SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		5 / 8 LEU A 160
ALA A 118
LEU A 115
LEU A  49
LEU A  92
 None
LFA  A 306 ( 4.2A)
None
None
None
 1.41A 1dvtA-4hyjA:
undetectable
1dvtB-4hyjA:
undetectable		 1dvtA-4hyjA:
21.03
1dvtB-4hyjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		4 / 8 GLY A 143
THR A  79
ILE A 133
SER A 132
 None
 1.05A 2a8tB-4hyjA:
undetectable		 2a8tB-4hyjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		4 / 5 TYR A  83
ILE A 123
ARG A 213
GLY A 197
 None
None
None
LFA  A 308 ( 4.0A)
 1.38A 2du8G-4hyjA:
undetectable		 2du8G-4hyjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		4 / 7 ALA A 118
ASP A 119
GLY A 150
ILE A 149
 LFA  A 306 ( 4.2A)
None
RET  A 301 (-3.7A)
LFA  A 311 ( 4.3A)
 0.83A 2fxdB-4hyjA:
undetectable		 2fxdB-4hyjA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		3 / 3 ARG A  33
VAL A 226
THR A  51
 None
 0.58A 2nmzA-4hyjA:
undetectable		 2nmzA-4hyjA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		4 / 8 ALA A 118
ASP A 119
GLY A 150
ILE A 149
 LFA  A 306 ( 4.2A)
None
RET  A 301 (-3.7A)
LFA  A 311 ( 4.3A)
 0.83A 3el9A-4hyjA:
undetectable		 3el9A-4hyjA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		3 / 3 ARG A  33
VAL A 226
THR A  51
 None
 0.59A 3k4vD-4hyjA:
undetectable		 3k4vD-4hyjA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		3 / 3 ARG A  33
VAL A 226
THR A  51
 None
 0.77A 3ndtA-4hyjA:
undetectable		 3ndtA-4hyjA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		5 / 11 ALA A  64
GLY A  76
LEU A 211
TYR A  58
PHE A  15
 None
 1.24A 3rc0A-4hyjA:
undetectable		 3rc0A-4hyjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		4 / 5 LEU A 111
LEU A 112
LEU A  99
MET A 183
 None
 0.94A 3vhuA-4hyjA:
undetectable		 3vhuA-4hyjA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		5 / 12 ILE A 187
LEU A 161
THR A 163
VAL A 165
LEU A 115
 None
 1.15A 4g1bD-4hyjA:
2.5		 4g1bD-4hyjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRA_C_CPFC401_1
(OUTER MEMBRANE
PROTEIN F)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		5 / 9 ARG A  82
TYR A 217
ARG A 213
TYR A  83
GLY A 143
 None
 1.42A 4kraC-4hyjA:
undetectable		 4kraC-4hyjA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		3 / 3 ASP A 178
LYS A 172
LEU A 101
 None
 1.07A 4ptjA-4hyjA:
undetectable		 4ptjA-4hyjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		5 / 11 LEU A  94
VAL A  95
LEU A 180
GLY A 102
LEU A 111
 None
 1.19A 4zbqA-4hyjA:
2.8		 4zbqA-4hyjA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		5 / 12 TYR A  58
GLY A  18
LEU A  93
PHE A  97
PHE A 228
 None
 1.29A 4ze1A-4hyjA:
undetectable		 4ze1A-4hyjA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		4 / 5 HIS A  57
ILE A  81
PHE A  15
ALA A  64
 None
LFA  A 305 ( 4.5A)
None
None
 1.26A 5msdA-4hyjA:
undetectable		 5msdA-4hyjA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_B_ACTB302_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		4 / 5 GLU A 130
TYR A 198
TYR A  83
ARG A  82
 None
RET  A 301 (-4.3A)
None
None
 1.49A 5mthA-4hyjA:
undetectable
5mthB-4hyjA:
undetectable		 5mthA-4hyjA:
23.05
5mthB-4hyjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_H_ACTH304_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		4 / 5 GLU A 130
TYR A 198
TYR A  83
ARG A  82
 None
RET  A 301 (-4.3A)
None
None
 1.47A 5mthH-4hyjA:
undetectable
5mthL-4hyjA:
undetectable		 5mthH-4hyjA:
23.05
5mthL-4hyjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		3 / 3 LEU A 202
ILE A 133
TYR A  83
 None
 0.70A 5uunB-4hyjA:
undetectable		 5uunB-4hyjA:
23.84