SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.34A 1nncA-4hxtA:
undetectable		 1nncA-4hxtA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		4 / 8 ALA A 120
ALA A 123
ILE A  79
GLU A  77
 None
 0.83A 3dtuC-4hxtA:
undetectable
3dtuD-4hxtA:
undetectable		 3dtuC-4hxtA:
15.87
3dtuD-4hxtA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.32A 3k39A-4hxtA:
undetectable		 3k39A-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.34A 3k39C-4hxtA:
undetectable		 3k39C-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.32A 3k39D-4hxtA:
undetectable		 3k39D-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.33A 3k39E-4hxtA:
undetectable		 3k39E-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.33A 3k39F-4hxtA:
undetectable		 3k39F-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.31A 3k39G-4hxtA:
undetectable		 3k39G-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.33A 3k39H-4hxtA:
undetectable		 3k39H-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.32A 3k39I-4hxtA:
undetectable		 3k39I-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.32A 3k39J-4hxtA:
undetectable		 3k39J-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.33A 3k39K-4hxtA:
undetectable		 3k39K-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.30A 3k39L-4hxtA:
undetectable		 3k39L-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.31A 3k39M-4hxtA:
undetectable		 3k39M-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.33A 3k39N-4hxtA:
undetectable		 3k39N-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.33A 3k39O-4hxtA:
undetectable		 3k39O-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.32A 3k39P-4hxtA:
undetectable		 3k39P-4hxtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		4 / 7 LEU A 220
ILE A 197
VAL A 172
LEU A 175
 None
 0.66A 3r9vA-4hxtA:
undetectable
3r9vB-4hxtA:
undetectable		 3r9vA-4hxtA:
23.38
3r9vB-4hxtA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 VAL A 167
PRO A 201
PRO A 159
VAL A 125
ILE A 121
 None
 1.45A 4eb6B-4hxtA:
undetectable
4eb6C-4hxtA:
undetectable		 4eb6B-4hxtA:
19.96
4eb6C-4hxtA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 108
ARG A  66
GLU A 101
ALA A  27
GLU A  63
 None
 1.37A 4i00A-4hxtA:
undetectable		 4i00A-4hxtA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.19A 4mx0A-4hxtA:
undetectable		 4mx0A-4hxtA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ILE A  71
GLY A  44
ALA A  43
ASP A  42
ILE A  29
 None
 1.07A 6dwnD-4hxtA:
undetectable		 6dwnD-4hxtA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ILE A 155
GLY A 128
ALA A 127
ASP A 126
ILE A 113
 None
 1.05A 6dwnD-4hxtA:
undetectable		 6dwnD-4hxtA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ILE A 197
GLY A 170
ALA A 169
ASP A 168
ILE A 155
 None
 1.06A 6dwnD-4hxtA:
undetectable		 6dwnD-4hxtA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ILE A 239
GLY A 212
ALA A 211
ASP A 210
ILE A 197
 None
 0.99A 6dwnD-4hxtA:
undetectable		 6dwnD-4hxtA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 10 ALA A 149
VAL A 130
ILE A 163
ALA A 162
ALA A 114
 None
 1.10A 6h1lA-4hxtA:
undetectable		 6h1lA-4hxtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 11 ALA A 191
VAL A 172
ILE A 205
ALA A 204
ALA A 156
 None
 1.12A 6h1lB-4hxtA:
undetectable		 6h1lB-4hxtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 4hxt DE NOVO PROTEIN
OR329
(synthetic
construct) 		5 / 12 ARG A 150
ARG A 108
GLU A 143
ALA A  69
GLU A 105
 None
 1.33A 6hcxA-4hxtA:
undetectable		 6hcxA-4hxtA:
16.80