SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 8 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.39A 1ceaA-4hzhA:
undetectable
1ceaB-4hzhA:
undetectable		 1ceaA-4hzhA:
10.67
1ceaB-4hzhA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 7 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.40A 1ceaB-4hzhA:
undetectable		 1ceaB-4hzhA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 7 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.61A 1cebA-4hzhA:
undetectable		 1cebA-4hzhA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 7 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.36A 1cebB-4hzhA:
undetectable		 1cebB-4hzhA:
10.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		6 / 12 HIS A 363
TYR A 367
TRP A 370
LEU A 416
VAL A 545
GLY A 558
 None
 0.93A 1etrH-4hzhA:
29.8		 1etrH-4hzhA:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		6 / 12 HIS A 363
TYR A 367
TRP A 370
VAL A 545
GLY A 548
GLY A 558
 None
 1.29A 1etrH-4hzhA:
29.8		 1etrH-4hzhA:
86.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 5 GLU A 250
ARG A 418
ASP A 417
THR A 186
 None
 1.31A 1k4tA-4hzhA:
undetectable		 1k4tA-4hzhA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 8 GLU A 309
LYS A 532
GLU A 305
GLU A 300
 None
 1.11A 1knyA-4hzhA:
undetectable
1knyB-4hzhA:
undetectable		 1knyA-4hzhA:
18.96
1knyB-4hzhA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4hzh PROTHROMBIN
(Homo
sapiens) 		5 / 12 GLU A 328
GLY A 324
ILE A 395
GLY A 330
ILE A 329
 None
 1.05A 1q8jB-4hzhA:
undetectable		 1q8jB-4hzhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 5 GLU A 226
ARG A 418
ASP A 417
THR A 186
 None
 1.31A 1rr8C-4hzhA:
undetectable		 1rr8C-4hzhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 5 GLU A 250
ARG A 418
ASP A 417
THR A 186
 None
 1.21A 1rr8C-4hzhA:
undetectable		 1rr8C-4hzhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 5 GLU A 226
ARG A 418
ASP A 417
THR A 186
 None
 1.31A 1rrjA-4hzhA:
undetectable		 1rrjA-4hzhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 5 GLU A 250
ARG A 418
ASP A 417
THR A 186
 None
 1.22A 1rrjA-4hzhA:
undetectable		 1rrjA-4hzhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 4hzh PROTHROMBIN
(Homo
sapiens) 		5 / 12 GLY A 558
GLY A 548
GLY A 550
ALA A 520
ASN A 415
 None
 1.10A 2dpmA-4hzhA:
undetectable		 2dpmA-4hzhA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_B_H4BB1001_1
(HYPOTHETICAL PROTEIN
PH0634)		 4hzh PROTHROMBIN
(Homo
sapiens) 		5 / 10 ILE A 501
ASP A 503
GLU A 227
HIS A 407
THR A 561
 None
 1.32A 2dttA-4hzhA:
undetectable
2dttB-4hzhA:
undetectable		 2dttA-4hzhA:
13.38
2dttB-4hzhA:
13.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		5 / 11 HIS A 407
ARG A 409
TRP A 569
VAL A 573
GLU A 579
 None
 1.35A 2h9tH-4hzhA:
29.1		 2h9tH-4hzhA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		6 / 11 HIS A 407
PRO A 408
TRP A 569
LYS A 572
VAL A 573
GLU A 579
 None
 1.09A 2h9tH-4hzhA:
29.1		 2h9tH-4hzhA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 8 VAL A 212
ASP A 173
GLY A 224
TYR A 247
 None
 1.04A 3af0A-4hzhA:
undetectable		 3af0A-4hzhA:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		7 / 11 HIS A 407
ARG A 418
TRP A 569
LYS A 572
VAL A 573
GLN A 576
GLU A 579
 None
 1.47A 3bf6H-4hzhA:
29.5		 3bf6H-4hzhA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		8 / 11 HIS A 407
PRO A 408
ARG A 409
ARG A 418
TRP A 569
LYS A 572
VAL A 573
GLU A 579
 None
 1.24A 3bf6H-4hzhA:
29.5		 3bf6H-4hzhA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVV_A_CPFA1081_1
(APOLIPOPROTEIN(A))		 4hzh PROTHROMBIN
(Homo
sapiens) 		5 / 9 ASP A 223
ASP A 225
TRP A 230
TYR A 232
PHE A 240
 None
 0.77A 4bvvA-4hzhA:
undetectable		 4bvvA-4hzhA:
12.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		6 / 12 HIS A 363
TYR A 367
TRP A 370
LYS A 372
LEU A 416
GLY A 558
 None
 0.96A 4hfpB-4hzhA:
29.5		 4hfpB-4hzhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		6 / 12 HIS A 363
TYR A 367
LEU A 416
ILE A 499
VAL A 545
GLY A 558
 None
 0.86A 4hfpD-4hzhA:
29.9		 4hfpD-4hzhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		7 / 12 HIS A 363
TYR A 367
TRP A 370
LEU A 416
ALA A 525
VAL A 545
GLY A 558
 None
 0.79A 4hfpD-4hzhA:
29.9		 4hfpD-4hzhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		5 / 12 GLY A 349
GLN A 335
ALA A 350
VAL A 358
SER A 332
 None
 1.21A 4pd9A-4hzhA:
undetectable		 4pd9A-4hzhA:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		7 / 12 HIS A 363
TYR A 367
TRP A 370
ALA A 525
VAL A 545
GLY A 548
GLY A 558
 None
 1.04A 4rn6B-4hzhA:
36.9		 4rn6B-4hzhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4hzh PROTHROMBIN
(Homo
sapiens) 		7 / 12 HIS A 363
TYR A 367
TRP A 370
LEU A 416
ALA A 525
VAL A 545
GLY A 558
 None
 0.73A 4rn6B-4hzhA:
36.9		 4rn6B-4hzhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4hzh PROTHROMBIN
(Homo
sapiens) 		3 / 3 SER A 275
GLU A 305
GLU A 314
 None
 0.82A 4ymgB-4hzhA:
undetectable		 4ymgB-4hzhA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 6 THR A 186
THR A 185
VAL A 184
HIS A 187
 None
 0.93A 5ecoA-4hzhA:
undetectable		 5ecoA-4hzhA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4hzh PROTHROMBIN
(Homo
sapiens) 		4 / 7 VAL A 530
VAL A 563
PRO A 441
TYR A 540
 None
 0.98A 5x80C-4hzhA:
undetectable
5x80D-4hzhA:
undetectable		 5x80C-4hzhA:
16.98
5x80D-4hzhA:
16.98