SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hyv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		4 / 4 LEU A 266
VAL A 261
CYH A 295
ALA A 320
 None
 1.15A 1mz9E-4hyvA:
undetectable		 1mz9E-4hyvA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		4 / 6 PRO A  30
HIS A  55
ASP A 197
TYR A  60
 None
 1.26A 2lh8A-4hyvA:
undetectable		 2lh8A-4hyvA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		5 / 9 ASP A 207
GLY A 258
ILE A 259
VAL A 223
ILE A 209
 None
 1.12A 3ekvB-4hyvA:
undetectable		 3ekvB-4hyvA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		5 / 12 ILE A  81
VAL A 206
LEU A  83
ILE A 259
ILE A 214
 None
 0.99A 3mb5A-4hyvA:
3.7		 3mb5A-4hyvA:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		10 / 10 THR A  27
PRO A  30
ARG A  50
ASN A  52
HIS A  55
GLY A  56
TYR A  60
GLY A 332
ALA A 335
LYS A 336
 None
None
PEP  A1003 (-3.8A)
K  A1002 (-3.3A)
None
None
None
None
None
None
 0.48A 3pp7B-4hyvA:
67.4		 3pp7B-4hyvA:
74.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		4 / 7 GLU A 455
VAL A 458
LEU A 398
GLN A 492
 None
 1.05A 3qeoB-4hyvA:
undetectable		 3qeoB-4hyvA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		5 / 11 SER A 284
ILE A 283
VAL A 293
VAL A 261
ILE A 253
 None
 1.19A 3rf4A-4hyvA:
undetectable
3rf4C-4hyvA:
undetectable		 3rf4A-4hyvA:
13.56
3rf4C-4hyvA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		5 / 11 ILE A 253
SER A 284
ILE A 283
VAL A 293
VAL A 261
 None
 1.21A 3rf4A-4hyvA:
undetectable
3rf4B-4hyvA:
undetectable		 3rf4A-4hyvA:
13.56
3rf4B-4hyvA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		5 / 11 ILE A 253
SER A 284
ILE A 283
VAL A 293
VAL A 261
 None
 1.23A 3rf4B-4hyvA:
undetectable
3rf4C-4hyvA:
undetectable		 3rf4B-4hyvA:
13.56
3rf4C-4hyvA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		5 / 12 LEU A 180
LEU A 151
CYH A 164
ILE A 178
PHE A 102
 None
 1.21A 4a79B-4hyvA:
undetectable		 4a79B-4hyvA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		4 / 6 THR A 112
ARG A 175
ILE A 178
LEU A 162
 None
 1.21A 4ac9C-4hyvA:
3.3		 4ac9C-4hyvA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		4 / 6 THR A 112
ARG A 175
ILE A 178
LEU A 162
 None
 1.25A 4acaC-4hyvA:
3.9		 4acaC-4hyvA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		6 / 12 LEU A 198
ILE A 209
ASN A  52
ASP A  84
GLY A  87
GLY A 264
 None
None
K  A1002 (-3.3A)
K  A1002 (-3.4A)
None
PEP  A1003 (-3.3A)
 1.35A 4an2A-4hyvA:
undetectable		 4an2A-4hyvA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		5 / 11 GLY A 258
GLN A 431
MET A 208
PHE A 210
ILE A 294
 None
 1.46A 4j4vA-4hyvA:
undetectable		 4j4vA-4hyvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		5 / 10 ASP A 207
GLY A 258
ILE A 259
VAL A 223
ILE A 209
 None
 1.11A 4q1wB-4hyvA:
undetectable		 4q1wB-4hyvA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		5 / 12 GLU A 222
ILE A 214
ILE A 252
SER A 256
ARG A 215
 None
 1.30A 4uroB-4hyvA:
undetectable		 4uroB-4hyvA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		5 / 12 ALA A 296
SER A 302
THR A 310
GLU A 333
SER A 331
 PEP  A1003 ( 3.9A)
None
None
None
PEP  A1003 ( 4.9A)
 1.20A 5hfjE-4hyvA:
undetectable		 5hfjE-4hyvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		3 / 3 ALA A  37
ASN A  40
LEU A  41
 None
 0.42A 5i1oC-4hyvA:
undetectable		 5i1oC-4hyvA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		3 / 3 VAL A 108
HIS A 170
VAL A 144
 None
 0.51A 5jmnC-4hyvA:
undetectable		 5jmnC-4hyvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		4 / 5 LEU A 460
CYH A 429
LEU A 426
ASP A 444
 None
 1.34A 5mafA-4hyvA:
undetectable		 5mafA-4hyvA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		4 / 4 GLY A  80
ALA A  49
MET A  42
THR A  64
 None
 1.21A 5n0sB-4hyvA:
undetectable		 5n0sB-4hyvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4hyv PYRUVATE KINASE 1
(Trypanosoma
brucei) 		5 / 12 ARG A 221
GLY A 231
ILE A 214
ALA A 189
GLY A 228
 None
 0.90A 5veuH-4hyvA:
undetectable		 5veuH-4hyvA:
22.42