SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		5 / 12 ALA A  96
ASP A  97
ASP A 110
GLY A 122
VAL A   6
 None
 0.86A 1muiB-4hykA:
undetectable		 1muiB-4hykA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		5 / 12 GLY A 165
GLY A 144
ILE A 167
ALA A 146
SER A 159
 None
 1.15A 1ri4A-4hykA:
undetectable		 1ri4A-4hykA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		5 / 12 ALA A  96
ASP A  97
ASP A 110
GLY A 122
VAL A   6
 None
 0.70A 2o4sA-4hykA:
undetectable		 2o4sA-4hykA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		4 / 6 LEU A 151
ASN A 148
LYS A   1
ASP A 110
 None
 1.34A 2w98A-4hykA:
undetectable
2w98B-4hykA:
undetectable		 2w98A-4hykA:
23.12
2w98B-4hykA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		3 / 3 LEU A 250
ARG A 248
ILE A 334
 None
 0.68A 2xn5B-4hykA:
undetectable		 2xn5B-4hykA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		5 / 10 LEU A 109
VAL A 145
ILE A 123
VAL A   6
ILE A   4
 None
 0.98A 3em3B-4hykA:
undetectable		 3em3B-4hykA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A 109
VAL A 145
ILE A 123
VAL A   6
ILE A   4
 None
 0.99A 3em6B-4hykA:
undetectable		 3em6B-4hykA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		5 / 10 LEU A  91
SER A  85
PHE A  84
SER A 103
PHE A  11
 None
 1.42A 3m0wA-4hykA:
undetectable
3m0wB-4hykA:
undetectable
3m0wI-4hykA:
undetectable
3m0wJ-4hykA:
1.5		 3m0wA-4hykA:
15.92
3m0wB-4hykA:
15.92
3m0wI-4hykA:
15.92
3m0wJ-4hykA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		5 / 10 ALA A  96
ASP A  97
ASP A 110
GLY A 122
VAL A   6
 None
 0.86A 3oxwC-4hykA:
undetectable		 3oxwC-4hykA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		6 / 9 ILE A 187
ILE A 184
ALA A 230
LEU A 226
LEU A 195
ALA A 192
 None
 1.46A 3ozvB-4hykA:
undetectable		 3ozvB-4hykA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		4 / 7 PRO A 185
LEU A 176
ASN A 148
ILE A 150
 None
 0.99A 3u5jA-4hykA:
undetectable		 3u5jA-4hykA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		5 / 11 GLY A 144
VAL A 145
GLU A 171
SER A 159
VAL A 143
 None
 1.22A 4d9hA-4hykA:
undetectable		 4d9hA-4hykA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A 109
VAL A 145
ILE A 123
VAL A   6
ILE A   4
 None
 0.92A 4dqbA-4hykA:
undetectable		 4dqbA-4hykA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		4 / 4 LEU A 207
LEU A 226
GLN A 173
GLU A 178
 None
 1.22A 4i41A-4hykA:
undetectable		 4i41A-4hykA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		4 / 7 PHE A  11
ASP A   9
GLN A  14
ILE A 133
 None
 0.98A 4pcuA-4hykA:
undetectable		 4pcuA-4hykA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA305_0
(THAUMATIN-1)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		4 / 5 GLU A 120
ILE A 123
PHE A 119
VAL A 166
 None
 1.29A 4tvtA-4hykA:
undetectable		 4tvtA-4hykA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		4 / 8 LEU A 214
ILE A 187
LEU A 176
ALA A 230
 None
 0.69A 5y7pC-4hykA:
undetectable		 5y7pC-4hykA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 4hyk DNA POLYMERASE IV
(Sulfolobus
acidocaldarius) 		5 / 12 ALA A  96
ASP A  97
ASP A 110
GLY A 122
VAL A   6
 None
 0.79A 6dj1A-4hykA:
undetectable		 6dj1A-4hykA:
13.11