SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN
(Methanoculleus
marisnigri) 		5 / 12 PHE A 214
ALA A 136
SER A 135
GLY A 219
LEU A 221
 None
 1.13A 1fe2A-4hydA:
undetectable		 1fe2A-4hydA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN
(Methanoculleus
marisnigri) 		5 / 12 PHE A 214
ALA A 136
SER A 135
GLY A 219
LEU A 221
 None
 1.13A 1igxA-4hydA:
undetectable		 1igxA-4hydA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN
(Methanoculleus
marisnigri) 		5 / 12 LEU A  65
LEU A  61
PHE A  57
VAL A 215
ALA A  80
 None
 1.14A 1n5xA-4hydA:
undetectable		 1n5xA-4hydA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN
(Methanoculleus
marisnigri) 		5 / 12 LEU A  65
LEU A  61
PHE A  57
VAL A 215
ALA A  80
 None
 1.14A 1n5xB-4hydA:
undetectable		 1n5xB-4hydA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN
(Methanoculleus
marisnigri) 		4 / 5 LEU A 256
LEU A 259
LEU A  10
LEU A  14
 None
 1.03A 2ab2B-4hydA:
undetectable		 2ab2B-4hydA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN
(Methanoculleus
marisnigri) 		4 / 8 LEU A 292
SER A 231
VAL A 253
GLY A 254
 None
 0.86A 2qd5A-4hydA:
2.6		 2qd5A-4hydA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN
(Methanoculleus
marisnigri) 		4 / 8 LEU A 292
SER A 231
VAL A 253
GLY A 254
 None
 0.84A 2qd5B-4hydA:
2.8		 2qd5B-4hydA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN
(Methanoculleus
marisnigri) 		4 / 4 GLY A 250
VAL A 228
PHE A  18
ILE A  21
 None
 0.91A 4xv2B-4hydA:
undetectable		 4xv2B-4hydA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN
(Methanoculleus
marisnigri) 		5 / 12 ILE A 222
MET A  30
VAL A  27
GLY A  90
PHE A  85
 None
 1.23A 5igiA-4hydA:
undetectable		 5igiA-4hydA:
23.93