SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		3 / 3 ASP A  60
ASP A  77
ASP A  62
 None
 0.76A 1eizA-4hz4A:
undetectable		 1eizA-4hz4A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		3 / 3 ASP A  60
ASP A  77
ASP A  62
 None
 0.75A 1ej0A-4hz4A:
undetectable		 1ej0A-4hz4A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		4 / 8 PHE A 137
ILE A 181
THR A 182
LEU A 170
 None
 0.81A 1hmyA-4hz4A:
undetectable		 1hmyA-4hz4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		4 / 5 ALA A  93
TYR A  97
ALA A  88
TYR A  94
 None
 1.13A 1xl6A-4hz4A:
undetectable
1xl6B-4hz4A:
undetectable		 1xl6A-4hz4A:
23.32
1xl6B-4hz4A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		5 / 12 SER A 163
VAL A  18
ALA A 197
TYR A 194
LEU A 207
 None
 1.25A 2japB-4hz4A:
undetectable		 2japB-4hz4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		5 / 12 SER A 163
VAL A  18
ALA A 197
TYR A 194
LEU A 207
 None
 1.26A 2japD-4hz4A:
undetectable		 2japD-4hz4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		4 / 4 ALA A  93
TYR A  97
ALA A  88
TYR A  94
 None
 1.13A 2wlkA-4hz4A:
undetectable
2wlkB-4hz4A:
undetectable		 2wlkA-4hz4A:
23.32
2wlkB-4hz4A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		4 / 7 ALA A 193
ALA A 197
THR A 201
LEU A  30
 None
 0.66A 2wx2A-4hz4A:
undetectable		 2wx2A-4hz4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		4 / 8 ALA A 193
ALA A 197
THR A 201
LEU A  30
 None
 0.70A 2wx2B-4hz4A:
undetectable		 2wx2B-4hz4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		4 / 5 ILE A 188
SER A 163
PHE A 164
PRO A 165
 None
 1.42A 3bjwC-4hz4A:
undetectable		 3bjwC-4hz4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		4 / 8 ALA A 193
ALA A 197
THR A 201
LEU A  30
 None
 0.67A 3khmA-4hz4A:
undetectable		 3khmA-4hz4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		4 / 8 ALA A 193
ALA A 197
THR A 201
LEU A  30
 None
 0.72A 3l4dA-4hz4A:
undetectable		 3l4dA-4hz4A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		4 / 8 ALA A 193
ALA A 197
THR A 201
LEU A  30
 None
 0.67A 3l4dD-4hz4A:
undetectable		 3l4dD-4hz4A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		3 / 3 ASN A  69
ALA A 161
ARG A  16
 None
 0.87A 3tj7C-4hz4A:
undetectable
3tj7D-4hz4A:
undetectable		 3tj7C-4hz4A:
22.98
3tj7D-4hz4A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		5 / 12 ALA A 114
GLY A 134
ILE A 181
THR A 182
GLY A 169
 None
 1.16A 4n48B-4hz4A:
undetectable		 4n48B-4hz4A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4hz4 GLUTATHIONE-S-TRANSF
ERASE
(Actinobacillus
pleuropneumoniae) 		4 / 6 LEU A   6
ILE A   4
LEU A  21
GLU A  22
 None
 0.91A 4w5nA-4hz4A:
undetectable		 4w5nA-4hz4A:
13.24