SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hyy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 11 MET A 270
PHE A 125
ILE A 312
ALA A 313
ALA A 124
 None
 1.35A 1jb0B-4hyyA:
undetectable		 1jb0B-4hyyA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 5 ILE A 121
ILE A 156
ILE A 256
LEU A 135
 None
 0.87A 1zgyA-4hyyA:
undetectable		 1zgyA-4hyyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 10 VAL A 264
PHE A 265
LEU A 203
VAL A 206
LEU A 253
 None
 0.95A 3gwxA-4hyyA:
undetectable		 3gwxA-4hyyA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 11 MET A 270
PHE A 125
ILE A 312
ALA A 313
ALA A 124
 None
 1.34A 3pcqB-4hyyA:
undetectable		 3pcqB-4hyyA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 5 LEU A 135
GLY A 131
PHE A 328
PHE A 108
 None
 0.82A 3smtA-4hyyA:
undetectable		 3smtA-4hyyA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 7 GLY A 290
GLY A 289
MET A 226
ASN A 268
 None
 1.07A 4fgkB-4hyyA:
undetectable		 4fgkB-4hyyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 5 GLY A 290
GLY A 289
MET A 226
ASN A 268
 None
 1.05A 4fglC-4hyyA:
undetectable		 4fglC-4hyyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		3 / 3 SER A 136
ASP A 223
GLN A 269
 None
 0.95A 4oltA-4hyyA:
undetectable
4oltB-4hyyA:
undetectable		 4oltA-4hyyA:
23.45
4oltB-4hyyA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 10 LEU A 253
VAL A 266
GLU A 123
THR A 298
VAL A 264
 None
 1.25A 4yb6B-4hyyA:
undetectable
4yb6F-4hyyA:
undetectable		 4yb6B-4hyyA:
21.18
4yb6F-4hyyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 7 THR A 138
LEU A 139
LEU A 135
THR A 142
 None
 0.91A 4z90A-4hyyA:
undetectable
4z90B-4hyyA:
undetectable
4z90C-4hyyA:
undetectable
4z90D-4hyyA:
undetectable
4z90E-4hyyA:
undetectable		 4z90A-4hyyA:
18.83
4z90B-4hyyA:
18.83
4z90C-4hyyA:
18.83
4z90D-4hyyA:
18.83
4z90E-4hyyA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 12 MET A 270
PHE A 125
ILE A 312
ALA A 313
ALA A 124
 None
 1.24A 5oy02-4hyyA:
undetectable		 5oy02-4hyyA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 10 MET A 270
PHE A 125
ILE A 312
ALA A 313
ALA A 124
 None
 1.28A 5oy0b-4hyyA:
undetectable		 5oy0b-4hyyA:
18.36