SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hzp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 THR A 280
PRO A 283
THR A 282
 None
 0.94A 1dscC-4hzpA:
undetectable		 1dscC-4hzpA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 TRP A  37
ALA A  16
VAL A  89
 None
 0.89A 1kqeA-4hzpA:
undetectable
1kqeE-4hzpA:
undetectable		 1kqeA-4hzpA:
3.57
1kqeE-4hzpA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		4 / 8 ARG A 243
ALA A 247
GLU A 286
LEU A 235
 None
 0.92A 2bxgA-4hzpA:
undetectable		 2bxgA-4hzpA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 LEU A  34
GLY A  35
PHE A 124
CYH A  93
VAL A  50
 None
 1.38A 2w8yA-4hzpA:
undetectable		 2w8yA-4hzpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 ARG A 129
GLU A 123
SER A  80
 None
 0.80A 2xctD-4hzpA:
undetectable		 2xctD-4hzpA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		4 / 5 LEU A  34
GLY A  35
PHE A 227
ASN A 139
 None
 1.09A 3uq6B-4hzpA:
undetectable		 3uq6B-4hzpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 PRO A 167
LEU A 166
GLN A  96
 None
 0.63A 4pevB-4hzpA:
undetectable		 4pevB-4hzpA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 ASP A 255
ARG A  69
PRO A 128
GLU A  75
GLY A  73
 None
SO4  A 404 (-3.0A)
None
None
None
 1.17A 5il1A-4hzpA:
undetectable		 5il1A-4hzpA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 ASP A 255
ARG A  69
PRO A 128
GLU A  75
GLY A  73
 None
SO4  A 404 (-3.0A)
None
None
None
 1.18A 5k7uA-4hzpA:
undetectable		 5k7uA-4hzpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		4 / 5 GLN A  96
VAL A 101
PRO A 175
THR A  41
 None
 1.37A 6cduA-4hzpA:
undetectable
6cduB-4hzpA:
undetectable		 6cduA-4hzpA:
21.81
6cduB-4hzpA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		4 / 5 GLN A  96
VAL A 101
PRO A 175
THR A  41
 None
 1.45A 6cduI-4hzpA:
undetectable
6cduJ-4hzpA:
undetectable		 6cduI-4hzpA:
21.81
6cduJ-4hzpA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		4 / 6 ASP A 255
GLN A 309
VAL A 254
ALA A 190
 None
 1.22A 6djzB-4hzpA:
undetectable		 6djzB-4hzpA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE
(Streptomyces
atroolivaceus) 		5 / 10 GLY A 219
LEU A 220
TYR A 226
SER A  28
PHE A 223
 None
None
COA  A 401 ( 4.8A)
None
CL  A 402 (-4.9A)
 1.35A 6gnfC-4hzpA:
undetectable		 6gnfC-4hzpA:
21.71