SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		5 / 12 MET A 257
LEU A  93
ASN A  92
LEU A  74
ILE A 180
 None
 1.24A 1p93A-4i0nA:
undetectable		 1p93A-4i0nA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		4 / 5 LEU A  91
GLY A  76
ILE A 311
PHE A 309
 None
 0.87A 1xf1A-4i0nA:
undetectable		 1xf1A-4i0nA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		4 / 6 LEU A  91
GLY A  76
ILE A 311
PHE A 309
 None
 0.90A 1xf1B-4i0nA:
3.0		 1xf1B-4i0nA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		4 / 8 HIS A  83
PRO A  82
ASP A  81
SER A 154
 None
 1.20A 2obvA-4i0nA:
undetectable		 2obvA-4i0nA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		4 / 5 SER A  99
GLY A 251
ASP A 210
ASP A 242
 None
None
None
MG  A 403 ( 3.9A)
 1.14A 2oxtB-4i0nA:
undetectable		 2oxtB-4i0nA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		5 / 12 ILE A 142
THR A 189
ILE A 137
ILE A 180
SER A 181
 None
 1.28A 3kpbC-4i0nA:
undetectable		 3kpbC-4i0nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		5 / 10 ILE A 142
THR A 189
ILE A 137
ILE A 180
SER A 181
 None
 1.30A 3kpbD-4i0nA:
undetectable		 3kpbD-4i0nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		5 / 9 PHE A 205
PHE A 187
PHE A 226
ILE A 249
THR A 240
 None
 1.30A 3t3rB-4i0nA:
undetectable		 3t3rB-4i0nA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		5 / 10 PHE A 205
PHE A 187
PHE A 226
ILE A 249
THR A 240
 None
 1.31A 3t3rD-4i0nA:
undetectable		 3t3rD-4i0nA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		4 / 5 ALA A 196
ILE A 131
LEU A 261
ASN A 197
 None
None
None
MG  A 405 ( 4.8A)
 1.23A 4g19A-4i0nA:
undetectable		 4g19A-4i0nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		4 / 5 PRO A  82
ASP A  81
ILE A  48
VAL A 176
 None
 1.42A 4hytA-4i0nA:
undetectable		 4hytA-4i0nA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		4 / 8 HIS A  83
PRO A  82
ASP A  81
SER A 154
 None
 1.15A 4kttA-4i0nA:
undetectable		 4kttA-4i0nA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		4 / 8 HIS A  83
PRO A  82
ASP A  81
SER A 154
 None
 1.16A 4kttC-4i0nA:
undetectable		 4kttC-4i0nA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		3 / 3 LYS A 113
ASN A 223
ASP A 280
 None
 0.86A 4o1eA-4i0nA:
undetectable		 4o1eA-4i0nA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		4 / 4 LYS A 113
ASN A 223
ASP A 215
ASP A 280
 None
 1.06A 4o1eB-4i0nA:
undetectable		 4o1eB-4i0nA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		4 / 8 HIS A  83
PRO A  82
ASP A  81
SER A 154
 None
 1.20A 5t8sB-4i0nA:
undetectable		 5t8sB-4i0nA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		4 / 8 HIS A  83
PRO A  82
ASP A  81
SER A 154
 None
 1.16A 6fcbA-4i0nA:
undetectable		 6fcbA-4i0nA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4i0n NECROTIC ENTERITIS
TOXIN B
(Clostridium
perfringens) 		4 / 8 HIS A  83
PRO A  82
ASP A  81
SER A 154
 None
 1.18A 6fcdA-4i0nA:
undetectable		 6fcdA-4i0nA:
15.98