PHE A  79
 None
 0.98A 5mugA-4hxiA:
undetectable		 5mugA-4hxiA:
22.97