SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		3 / 3 THR A 110
ASP A  93
SER A  89
 None
 0.85A 2nxeA-4hyrA:
undetectable		 2nxeA-4hyrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		4 / 9 ALA A 181
VAL A 184
CYH A 188
LYS A 189
 None
 0.97A 2vufB-4hyrA:
undetectable		 2vufB-4hyrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		5 / 11 ALA A 360
LEU A 361
PHE A 197
ILE A 386
GLY A 385
 None
 1.27A 3bpxA-4hyrA:
undetectable
3bpxB-4hyrA:
undetectable		 3bpxA-4hyrA:
15.59
3bpxB-4hyrA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_1
(GLUCOCORTICOID
RECEPTOR)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		5 / 12 MET A 213
LEU A 230
CYH A 255
THR A 282
PHE A 274
 None
 1.49A 3cldB-4hyrA:
undetectable		 3cldB-4hyrA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		5 / 12 VAL A 184
CYH A 188
ALA A 190
ALA A 191
LEU A 173
 None
 0.90A 3fc6C-4hyrA:
undetectable		 3fc6C-4hyrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		6 / 11 VAL A 321
ILE A 305
ALA A 308
ALA A 288
ALA A 283
THR A 284
 None
 1.29A 3mdtB-4hyrA:
undetectable		 3mdtB-4hyrA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		3 / 3 TYR A 358
ASP A 199
ASP A 225
 None
 0.79A 3ou6B-4hyrA:
undetectable		 3ou6B-4hyrA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		3 / 3 HIS A 335
SER A 343
ASN A 338
 None
 0.88A 3s8pB-4hyrA:
undetectable		 3s8pB-4hyrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		3 / 3 LYS A 221
LYS A 220
PRO A 224
 None
 1.00A 4dv1L-4hyrA:
undetectable		 4dv1L-4hyrA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		5 / 12 GLY A 204
HIS A 335
LEU A 144
MET A 219
HIS A 364
 None
None
None
None
CL  A 502 (-4.4A)
 1.36A 4emaA-4hyrA:
undetectable		 4emaA-4hyrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		4 / 6 GLY A 370
ASN A 175
GLU A 163
GLN A 402
 None
 1.25A 4g0vB-4hyrA:
undetectable		 4g0vB-4hyrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		4 / 8 ASP A 240
ASP A 434
ARG A 442
GLU A 262
 None
 1.11A 4gkhF-4hyrA:
undetectable		 4gkhF-4hyrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		4 / 8 HIS A 311
PRO A 310
ASP A 309
SER A 334
 None
 1.00A 4k0bB-4hyrA:
undetectable		 4k0bB-4hyrA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		4 / 8 HIS A 311
PRO A 310
ASP A 309
SER A 334
 None
 0.96A 4l7iB-4hyrA:
undetectable		 4l7iB-4hyrA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		4 / 6 LEU A 202
LEU A 187
VAL A 184
PHE A 148
 None
None
None
CL  A 502 ( 4.9A)
 1.16A 4uswA-4hyrA:
undetectable		 4uswA-4hyrA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		4 / 6 LEU A 187
LEU A 202
ILE A 179
PHE A 149
 None
 0.76A 4y4dA-4hyrA:
undetectable		 4y4dA-4hyrA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		4 / 6 SER A 336
ASP A 199
ARG A 142
GLY A 385
 None
 1.02A 5cdqA-4hyrA:
undetectable
5cdqC-4hyrA:
undetectable
5cdqD-4hyrA:
undetectable		 5cdqA-4hyrA:
22.39
5cdqC-4hyrA:
22.39
5cdqD-4hyrA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		3 / 3 HIS A 335
SER A 343
ASN A 338
 None
 0.92A 5cprB-4hyrA:
undetectable		 5cprB-4hyrA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		3 / 3 TRP A 236
GLU A 212
ASP A 231
 None
 0.55A 5gqbA-4hyrA:
6.4		 5gqbA-4hyrA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		5 / 12 VAL A  67
VAL A  63
LEU A 109
ILE A 342
MET A 346
 None
 1.24A 5hv1A-4hyrA:
undetectable		 5hv1A-4hyrA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		4 / 7 HIS A  27
ASP A 231
GLY A 204
ASN A  22
 CL  A 502 (-4.2A)
None
None
None
 1.14A 5x7pA-4hyrA:
undetectable		 5x7pA-4hyrA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		4 / 5 HIS A  27
ASP A 231
GLY A 204
ASN A  22
 CL  A 502 (-4.2A)
None
None
None
 1.13A 5x7pB-4hyrA:
undetectable		 5x7pB-4hyrA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		4 / 5 LEU A 374
THR A  32
PRO A 159
ARG A 153
 None
 0.99A 6ew0F-4hyrA:
undetectable		 6ew0F-4hyrA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		4 / 6 LEU A 374
THR A  32
PRO A 159
ARG A 153
 None
 0.99A 6ew0G-4hyrA:
undetectable		 6ew0G-4hyrA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		5 / 12 VAL A  50
ASP A 257
ASP A 309
HIS A 335
GLY A 105
 None
 1.46A 6gnfA-4hyrA:
undetectable		 6gnfA-4hyrA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 4hyr GLUCARATE
DEHYDRATASE
(Acidaminococcus
intestini) 		5 / 12 VAL A  50
ASP A 257
ASP A 309
HIS A 335
GLY A 105
 None
 1.47A 6gnfC-4hyrA:
undetectable		 6gnfC-4hyrA:
22.43