SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4hzi ABC TRANSPORTER
ATP-BINDING PROTEIN
(Leptospira
interrogans) 		5 / 12 ILE A 202
ILE A 168
LEU A  48
LEU A   7
ILE A  63
 None
 1.08A 1bsxA-4hziA:
undetectable		 1bsxA-4hziA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4hzi ABC TRANSPORTER
ATP-BINDING PROTEIN
(Leptospira
interrogans) 		5 / 12 ILE A 202
ILE A 168
LEU A  48
LEU A   7
ILE A  63
 None
 1.08A 1bsxB-4hziA:
undetectable		 1bsxB-4hziA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4hzi ABC TRANSPORTER
ATP-BINDING PROTEIN
(Leptospira
interrogans) 		3 / 3 LEU A  85
MET A 169
MET A  55
 None
 0.91A 2vavF-4hziA:
undetectable		 2vavF-4hziA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4hzi ABC TRANSPORTER
ATP-BINDING PROTEIN
(Leptospira
interrogans) 		5 / 12 ALA A 216
ILE A  82
LEU A  48
LEU A  51
GLY A  54
 None
 1.22A 4l9qB-4hziA:
undetectable		 4l9qB-4hziA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4hzi ABC TRANSPORTER
ATP-BINDING PROTEIN
(Leptospira
interrogans) 		5 / 12 ILE A 154
LEU A 105
VAL A 161
THR A 126
LEU A  85
 None
 1.05A 5byjA-4hziA:
undetectable		 5byjA-4hziA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4hzi ABC TRANSPORTER
ATP-BINDING PROTEIN
(Leptospira
interrogans) 		5 / 12 TYR A 191
PHE A 197
ILE A 154
PHE A 187
TYR A  53
 None
 1.28A 6mkeA-4hziA:
undetectable
6mkeD-4hziA:
undetectable		 6mkeA-4hziA:
16.49
6mkeD-4hziA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4hzi ABC TRANSPORTER
ATP-BINDING PROTEIN
(Leptospira
interrogans) 		5 / 12 TYR A 191
PHE A 197
ILE A 154
PHE A 187
TYR A  53
 None
 1.30A 6mkeB-4hziA:
undetectable
6mkeC-4hziA:
undetectable		 6mkeB-4hziA:
16.49
6mkeC-4hziA:
16.49