SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		3 / 3 TRP A 108
ALA A 334
VAL A 107
 None
 0.85A 1c4dC-4hxyA:
undetectable
1c4dD-4hxyA:
undetectable		 1c4dC-4hxyA:
12.84
1c4dD-4hxyA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 GLY A 237
ALA A 238
VAL A 187
ALA A 201
ILE A 213
 None
 0.90A 1rl8A-4hxyA:
undetectable		 1rl8A-4hxyA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 GLY A 106
GLY A 109
GLY A 331
ARG A 168
ASP A 127
 None
 0.99A 2b25A-4hxyA:
5.6		 2b25A-4hxyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 GLY A 191
ARG A 218
ASP A 246
ALA A 274
ALA A 296
 NDP  A 501 (-3.5A)
NDP  A 501 (-3.5A)
NDP  A 501 (-3.6A)
NDP  A 501 (-3.8A)
NDP  A 501 (-3.5A)
 0.76A 2br4F-4hxyA:
6.4		 2br4F-4hxyA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		3 / 3 THR A  79
PRO A  81
PRO A  54
 None
 0.81A 2d55C-4hxyA:
undetectable		 2d55C-4hxyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		4 / 6 ASP A 340
SER A 318
SER A 321
GLY A 322
 None
 0.92A 2j2pA-4hxyA:
undetectable
2j2pC-4hxyA:
undetectable		 2j2pA-4hxyA:
20.63
2j2pC-4hxyA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		4 / 6 ASP A 340
SER A 318
SER A 321
GLY A 322
 None
 0.91A 2j2pD-4hxyA:
undetectable
2j2pF-4hxyA:
undetectable		 2j2pD-4hxyA:
20.63
2j2pF-4hxyA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 GLY A 363
GLY A 197
GLY A 365
ILE A 189
VAL A 200
 None
None
NDP  A 501 (-3.4A)
None
None
 0.79A 2oxtB-4hxyA:
2.1		 2oxtB-4hxyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		4 / 5 LEU A 140
ARG A 137
ALA A 139
ILE A 132
 None
 1.03A 2qhfA-4hxyA:
undetectable		 2qhfA-4hxyA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 10 VAL A 243
MET A 253
ILE A 257
VAL A 267
VAL A 270
 None
 1.26A 3fhjA-4hxyA:
undetectable		 3fhjA-4hxyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 10 VAL A 243
MET A 253
ILE A 257
VAL A 267
VAL A 270
 None
 1.26A 3fhjB-4hxyA:
undetectable		 3fhjB-4hxyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 10 VAL A 243
MET A 253
ILE A 257
VAL A 267
VAL A 270
 None
 1.25A 3fhjC-4hxyA:
undetectable		 3fhjC-4hxyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 9 VAL A 243
MET A 253
ILE A 257
VAL A 267
VAL A 270
 None
 1.26A 3fhjD-4hxyA:
undetectable		 3fhjD-4hxyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 10 VAL A 243
MET A 253
ILE A 257
VAL A 267
VAL A 270
 None
 1.27A 3fhjE-4hxyA:
2.2		 3fhjE-4hxyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 GLY A 331
VAL A  59
GLY A 111
ALA A  63
ALA A  61
 None
 1.11A 3keeB-4hxyA:
undetectable		 3keeB-4hxyA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		6 / 12 THR A  86
ALA A 105
ALA A 100
ALA A 341
ALA A  61
GLY A  62
 None
 1.38A 3mg0Y-4hxyA:
undetectable
3mg0Z-4hxyA:
undetectable		 3mg0Y-4hxyA:
19.13
3mg0Z-4hxyA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		6 / 10 GLY A 335
ALA A 337
ASP A 340
ILE A 323
GLY A 325
VAL A 113
 None
 1.42A 3oxwC-4hxyA:
undetectable		 3oxwC-4hxyA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 GLY A 192
ARG A 346
GLY A 275
ALA A 273
ALA A 301
 None
None
NDP  A 501 (-4.0A)
NDP  A 501 (-3.9A)
None
 1.10A 3sudA-4hxyA:
undetectable		 3sudA-4hxyA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 ARG A 103
GLY A 335
GLY A 106
SER A 321
GLU A 299
 None
 1.19A 3t7sA-4hxyA:
6.3		 3t7sA-4hxyA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 ARG A 103
GLY A 335
GLY A 106
SER A 321
GLU A 299
 None
 1.11A 3t7sB-4hxyA:
6.4		 3t7sB-4hxyA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 ARG A 103
GLY A 335
GLY A 106
SER A 319
GLU A 299
 None
None
None
NDP  A 501 ( 4.0A)
None
 1.44A 3t7sC-4hxyA:
undetectable		 3t7sC-4hxyA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		3 / 3 ARG A 202
GLU A 206
PHE A 236
 None
 0.96A 4kszA-4hxyA:
undetectable		 4kszA-4hxyA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		4 / 8 VAL A 204
VAL A 315
ASP A 313
VAL A 271
 None
 0.56A 4l4bA-4hxyA:
undetectable		 4l4bA-4hxyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 GLY A 115
ALA A 114
GLY A 111
LEU A 110
GLY A 124
 None
 0.93A 4o3fA-4hxyA:
4.1		 4o3fA-4hxyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 GLY A 191
GLY A 194
GLY A 198
THR A 248
ALA A 274
 NDP  A 501 (-3.5A)
NDP  A 501 (-3.4A)
None
NDP  A 501 ( 4.5A)
NDP  A 501 (-3.8A)
 0.89A 4uckA-4hxyA:
undetectable		 4uckA-4hxyA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 GLY A 192
GLY A 194
LEU A 214
ALA A 240
THR A 239
 None
NDP  A 501 (-3.4A)
None
None
None
 0.97A 4uckB-4hxyA:
3.5		 4uckB-4hxyA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 ALA A 283
GLU A 117
GLY A 328
GLY A 111
LEU A  68
 None
 1.04A 4uilH-4hxyA:
undetectable
4uilL-4hxyA:
undetectable		 4uilH-4hxyA:
15.92
4uilL-4hxyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 LEU A  71
ALA A 114
THR A  86
ALA A  61
ALA A  70
 None
 1.27A 4x1iB-4hxyA:
3.4		 4x1iB-4hxyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 ALA A 201
GLY A 191
GLY A 197
GLY A 195
LEU A 216
 None
NDP  A 501 (-3.5A)
None
NDP  A 501 (-3.4A)
None
 0.78A 5c0oH-4hxyA:
6.7		 5c0oH-4hxyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 VAL A  57
GLU A  30
ALA A  69
ALA A  70
VAL A  74
 None
 0.95A 5igjA-4hxyA:
undetectable		 5igjA-4hxyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 MET A 392
ILE A 396
ALA A 274
ALA A 273
GLY A 300
 None
None
NDP  A 501 (-3.8A)
NDP  A 501 (-3.9A)
None
 1.44A 5igpA-4hxyA:
undetectable		 5igpA-4hxyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 PRO A  54
GLU A  30
ALA A  69
ALA A  70
VAL A  74
 None
 0.91A 5igtA-4hxyA:
undetectable		 5igtA-4hxyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 PRO A  54
VAL A  82
ALA A  69
ALA A  70
VAL A  74
 None
 0.92A 5igtA-4hxyA:
undetectable		 5igtA-4hxyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 VAL A  57
GLU A  30
ALA A  69
ALA A  70
VAL A  74
 None
 0.95A 5igtA-4hxyA:
undetectable		 5igtA-4hxyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		4 / 4 GLY A 109
ALA A 330
MET A 294
THR A 285
 None
 1.09A 5n0sB-4hxyA:
undetectable		 5n0sB-4hxyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 12 ALA A 301
LEU A 307
ILE A 257
VAL A 270
ASP A 310
 None
 1.16A 5vlmG-4hxyA:
undetectable		 5vlmG-4hxyA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		4 / 8 VAL A 204
VAL A 315
ASP A 313
VAL A 271
 None
 0.57A 6cp4A-4hxyA:
undetectable		 6cp4A-4hxyA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 10 LEU A  67
LEU A 125
GLN A 157
VAL A  82
CYH A  84
 None
 1.07A 6czmE-4hxyA:
undetectable
6czmF-4hxyA:
undetectable		 6czmE-4hxyA:
23.87
6czmF-4hxyA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 4hxy PLM1
(Streptomyces
sp.
HK803) 		5 / 9 THR A 193
GLY A 194
GLY A 195
HIS A 199
VAL A 385
 NDP  A 501 ( 4.9A)
NDP  A 501 (-3.4A)
NDP  A 501 (-3.4A)
None
None
 1.32A 6gnfA-4hxyA:
5.5		 6gnfA-4hxyA:
21.40