SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hyn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A  58
ALA A  44
LEU A  96
ILE A 106
LEU A 102
 None
 1.16A 1rx3A-4hynA:
undetectable		 1rx3A-4hynA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		5 / 12 MET A 138
ALA A 141
TYR A  86
GLY A 139
ILE A 155
 None
 1.33A 2dcfA-4hynA:
undetectable		 2dcfA-4hynA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		5 / 10 SER A 144
ILE A  39
ILE A  36
VAL A 186
ILE A  58
 None
 1.05A 2nnhB-4hynA:
undetectable		 2nnhB-4hynA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		5 / 10 MET A 138
ALA A 141
TYR A  86
GLY A 139
ILE A 155
 None
 1.35A 2zm7A-4hynA:
0.0		 2zm7A-4hynA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA512_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		5 / 10 MET A 138
ALA A 141
TYR A  86
GLY A 139
ILE A 155
 None
 1.35A 2zm8A-4hynA:
undetectable		 2zm8A-4hynA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		5 / 8 MET A 138
ALA A 141
TYR A  86
GLY A 139
ILE A 155
 None
 1.35A 2zm9A-4hynA:
undetectable		 2zm9A-4hynA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		5 / 11 MET A 138
ALA A 141
TYR A  86
GLY A 139
ILE A 155
 None
 1.34A 2zmaA-4hynA:
undetectable		 2zmaA-4hynA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		5 / 12 MET A 138
ALA A 141
TYR A  86
GLY A 139
ILE A 155
 None
 1.39A 3a65A-4hynA:
undetectable		 3a65A-4hynA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		5 / 12 VAL A 105
LEU A 109
LEU A 102
SER A  49
GLY A 194
 None
 1.26A 3kk6B-4hynA:
undetectable		 3kk6B-4hynA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		4 / 7 PHE A 188
MET A  41
ILE A  33
VAL A  63
 None
 1.04A 3p6hA-4hynA:
undetectable		 3p6hA-4hynA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		4 / 7 PHE A 188
PHE A 200
ALA A  44
LEU A  96
 None
 0.94A 4ejgA-4hynA:
undetectable		 4ejgA-4hynA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		4 / 8 PHE A 188
PHE A 200
ALA A  44
LEU A  96
 None
 0.86A 4ejgB-4hynA:
undetectable		 4ejgB-4hynA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN
(Thermotoga
maritima) 		5 / 12 GLN A 202
HIS A  57
ASN A  38
GLY A  37
PHE A 200
 None
 1.31A 6exiA-4hynA:
undetectable		 6exiA-4hynA:
20.45