SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hzc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4hzc CYSE, SERINE
ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 12 PRO A 111
GLN A  96
LEU A  51
ILE A  19
SER A  22
 None
 1.37A 2fj1A-4hzcA:
undetectable		 2fj1A-4hzcA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4hzc CYSE, SERINE
ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 11 LEU A  51
LEU A  91
ILE A  23
THR A 123
VAL A  98
 None
 1.24A 2qd3A-4hzcA:
undetectable		 2qd3A-4hzcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4hzc CYSE, SERINE
ACETYLTRANSFERASE
(Brucella
abortus) 		4 / 6 LEU A 126
PHE A  77
ILE A  59
ALA A  60
 None
 1.10A 3mdrA-4hzcA:
undetectable		 3mdrA-4hzcA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4hzc CYSE, SERINE
ACETYLTRANSFERASE
(Brucella
abortus) 		4 / 6 LEU A 192
ALA A 169
THR A 152
LEU A 164
 None
 0.87A 3t3zA-4hzcA:
undetectable		 3t3zA-4hzcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4hzc CYSE, SERINE
ACETYLTRANSFERASE
(Brucella
abortus) 		4 / 6 LEU A 192
ALA A 169
THR A 152
LEU A 164
 None
 0.86A 3t3zB-4hzcA:
undetectable		 3t3zB-4hzcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4hzc CYSE, SERINE
ACETYLTRANSFERASE
(Brucella
abortus) 		4 / 6 LEU A 192
ALA A 169
THR A 152
LEU A 164
 None
 0.83A 3t3zD-4hzcA:
undetectable		 3t3zD-4hzcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4hzc CYSE, SERINE
ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 10 LEU A  51
LEU A  91
ILE A  23
THR A 123
VAL A  98
 None
 1.26A 4mk4A-4hzcA:
undetectable		 4mk4A-4hzcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4hzc CYSE, SERINE
ACETYLTRANSFERASE
(Brucella
abortus) 		3 / 3 ASP A  78
LEU A  81
PHE A  77
 None
 0.75A 4pthA-4hzcA:
undetectable		 4pthA-4hzcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4hzc CYSE, SERINE
ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 12 VAL A 240
SER A 234
VAL A 210
LEU A 211
GLY A 213
 None
 1.08A 4y8wB-4hzcA:
undetectable		 4y8wB-4hzcA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4hzc CYSE, SERINE
ACETYLTRANSFERASE
(Brucella
abortus) 		4 / 6 ARG A 125
ASP A 182
GLY A 163
ASP A  94
 None
 1.28A 5hp1A-4hzcA:
undetectable		 5hp1A-4hzcA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4hzc CYSE, SERINE
ACETYLTRANSFERASE
(Brucella
abortus) 		4 / 6 PRO A 204
VAL A 180
VAL A 184
ILE A 218
 None
 0.83A 5pbeA-4hzcA:
undetectable		 5pbeA-4hzcA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4hzc CYSE, SERINE
ACETYLTRANSFERASE
(Brucella
abortus) 		4 / 4 HIS A 124
VAL A 180
LEU A 160
ALA A 158
 None
 1.33A 6d8pB-4hzcA:
undetectable		 6d8pB-4hzcA:
15.99