SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 9 ILE A  44
PRO A  62
ALA A  12
ILE A  10
THR A  68
 None
 1.49A 1aj6A-4hy3A:
undetectable		 1aj6A-4hy3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 12 ILE A  21
MET A 312
VAL A 308
LEU A 309
ILE A  36
 None
 0.83A 1epbA-4hy3A:
undetectable		 1epbA-4hy3A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		3 / 3 GLU A 273
HIS A 292
ASP A 247
 None
 0.80A 1i9gA-4hy3A:
6.0		 1i9gA-4hy3A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		4 / 5 ASP A  49
LEU A  52
MET A  72
ARG A  71
 None
 1.45A 2gj5A-4hy3A:
undetectable		 2gj5A-4hy3A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		3 / 3 VAL A 269
ASP A 268
GLU A 273
 None
 0.76A 2qeuA-4hy3A:
undetectable		 2qeuA-4hy3A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		3 / 3 VAL A 269
ASP A 268
GLU A 273
 None
 0.75A 2qeuC-4hy3A:
undetectable		 2qeuC-4hy3A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		4 / 8 ALA A 120
ALA A 239
GLY A 286
ALA A 266
 None
 0.85A 2vh3B-4hy3A:
undetectable		 2vh3B-4hy3A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2001_1
(SERUM ALBUMIN)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 12 LEU A 206
ARG A 181
HIS A 262
ARG A 235
GLY A 237
 None
 1.09A 2vufA-4hy3A:
undetectable		 2vufA-4hy3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2001_1
(SERUM ALBUMIN)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 12 LEU A 206
ILE A 263
HIS A 262
ARG A 235
GLY A 237
 None
 1.13A 2vufA-4hy3A:
undetectable		 2vufA-4hy3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		4 / 5 SER A 267
TYR A 270
PHE A 287
VAL A 258
 None
 1.50A 2x7hB-4hy3A:
8.3		 2x7hB-4hy3A:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		4 / 6 ARG A  27
ILE A  10
LEU A  47
GLU A  14
 None
 1.05A 2ya7A-4hy3A:
undetectable		 2ya7A-4hy3A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		4 / 6 ARG A  27
ILE A  10
LEU A  47
GLU A  14
 None
 1.07A 2ya7B-4hy3A:
undetectable		 2ya7B-4hy3A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		4 / 6 ARG A  27
ILE A  10
LEU A  47
GLU A  14
 None
 1.04A 2ya7D-4hy3A:
undetectable		 2ya7D-4hy3A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		4 / 8 ALA A  45
ILE A  44
ASN A  43
PRO A  62
 None
 0.94A 3fxrA-4hy3A:
undetectable		 3fxrA-4hy3A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		4 / 6 VAL A 101
LEU A 319
MET A 315
ILE A  78
 None
 0.94A 3gcsA-4hy3A:
undetectable		 3gcsA-4hy3A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 10 VAL A 214
PHE A 213
ILE A 288
LEU A 254
VAL A 249
 None
 1.03A 3gwxA-4hy3A:
undetectable		 3gwxA-4hy3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 9 ILE A  78
ILE A  99
ALA A  74
LEU A  75
LEU A  64
 None
 1.05A 3ozvB-4hy3A:
undetectable		 3ozvB-4hy3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 12 SER A 209
PHE A 211
LEU A 173
PHE A 213
GLY A 158
 None
 1.07A 4pevC-4hy3A:
4.0		 4pevC-4hy3A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 12 VAL A  81
ASN A  80
LEU A  85
LEU A  64
ALA A  55
 None
 1.41A 4rtbA-4hy3A:
undetectable		 4rtbA-4hy3A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		4 / 6 ILE A  59
ARG A  27
ILE A  36
GLU A  38
 None
 1.39A 4zzcA-4hy3A:
undetectable
4zzcB-4hy3A:
undetectable		 4zzcA-4hy3A:
22.02
4zzcB-4hy3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		3 / 3 GLU A 273
HIS A 292
ASP A 247
 None
 0.77A 5c0oG-4hy3A:
4.9		 5c0oG-4hy3A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 10 LEU A  18
ILE A  36
PHE A  22
ALA A   9
VAL A 308
 None
 1.22A 5m0oA-4hy3A:
undetectable		 5m0oA-4hy3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 12 ALA A  12
ILE A  36
ARG A  27
LEU A  75
ILE A  44
 None
 1.12A 5m24A-4hy3A:
undetectable		 5m24A-4hy3A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 12 ILE A 241
GLY A 116
VAL A 172
ALA A 120
ALA A 239
 None
 1.00A 5n0oB-4hy3A:
undetectable		 5n0oB-4hy3A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 12 ILE A 241
GLY A 116
VAL A 172
ALA A 120
ALA A 239
 None
 0.99A 5n0tB-4hy3A:
undetectable		 5n0tB-4hy3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 10 LEU A  75
LEU A   8
ILE A  78
PRO A  62
GLY A  60
 None
 0.80A 6dm0B-4hy3A:
2.1
6dm0C-4hy3A:
3.5		 6dm0B-4hy3A:
13.22
6dm0C-4hy3A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE
(Rhizobium
etli) 		5 / 9 ILE A  21
ARG A  27
PRO A  13
VAL A  81
ILE A  59
 None
 1.10A 6ef6A-4hy3A:
undetectable		 6ef6A-4hy3A:
25.45