SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DM BETA
CHAIN
HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO ALPHA
CHAIN

(Homo
sapiens)
5 / 11 ASP B  31
GLY C  58
GLY C  59
PHE C  32
HIS C  24
None
1.14A 1w76A-4i0pB:
undetectable
1w76A-4i0pB:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO ALPHA
CHAIN
HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO BETA
CHAIN

(Homo
sapiens;
Homo
sapiens)
4 / 7 ARG D  29
ALA C   3
ASP D  14
TYR D  16
None
1.01A 2e5dA-4i0pD:
undetectable
2e5dB-4i0pD:
undetectable
2e5dA-4i0pD:
14.89
2e5dB-4i0pD:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO ALPHA
CHAIN
HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO BETA
CHAIN

(Homo
sapiens;
Homo
sapiens)
4 / 7 ASP D  14
TYR D  16
ARG D  29
ALA C   3
None
1.02A 2e5dA-4i0pD:
undetectable
2e5dB-4i0pD:
undetectable
2e5dA-4i0pD:
14.89
2e5dB-4i0pD:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO ALPHA
CHAIN
HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO BETA
CHAIN

(Homo
sapiens;
Homo
sapiens)
4 / 8 SER C 139
GLN D  10
ILE D  31
SER C   8
None
0.92A 2xz5B-4i0pC:
undetectable
2xz5E-4i0pC:
3.5
2xz5B-4i0pC:
23.01
2xz5E-4i0pC:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO ALPHA
CHAIN
HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO BETA
CHAIN

(Homo
sapiens)
4 / 7 VAL C  91
ILE D 148
GLN D 156
GLY D 146
None
0.91A 3bjwH-4i0pC:
undetectable
3bjwH-4i0pC:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO BETA
CHAIN

(Homo
sapiens)
5 / 9 ASP D 126
GLY D 125
PHE D 122
VAL D 159
THR D 157
None
1.39A 4acaB-4i0pD:
undetectable
4acaC-4i0pD:
undetectable
4acaB-4i0pD:
17.44
4acaC-4i0pD:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DM BETA
CHAIN

(Homo
sapiens)
4 / 8 PHE B 122
HIS B 178
GLU B 177
ILE B 129
None
1.19A 4cx7A-4i0pB:
undetectable
4cx7B-4i0pB:
undetectable
4cx7A-4i0pB:
15.74
4cx7B-4i0pB:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DM BETA
CHAIN

(Homo
sapiens)
5 / 9 LEU B  51
LEU B  62
THR B  34
LEU B  33
ILE B  26
None
1.36A 4ubsA-4i0pB:
undetectable
4ubsA-4i0pB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DM BETA
CHAIN
HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO BETA
CHAIN

(Homo
sapiens)
4 / 6 HIS B 141
LEU D 180
PRO D 183
SER D 185
None
1.46A 5syjA-4i0pB:
undetectable
5syjA-4i0pB:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DM BETA
CHAIN
HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO BETA
CHAIN

(Homo
sapiens)
4 / 6 HIS B 141
LEU D 180
PRO D 183
SER D 185
None
1.46A 5syjB-4i0pB:
undetectable
5syjB-4i0pB:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO ALPHA
CHAIN

(Homo
sapiens)
3 / 3 HIS C  69
ARG C  76
ILE C  72
None
0.76A 6fgdA-4i0pC:
undetectable
6fgdA-4i0pC:
18.43