SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hxw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AJ6_A_NOVA1_1
(GYRASE)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 9 ASN A  55
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
ALA A  99
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
None
1A0  A 301 (-3.6A)
 0.49A 1aj6A-4hxwA:
28.8		 1aj6A-4hxwA:
55.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		7 / 12 ASP A  58
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
THR A 174
 None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.60A 1kijA-4hxwA:
28.5		 1kijA-4hxwA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		7 / 12 ASN A  55
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.54A 1kijB-4hxwA:
28.8		 1kijB-4hxwA:
31.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		4 / 8 SER A  67
ASP A  83
GLU A 226
GLU A 215
 None
 1.08A 1knyA-4hxwA:
undetectable
1knyB-4hxwA:
undetectable		 1knyA-4hxwA:
19.01
1knyB-4hxwA:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 12 ASN A  55
SER A  56
ASP A  58
GLU A  59
ASP A  82
ARG A  85
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.51A 1s14A-4hxwA:
25.8		 1s14A-4hxwA:
39.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 12 ASN A  55
SER A  56
ASP A  58
GLU A  59
ASP A  82
ARG A  85
PRO A  88
ALA A  99
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-4.2A)
None
 0.62A 1s14B-4hxwA:
28.1		 1s14B-4hxwA:
39.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		4 / 4 LEU A  48
ALA A 134
VAL A  29
PRO A  33
 None
 1.12A 3gv1B-4hxwA:
undetectable		 3gv1B-4hxwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		5 / 12 ILE A  72
VAL A  80
ILE A  57
VAL A  53
VAL A  49
 None
 1.26A 3iw1A-4hxwA:
undetectable		 3iw1A-4hxwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 12 ASN A  55
SER A  56
ASP A  58
GLU A  59
ASP A  82
ARG A  85
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.48A 3lpsA-4hxwA:
27.9		 3lpsA-4hxwA:
27.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 11 ASN A  55
SER A  56
ASP A  58
GLU A  59
ASP A  82
ARG A  85
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.35A 4urnA-4hxwA:
31.0		 4urnA-4hxwA:
55.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 11 ASN A  55
SER A  56
ASP A  58
GLU A  59
ASP A  82
ARG A  85
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.26A 4urnB-4hxwA:
28.4		 4urnB-4hxwA:
55.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 11 ASN A  55
SER A  56
ASP A  58
GLU A  59
ASP A  82
ARG A  85
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.29A 4urnC-4hxwA:
31.1		 4urnC-4hxwA:
55.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		9 / 12 ASN A  55
SER A  56
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
GLN A  92
SER A 129
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
None
1A0  A 301 (-3.2A)
 0.86A 4uroA-4hxwA:
31.8		 4uroA-4hxwA:
65.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		9 / 12 ASN A  55
SER A  56
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
GLN A  92
SER A 129
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
None
1A0  A 301 (-3.2A)
 0.96A 4uroB-4hxwA:
32.1		 4uroB-4hxwA:
65.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		9 / 12 ASN A  55
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
GLN A  92
ALA A  99
SER A 129
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
None
None
1A0  A 301 (-3.2A)
 0.91A 4uroC-4hxwA:
32.3		 4uroC-4hxwA:
65.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		9 / 12 ASN A  55
SER A  56
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
SER A 129
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.6A)
 0.53A 4uroD-4hxwA:
31.4		 4uroD-4hxwA:
65.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		3 / 3 ARG A 217
ASP A 216
ARG A 218
 None
 0.67A 4wq4B-4hxwA:
undetectable		 4wq4B-4hxwA:
22.71