SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hzu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.27A 1a52A-4hzuT:
undetectable
1a52A-4hzuT:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.32A 1a52B-4hzuT:
undetectable
1a52B-4hzuT:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
5 / 11 THR B 198
LEU B  28
VAL B  30
VAL B  87
VAL B 166
None
1.10A 1akdA-4hzuB:
undetectable
1akdA-4hzuB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis)
5 / 12 PHE T  50
GLY T  53
SER T  58
LEU T  27
LEU T 126
None
1.26A 1fm6X-4hzuT:
undetectable
1fm6X-4hzuT:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_B_ESTB600_1
(OESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 9 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.39A 1gwrB-4hzuT:
undetectable
1gwrB-4hzuT:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
5 / 9 THR B 198
LEU B  28
VAL B  30
VAL B  87
VAL B 166
None
1.07A 1iwjA-4hzuB:
undetectable
1iwjA-4hzuB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
5 / 9 THR B 198
LEU B  28
VAL B  30
VAL B 168
VAL B 166
None
1.49A 1iwjA-4hzuB:
undetectable
1iwjA-4hzuB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
4 / 8 LEU S 110
VAL S 144
GLY S 145
LEU S 114
None
0.84A 1jlbA-4hzuS:
undetectable
1jlbA-4hzuS:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
4 / 7 GLU A 221
LEU A 218
LEU A  36
GLU A  34
None
0.84A 1linA-4hzuA:
undetectable
1linA-4hzuA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
5 / 10 THR B 198
LEU B  28
VAL B  30
VAL B  87
VAL B 166
None
1.06A 1o76A-4hzuB:
undetectable
1o76A-4hzuB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)
4hzu PREDICTED MEMBRANE
PROTEIN
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis)
5 / 12 LEU T 171
GLY S  60
GLY S  64
LEU T 219
THR S  10
None
1.03A 1p91B-4hzuT:
undetectable
1p91B-4hzuT:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.32A 1pcgA-4hzuT:
undetectable
1pcgA-4hzuT:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.29A 1pcgB-4hzuT:
undetectable
1pcgB-4hzuT:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
4 / 8 LEU S 110
VAL S 144
GLY S 145
LEU S 114
None
0.84A 1s1xA-4hzuS:
undetectable
1s1xA-4hzuS:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
5 / 11 VAL B 200
ILE B  50
LEU B  53
LEU B  28
MET B 219
None
1.25A 2a15A-4hzuB:
undetectable
2a15A-4hzuB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
5 / 11 THR B 198
LEU B  28
VAL B  30
VAL B  87
VAL B 166
None
0.98A 2a1nA-4hzuB:
undetectable
2a1nA-4hzuB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1
ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
4 / 7 GLY B 175
GLU A 166
SER A 169
HIS A 199
None
1.13A 2ackA-4hzuB:
2.7
2ackA-4hzuB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
5 / 10 THR B 198
LEU B  28
VAL B  30
VAL B  87
VAL B 166
None
1.07A 2cp4A-4hzuB:
undetectable
2cp4A-4hzuB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
4 / 7 THR B 198
LEU B  28
VAL B  30
VAL B  87
None
1.03A 2cppA-4hzuB:
undetectable
2cppA-4hzuB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 TYR S  45
ILE S  49
ALA S  48
PRO S 157
ILE S 154
None
1.35A 2dm6A-4hzuS:
undetectable
2dm6B-4hzuS:
undetectable
2dm6A-4hzuS:
21.65
2dm6B-4hzuS:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)
4hzu PREDICTED MEMBRANE
PROTEIN
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis)
5 / 12 LEU T 165
ALA S  17
ARG T 166
SER S  63
ALA T 137
None
1.11A 2ejtA-4hzuT:
undetectable
2ejtA-4hzuT:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
4 / 5 VAL S  20
THR S  19
VAL S  59
GLY S  60
None
1.01A 2p2fA-4hzuS:
undetectable
2p2fA-4hzuS:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
4 / 4 VAL S  20
THR S  19
VAL S  59
GLY S  60
None
0.99A 2p2fB-4hzuS:
undetectable
2p2fB-4hzuS:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
5 / 12 LEU B 187
PHE B 188
LEU B 191
PRO B 164
VAL B 159
None
1.14A 2po5A-4hzuB:
undetectable
2po5A-4hzuB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2
PREDICTED MEMBRANE
PROTEIN
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis;
Lactobacillus
brevis)
5 / 12 PHE T 213
LEU S 161
PRO S 163
ASN A  92
ASP A 165
None
1.44A 2zznB-4hzuT:
undetectable
2zznB-4hzuT:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
4 / 6 GLY A 175
ILE A 177
GLU A 178
ASP A 172
None
0.90A 3a7eA-4hzuA:
undetectable
3a7eA-4hzuA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.32A 3erdB-4hzuT:
undetectable
3erdB-4hzuT:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2
ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis;
Lactobacillus
brevis)
3 / 3 GLU A 236
ASP A 214
ASP B 177
None
0.76A 3jb2A-4hzuA:
undetectable
3jb2A-4hzuA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
5 / 9 GLU A  34
VAL A  30
ILE A 163
LEU A  53
ILE A 161
None
1.30A 3jw3B-4hzuA:
2.6
3jw3B-4hzuA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.49A 3p97A-4hzuA:
undetectable
3p97A-4hzuA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.47A 3p97C-4hzuA:
undetectable
3p97C-4hzuA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 12 GLN S 143
THR S 124
GLY S 133
ALA S 135
GLY S 139
None
0.97A 3tegA-4hzuS:
undetectable
3tegA-4hzuS:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
4 / 7 PRO B  59
LEU B  80
LEU B  83
ILE B  64
None
0.82A 3u5jA-4hzuB:
undetectable
3u5jA-4hzuB:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
4 / 7 PRO B  59
LEU B  80
LEU B  83
ILE B  64
None
0.86A 3u5kB-4hzuB:
undetectable
3u5kB-4hzuB:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
4 / 8 PRO B  59
LEU B  80
LEU B  83
ILE B  64
None
0.93A 3u5kC-4hzuB:
undetectable
3u5kC-4hzuB:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
4 / 8 PRO B  59
LEU B  80
LEU B  83
ILE B  64
None
0.91A 3u5kD-4hzuB:
undetectable
3u5kD-4hzuB:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.30A 3uudB-4hzuT:
undetectable
3uudB-4hzuT:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1
ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
5 / 12 ALA B 250
ALA B 271
LEU A 247
ALA B 254
ILE A 201
None
1.23A 3uvvB-4hzuB:
undetectable
3uvvB-4hzuB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis)
5 / 12 PHE B 144
LEU T 204
ILE T 178
ALA T 212
SER T 211
None
1.25A 4a83A-4hzuB:
undetectable
4a83A-4hzuB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.49A 4ctjA-4hzuA:
undetectable
4ctjA-4hzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.46A 4ctkA-4hzuA:
undetectable
4ctkA-4hzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
5 / 9 THR B 198
LEU B  28
VAL B  30
VAL B  87
VAL B 166
None
1.13A 4ek1B-4hzuB:
undetectable
4ek1B-4hzuB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
4 / 4 LEU B 169
PRO B 172
LEU B 201
ILE B 199
None
0.95A 4f4dB-4hzuB:
undetectable
4f4dB-4hzuB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1
ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
4 / 6 GLY B 175
ASN A  42
GLN A 147
MET A 179
None
1.28A 4g0vB-4hzuB:
undetectable
4g0vB-4hzuB:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1
ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis)
4 / 8 ASP A  91
ARG T 215
GLU B 171
GLU B  95
None
1.04A 4gkhF-4hzuA:
undetectable
4gkhF-4hzuA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 12 LEU T 171
MET T 205
LEU T 208
ILE S  44
LEU S  39
None
1.08A 4j24A-4hzuT:
undetectable
4j24A-4hzuT:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 12 LEU T 171
MET T 205
LEU T 208
ILE S  44
LEU S  39
None
1.07A 4j24B-4hzuT:
undetectable
4j24B-4hzuT:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 12 LEU T 171
MET T 205
LEU T 208
ILE S  44
LEU S  39
None
1.08A 4j24C-4hzuT:
undetectable
4j24C-4hzuT:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 12 LEU T 171
MET T 205
LEU T 208
ILE S  44
LEU S  39
None
1.08A 4j26B-4hzuT:
undetectable
4j26B-4hzuT:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
3 / 3 ILE A 154
MET A 179
ARG A 148
None
0.95A 4lnwA-4hzuA:
undetectable
4lnwA-4hzuA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1
ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
4 / 8 ASP A 240
GLU B 207
GLN B 205
THR A 168
None
1.04A 4lnwA-4hzuA:
undetectable
4lnwA-4hzuA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
3 / 3 ILE A 154
MET A 179
ARG A 148
None
0.95A 4lnxA-4hzuA:
undetectable
4lnxA-4hzuA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1
ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
4 / 8 ALA S  17
ASN B  96
ILE T 178
SER A 139
None
0.81A 4r20A-4hzuS:
0.3
4r20A-4hzuS:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
4 / 5 LEU B 201
VAL B  30
VAL B  87
TYR B  35
None
1.12A 4r7iA-4hzuB:
undetectable
4r7iA-4hzuB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
3 / 3 VAL S  91
TYR S  45
ALA S  48
None
0.47A 4ybnA-4hzuS:
undetectable
4ybnA-4hzuS:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1
ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
4 / 5 ALA B 213
TYR B 212
HIS A 199
PRO B 172
None
1.17A 4ze2A-4hzuB:
undetectable
4ze2A-4hzuB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 11 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.26A 4zn7B-4hzuT:
undetectable
4zn7B-4hzuT:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
GLY S  43
None
1.28A 5dx3A-4hzuT:
undetectable
5dx3A-4hzuT:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.30A 5dx3A-4hzuT:
undetectable
5dx3A-4hzuT:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_B_ESTB1000_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 9 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.34A 5dx3B-4hzuT:
undetectable
5dx3B-4hzuT:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
GLY S  43
None
1.32A 5dxbA-4hzuT:
undetectable
5dxbA-4hzuT:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.32A 5dxbA-4hzuT:
undetectable
5dxbA-4hzuT:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.35A 5dxeB-4hzuT:
undetectable
5dxeB-4hzuT:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.46A 5e9qC-4hzuA:
undetectable
5e9qC-4hzuA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.48A 5ec8C-4hzuA:
undetectable
5ec8C-4hzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
4 / 5 THR B  21
ALA B  22
THR B  11
HIS B  20
None
1.24A 5ecmA-4hzuB:
undetectable
5ecmA-4hzuB:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.45A 5ehgA-4hzuA:
undetectable
5ehgA-4hzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.48A 5eifA-4hzuA:
undetectable
5eifA-4hzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.45A 5eifC-4hzuA:
undetectable
5eifC-4hzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.44A 5eiwC-4hzuA:
undetectable
5eiwC-4hzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 12 GLY S  61
VAL S 150
GLY S  88
THR S  86
LEU S  81
None
1.06A 5hg0B-4hzuS:
undetectable
5hg0B-4hzuS:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.30A 5hyrA-4hzuT:
undetectable
5hyrA-4hzuT:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 11 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.35A 5hyrB-4hzuT:
undetectable
5hyrB-4hzuT:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.48A 5ikmA-4hzuA:
undetectable
5ikmA-4hzuA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.45A 5kqsA-4hzuA:
undetectable
5kqsA-4hzuA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
4hzu PREDICTED MEMBRANE
PROTEIN
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis)
5 / 12 LEU T 161
ALA S  62
SER S  80
PHE S  65
LEU S  39
None
1.35A 5ljbA-4hzuT:
undetectable
5ljbA-4hzuT:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
5 / 12 LEU A  49
ILE A  83
VAL A  64
LEU A  71
VAL A  79
None
1.04A 5mugA-4hzuA:
undetectable
5mugA-4hzuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.48A 5njvB-4hzuA:
undetectable
5njvB-4hzuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
4 / 6 ARG B 152
ARG B 153
ALA B 155
PRO B  94
None
1.34A 5odqA-4hzuB:
undetectable
5odqA-4hzuB:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 12 LEU T 171
GLU T 174
MET T 205
LEU T 208
LEU S  39
None
1.09A 5toaB-4hzuT:
undetectable
5toaB-4hzuT:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGD_A_ESTA601_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 9 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.36A 5wgdA-4hzuT:
undetectable
5wgdA-4hzuT:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 9 ALA T 175
GLU T 174
LEU T 208
ARG T 215
GLY S  43
None
1.36A 5wgqA-4hzuT:
undetectable
5wgqA-4hzuT:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 9 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.29A 5wgqA-4hzuT:
undetectable
5wgqA-4hzuT:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.27A 5wgqB-4hzuT:
undetectable
5wgqB-4hzuT:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis)
6 / 12 GLY A 216
THR A  24
ASP A   9
VAL A  26
ASP A 214
ILE A 213
None
1.48A 5wz2B-4hzuA:
undetectable
5wz2B-4hzuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis)
4 / 8 PRO B  59
LEU B  80
LEU B  83
ILE B  64
None
0.87A 5y1yA-4hzuB:
undetectable
5y1yA-4hzuB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis)
5 / 10 ALA T 137
PRO T 169
SER A 139
PHE A  94
ARG T 166
None
1.34A 6b89B-4hzuT:
undetectable
6b89B-4hzuT:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis)
5 / 10 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
None
1.33A 6cbzB-4hzuT:
2.1
6cbzB-4hzuT:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis)
4 / 6 GLU T 174
ARG T 215
PHE T 167
VAL T 168
None
1.47A 6fgdA-4hzuT:
undetectable
6fgdA-4hzuT:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0G_B_Y70B502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)
4hzu PREDICTED MEMBRANE
PROTEIN
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis)
5 / 11 HIS S  84
GLU S  41
PHE T 209
GLN S  87
GLY S  88
None
1.50A 6h0gB-4hzuS:
undetectable
6h0gC-4hzuS:
undetectable
6h0gB-4hzuS:
14.79
6h0gC-4hzuS:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis)
5 / 10 SER A 132
MET A 130
GLY A  96
ALA T 222
VAL A 103
None
1.47A 6hu9L-4hzuA:
undetectable
6hu9P-4hzuA:
undetectable
6hu9T-4hzuA:
undetectable
6hu9L-4hzuA:
22.48
6hu9P-4hzuA:
21.13
6hu9T-4hzuA:
15.38