SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4hz2 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Xanthobacter
autotrophicus) 		3 / 3 ALA A 144
VAL A 181
TRP A 184
 None
 1.02A 1tkqA-4hz2A:
undetectable		 1tkqA-4hz2A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 4hz2 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Xanthobacter
autotrophicus) 		5 / 9 LEU A 175
LEU A 136
HIS A 101
ALA A 129
ALA A 171
 None
 1.28A 2bxcB-4hz2A:
undetectable		 2bxcB-4hz2A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4hz2 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Xanthobacter
autotrophicus) 		5 / 12 ALA A 180
PRO A 179
VAL A 181
PHE A  96
ASP A 137
 None
 1.24A 2v95A-4hz2A:
undetectable		 2v95A-4hz2A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 4hz2 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Xanthobacter
autotrophicus) 		4 / 5 ALA A 163
GLU A 102
GLU A  97
ALA A 106
 None
UNL  A 303 ( 4.9A)
None
UNL  A 303 ( 4.1A)
 1.34A 3r9tC-4hz2A:
undetectable		 3r9tC-4hz2A:
24.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HZ2_A_BEZA302_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4hz2 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Xanthobacter
autotrophicus) 		6 / 6 MET A   6
SER A   9
ARG A 109
TYR A 110
TRP A 114
TYR A 164
 GSH  A 301 (-3.6A)
BEZ  A 302 (-3.1A)
BEZ  A 302 ( 4.3A)
UNL  A 303 ( 4.0A)
BEZ  A 302 (-3.5A)
BEZ  A 302 (-4.4A)
 0.01A 4hz2A-4hz2A:
39.1		 4hz2A-4hz2A:
100.00