SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		6 / 9 ASN A  41
GLU A  45
ASP A  68
ARG A  71
ILE A  89
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-4.6A)
CJC  A 401 (-3.6A)
 0.49A 1aj6A-4hymA:
27.1		 1aj6A-4hymA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		6 / 9 ASN A  41
GLU A  45
ASP A  68
ARG A  71
PRO A  74
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-3.6A)
 0.79A 1aj6A-4hymA:
27.1		 1aj6A-4hymA:
27.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 ASP A  44
GLU A  45
ASP A  68
ARG A  71
ASP A  76
ILE A  89
ARG A 131
THR A 162
 None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.96A 1kijA-4hymA:
37.0		 1kijA-4hymA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 ASP A  44
GLU A  45
ASP A  68
PRO A  74
ASP A  76
ARG A 131
THR A 162
 None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 1.24A 1kijA-4hymA:
37.0		 1kijA-4hymA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 ASN A  41
GLU A  45
ASP A  68
ARG A  71
ASP A  76
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.76A 1kijB-4hymA:
37.1		 1kijB-4hymA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 ASN A  41
GLU A  45
ASP A  68
PRO A  74
ASP A  76
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 1.04A 1kijB-4hymA:
37.1		 1kijB-4hymA:
37.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 11 LEU A  34
GLY A 114
SER A 116
GLU A  37
LEU A  15
 None
 1.29A 1kyvA-4hymA:
undetectable
1kyvB-4hymA:
undetectable		 1kyvA-4hymA:
18.91
1kyvB-4hymA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		9 / 12 ASN A  41
SER A  42
ASP A  44
GLU A  45
ASP A  68
MET A  73
ASP A  76
ILE A  89
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
None
CJC  A 401 (-4.6A)
CJC  A 401 (-3.6A)
 0.88A 1s14A-4hymA:
27.0		 1s14A-4hymA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		10 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
ASP A  76
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
None
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.61A 1s14A-4hymA:
27.0		 1s14A-4hymA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		10 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
PRO A  74
ASP A  76
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.78A 1s14A-4hymA:
27.0		 1s14A-4hymA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 ASN A  41
SER A  42
ASP A  44
GLU A  45
ASP A  68
MET A  73
ASP A  76
ILE A  89
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
None
CJC  A 401 (-4.6A)
 1.00A 1s14B-4hymA:
29.1		 1s14B-4hymA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		10 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
PRO A  74
ASP A  76
ILE A  89
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
 0.84A 1s14B-4hymA:
29.1		 1s14B-4hymA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 12 LEU A  34
GLY A 114
SER A 116
GLU A  37
LEU A  15
 None
 1.31A 2a58A-4hymA:
undetectable
2a58B-4hymA:
undetectable		 2a58A-4hymA:
18.91
2a58B-4hymA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 12 LEU A  34
GLY A 114
SER A 116
GLU A  37
LEU A  15
 None
 1.30A 2a58B-4hymA:
undetectable
2a58C-4hymA:
undetectable		 2a58B-4hymA:
18.91
2a58C-4hymA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 12 LEU A  34
GLY A 114
SER A 116
GLU A  37
LEU A  15
 None
 1.31A 2a58D-4hymA:
undetectable
2a58E-4hymA:
undetectable		 2a58D-4hymA:
18.91
2a58E-4hymA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 11 ILE A 270
PRO A 271
HIS A  33
GLU A  37
PHE A 328
 None
 1.26A 2aqjA-4hymA:
0.0		 2aqjA-4hymA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 12 VAL A 178
LEU A  58
ILE A  56
ILE A  39
PHE A 166
 None
 1.20A 2gj5A-4hymA:
undetectable		 2gj5A-4hymA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		4 / 5 ILE A 367
PRO A 232
PHE A 252
PHE A 236
 None
 1.04A 2hjhA-4hymA:
undetectable		 2hjhA-4hymA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 12 ILE A 270
PRO A 271
HIS A  33
GLU A  37
PHE A 328
 None
 1.22A 2oa1A-4hymA:
0.4		 2oa1A-4hymA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 12 ILE A 270
PRO A 271
HIS A  33
GLU A  37
PHE A 328
 None
 1.25A 2oa1B-4hymA:
1.1		 2oa1B-4hymA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 12 ILE A  56
LEU A  58
ILE A  39
VAL A 118
VAL A 115
 None
None
None
None
CJC  A 401 (-4.6A)
 1.01A 2ygpA-4hymA:
undetectable		 2ygpA-4hymA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		3 / 3 SER A 265
GLU A 334
ASP A 275
 None
 0.86A 3bwyA-4hymA:
undetectable		 3bwyA-4hymA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		4 / 4 LEU A  34
ALA A 120
VAL A  18
PRO A  22
 None
 1.05A 3gv1B-4hymA:
undetectable		 3gv1B-4hymA:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		9 / 12 ASN A  41
SER A  42
ASP A  44
GLU A  45
ASP A  68
MET A  73
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.70A 3lpsA-4hymA:
41.4		 3lpsA-4hymA:
48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		9 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.40A 3lpsA-4hymA:
41.4		 3lpsA-4hymA:
48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		9 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
PRO A  74
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.55A 3lpsA-4hymA:
41.4		 3lpsA-4hymA:
48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 SER A  42
ASP A  44
GLU A  45
ASP A  68
ASP A  76
ARG A 131
THR A 162
 CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 1.01A 3lpsA-4hymA:
41.4		 3lpsA-4hymA:
48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 SER A  42
GLU A  45
ASP A  68
ARG A  71
PRO A  74
ASP A  76
ARG A 131
THR A 162
 CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 1.03A 3lpsA-4hymA:
41.4		 3lpsA-4hymA:
48.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 12 ILE A  54
ALA A  51
LEU A 197
ALA A 196
ILE A  38
 None
None
None
None
CJC  A 401 (-4.5A)
 0.98A 3oapA-4hymA:
undetectable		 3oapA-4hymA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		4 / 7 PHE A 236
PHE A 252
ALA A 348
LEU A 282
 None
 0.83A 4ejgC-4hymA:
undetectable		 4ejgC-4hymA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		4 / 5 LEU A 231
TRP A 254
ILE A 290
ASN A 297
 None
 1.50A 4i00A-4hymA:
undetectable		 4i00A-4hymA:
23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 11 ASN A  41
SER A  42
ASP A  44
ASP A  68
MET A  73
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.80A 4urnA-4hymA:
27.5		 4urnA-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 11 ASN A  41
SER A  42
ASP A  44
ASP A  68
MET A  73
PRO A  74
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.83A 4urnA-4hymA:
27.5		 4urnA-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		9 / 11 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.66A 4urnA-4hymA:
27.5		 4urnA-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		9 / 11 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
PRO A  74
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.66A 4urnA-4hymA:
27.5		 4urnA-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 11 SER A  42
GLU A  45
ASP A  68
ARG A  71
ILE A  86
 CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
 0.92A 4urnA-4hymA:
27.5		 4urnA-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 11 ASN A  41
SER A  42
ASP A  44
ASP A  68
MET A  73
PRO A  74
ILE A  89
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.6A)
CJC  A 401 (-3.6A)
 0.93A 4urnB-4hymA:
26.2		 4urnB-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		10 / 11 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
PRO A  74
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.65A 4urnB-4hymA:
26.2		 4urnB-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 11 SER A  42
GLU A  45
ASP A  68
ARG A  71
ILE A  86
 CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
 0.88A 4urnB-4hymA:
26.2		 4urnB-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 11 ASN A  41
SER A  42
ASP A  44
ASP A  68
MET A  73
PRO A  74
ILE A  89
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.6A)
CJC  A 401 (-3.6A)
 0.88A 4urnC-4hymA:
27.7		 4urnC-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		10 / 11 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
PRO A  74
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.63A 4urnC-4hymA:
27.7		 4urnC-4hymA:
31.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
ASP A  76
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
CJC  A 401 (-4.2A)
 0.83A 4uroA-4hymA:
27.5		 4uroA-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
ILE A  89
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
 0.50A 4uroA-4hymA:
27.5		 4uroA-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
PRO A  74
ASP A  76
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
 1.05A 4uroA-4hymA:
27.5		 4uroA-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 12 SER A  42
GLU A  45
ASP A  68
ARG A  71
ILE A  86
 CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
 0.83A 4uroA-4hymA:
27.5		 4uroA-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
PRO A  74
ILE A  89
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
 0.68A 4uroB-4hymA:
27.7		 4uroB-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 SER A  42
GLU A  45
ASP A  68
ARG A  71
PRO A  74
ASP A  76
ARG A 131
 CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
 0.99A 4uroB-4hymA:
27.7		 4uroB-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		6 / 12 ASN A  41
GLU A  45
ASP A  68
ARG A  71
ILE A  89
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
 0.52A 4uroC-4hymA:
27.8		 4uroC-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		6 / 12 ASN A  41
GLU A  45
ASP A  68
ARG A  71
PRO A  74
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.2A)
 0.79A 4uroC-4hymA:
27.8		 4uroC-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		6 / 12 GLU A  45
ASP A  68
ARG A  71
PRO A  74
ASP A  76
ARG A 131
 CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
 1.20A 4uroC-4hymA:
27.8		 4uroC-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.50A 4uroD-4hymA:
27.0		 4uroD-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
PRO A  74
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.73A 4uroD-4hymA:
27.0		 4uroD-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 SER A  42
GLU A  45
ASP A  68
ARG A  71
ASP A  76
ARG A 131
THR A 162
 CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.73A 4uroD-4hymA:
27.0		 4uroD-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		4 / 5 GLY A 276
TYR A 266
SER A 265
ASP A 275
 None
 1.21A 4xueA-4hymA:
undetectable		 4xueA-4hymA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		4 / 7 ILE A 319
LEU A 248
GLY A 281
LYS A 283
 None
 0.93A 4z69A-4hymA:
undetectable		 4z69A-4hymA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		4 / 7 ILE A 306
ILE A 286
ILE A 367
LEU A 315
 None
 0.67A 5fukA-4hymA:
undetectable
5fukB-4hymA:
undetectable		 5fukA-4hymA:
20.41
5fukB-4hymA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		4 / 4 THR A  91
LEU A  88
HIS A  94
GLY A  85
 None
 1.49A 5gwyA-4hymA:
undetectable		 5gwyA-4hymA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		3 / 3 GLU A  60
TYR A  59
ARG A 165
 None
 0.78A 5uunA-4hymA:
undetectable		 5uunA-4hymA:
21.92