SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 LEU A 232
TYR A  35
GLY A 187
TYR A 228
GLY A 141
 None
 1.19A 1httB-4hyqA:
2.2		 1httB-4hyqA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 THR A  79
TYR A  35
GLY A 187
TYR A 228
GLY A 141
 None
 1.28A 1httB-4hyqA:
2.2		 1httB-4hyqA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 LEU A 232
TYR A  35
GLY A 187
TYR A 228
GLY A 141
 None
 1.22A 1httC-4hyqA:
2.1		 1httC-4hyqA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		4 / 4 ILE A 189
LEU A 140
VAL A 138
ALA A 135
 None
 0.97A 1mz9A-4hyqA:
undetectable		 1mz9A-4hyqA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		4 / 5 ILE A 189
LEU A 140
VAL A 138
ALA A 135
 None
 0.90A 1mz9C-4hyqA:
undetectable		 1mz9C-4hyqA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		4 / 6 ALA A  46
SER A  47
THR A  73
ASN A  70
 None
 0.99A 1yvpB-4hyqA:
undetectable		 1yvpB-4hyqA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 11 GLY A 226
SER A 225
LEU A  38
ILE A 189
ALA A 192
 None
 1.19A 2a58A-4hyqA:
4.6
2a58E-4hyqA:
4.5		 2a58A-4hyqA:
23.46
2a58E-4hyqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 ILE A 189
ALA A 192
GLY A 226
SER A 225
LEU A  38
 None
 1.20A 2a58A-4hyqA:
4.5
2a58B-4hyqA:
4.5		 2a58A-4hyqA:
23.46
2a58B-4hyqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 ILE A 189
ALA A 192
GLY A 226
SER A 225
LEU A  38
 None
 1.21A 2a58B-4hyqA:
4.5
2a58C-4hyqA:
4.7		 2a58B-4hyqA:
23.46
2a58C-4hyqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 11 ILE A 189
ALA A 192
GLY A 226
SER A 225
LEU A  38
 None
 1.19A 2a58C-4hyqA:
4.7
2a58D-4hyqA:
3.0		 2a58C-4hyqA:
23.46
2a58D-4hyqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 ILE A 189
ALA A 192
GLY A 226
SER A 225
LEU A  38
 None
 1.19A 2a58D-4hyqA:
3.0
2a58E-4hyqA:
4.5		 2a58D-4hyqA:
23.46
2a58E-4hyqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 GLY A  86
ASP A  10
SER A  11
ASP A  89
ALA A  88
 None
None
1PE  A 301 ( 4.3A)
None
1PE  A 301 (-4.2A)
 1.10A 2br4C-4hyqA:
2.1		 2br4C-4hyqA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		4 / 7 ALA A  46
SER A  47
THR A  73
ASN A  70
 None
 1.06A 2i91A-4hyqA:
4.2		 2i91A-4hyqA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		4 / 7 ALA A  46
SER A  47
THR A  73
ASN A  70
 None
 1.06A 2i91B-4hyqA:
3.6		 2i91B-4hyqA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 GLY A 187
VAL A 231
SER A  13
ASN A 172
PRO A 143
 None
 1.18A 2okcB-4hyqA:
undetectable		 2okcB-4hyqA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 9 PHE A  48
LEU A 229
LEU A 140
ALA A  34
ALA A   7
 None
 1.14A 2vcvD-4hyqA:
undetectable		 2vcvD-4hyqA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 9 PHE A  48
LEU A 229
LEU A 140
ALA A  34
ALA A   7
 None
 1.14A 2vcvE-4hyqA:
undetectable		 2vcvE-4hyqA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		4 / 8 ILE A 189
PRO A 143
PRO A  36
GLY A 226
 None
 0.70A 3em0B-4hyqA:
undetectable		 3em0B-4hyqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 GLY A   9
SER A  13
ASP A  10
ASP A  84
LEU A  78
 None
 1.19A 3iv6B-4hyqA:
3.3		 3iv6B-4hyqA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		4 / 8 ASP A  49
GLY A   9
ILE A  80
VAL A 137
 None
 0.75A 3nu9A-4hyqA:
undetectable		 3nu9A-4hyqA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		4 / 5 LEU A 171
GLY A  81
THR A  58
VAL A 124
 None
 1.04A 3wrkD-4hyqA:
undetectable		 3wrkD-4hyqA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 ILE A  80
THR A  58
GLY A 119
ILE A 175
VAL A 174
 None
 0.96A 4c9lA-4hyqA:
undetectable		 4c9lA-4hyqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 ILE A  80
THR A  58
GLY A 119
ILE A 175
VAL A 174
 None
 0.96A 4c9lB-4hyqA:
undetectable		 4c9lB-4hyqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 ILE A  80
THR A  58
GLY A 119
ILE A 175
VAL A 174
 None
 0.96A 4c9oA-4hyqA:
undetectable		 4c9oA-4hyqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 ILE A  80
THR A  58
GLY A 119
ILE A 175
VAL A 174
 None
 0.96A 4c9oB-4hyqA:
undetectable		 4c9oB-4hyqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		4 / 7 SER A  13
TYR A  35
TYR A  12
PRO A 219
 None
None
1PE  A 301 (-4.8A)
None
 0.76A 5aclA-4hyqA:
undetectable		 5aclA-4hyqA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 LEU A 232
TYR A  35
GLY A 187
TYR A 228
GLY A 141
 None
 1.21A 5e3iA-4hyqA:
undetectable		 5e3iA-4hyqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 11 THR A  79
TYR A  35
GLY A 187
TYR A 228
GLY A 141
 None
 1.32A 5e3iB-4hyqA:
undetectable		 5e3iB-4hyqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		4 / 6 LEU A 205
TYR A  35
ASP A  10
GLN A  65
 None
 1.50A 6djzC-4hyqA:
undetectable		 6djzC-4hyqA:
19.22