SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ALA B 193
VAL B 204
TRP B 110
 None
 0.93A 1jnoA-4i0wB:
undetectable		 1jnoA-4i0wB:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ALA B 193
VAL B 204
TRP B 110
 None
 0.93A 1jnoB-4i0wB:
undetectable		 1jnoB-4i0wB:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ALA B 193
VAL B 204
TRP B 110
 None
 0.81A 1jo3A-4i0wB:
undetectable		 1jo3A-4i0wB:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ALA B 193
VAL B 204
TRP B 110
 None
 0.81A 1jo3B-4i0wB:
undetectable		 1jo3B-4i0wB:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 4 ILE B 530
LEU B 529
VAL B 500
ALA B 191
 None
 1.01A 1mz9A-4i0wB:
undetectable		 1mz9A-4i0wB:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ALA B 193
VAL B 204
TRP B 110
 None
 0.92A 1ng8A-4i0wB:
undetectable		 1ng8A-4i0wB:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ALA B 193
VAL B 204
TRP B 110
 None
 0.92A 1ng8B-4i0wB:
undetectable		 1ng8B-4i0wB:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ALA B 193
VAL B 204
TRP B 110
 None
 0.76A 1nt6A-4i0wB:
undetectable		 1nt6A-4i0wB:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ALA B 193
VAL B 204
TRP B 110
 None
 0.75A 1nt6B-4i0wB:
undetectable		 1nt6B-4i0wB:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 7 THR B 536
ASN B 446
TYR B 445
LEU B 547
 None
 1.10A 1qzrB-4i0wB:
0.8		 1qzrB-4i0wB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 5 LEU B 547
ASP B 546
GLY B 289
VAL B 472
 None
 0.84A 2aojA-4i0wB:
undetectable		 2aojA-4i0wB:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 GLY B 194
ARG B 144
TYR B 202
 None
 0.74A 2opxA-4i0wB:
2.5		 2opxA-4i0wB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 7 ILE B 190
SER B 480
ILE B 129
PHE B 124
 None
 1.19A 2qb4A-4i0wB:
undetectable		 2qb4A-4i0wB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 7 ILE B 190
SER B 480
ILE B 210
PHE B 124
 None
 1.23A 2qb4A-4i0wB:
undetectable		 2qb4A-4i0wB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 10 ILE B 145
ARG B 144
PRO B 498
SER B 252
GLY B 189
 None
 1.35A 2qd4B-4i0wB:
undetectable		 2qd4B-4i0wB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 8 HIS B 183
SER A  96
ASP B 126
ALA B 284
 None
 1.21A 2rk8A-4i0wB:
undetectable		 2rk8A-4i0wB:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 10 PHE B 321
ASP B 370
ILE B 270
ILE B 251
GLY B 258
 None
 1.09A 2v0mA-4i0wB:
undetectable		 2v0mA-4i0wB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 8 GLY B 195
ILE B 129
VAL B 122
THR B 481
 None
 0.87A 2yoeB-4i0wB:
undetectable
2yoeC-4i0wB:
undetectable		 2yoeB-4i0wB:
22.67
2yoeC-4i0wB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 8 LYS B 526
LEU B 430
ASP B 406
GLU B 437
 EDO  B 605 (-2.7A)
None
None
EDO  B 605 (-4.6A)
 0.80A 2zw9A-4i0wB:
2.5		 2zw9A-4i0wB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 11 ASN B 250
VAL B 187
GLY B 184
ILE B 215
LEU B 253
 None
 1.30A 3bexC-4i0wB:
undetectable
3bexD-4i0wB:
undetectable		 3bexC-4i0wB:
20.92
3bexD-4i0wB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 10 LEU B 253
ASN B 250
VAL B 187
GLY B 184
ILE B 215
 None
 1.31A 3bexC-4i0wB:
undetectable
3bexD-4i0wB:
undetectable		 3bexC-4i0wB:
20.92
3bexD-4i0wB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 10 ASN B 250
VAL B 187
GLY B 184
ILE B 215
LEU B 253
 None
 1.30A 3bexE-4i0wB:
undetectable
3bexF-4i0wB:
undetectable		 3bexE-4i0wB:
20.92
3bexF-4i0wB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 11 LEU B 253
ASN B 250
VAL B 187
GLY B 184
ILE B 215
 None
 1.29A 3bexE-4i0wB:
undetectable
3bexF-4i0wB:
undetectable		 3bexE-4i0wB:
20.92
3bexF-4i0wB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 11 ASN B 250
VAL B 187
GLY B 184
ILE B 215
LEU B 253
 None
 1.33A 3bf1A-4i0wB:
undetectable
3bf1B-4i0wB:
undetectable		 3bf1A-4i0wB:
20.92
3bf1B-4i0wB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 11 ASN B 250
VAL B 187
GLY B 184
ILE B 215
LEU B 253
 None
 1.34A 3bf1C-4i0wB:
undetectable
3bf1D-4i0wB:
undetectable		 3bf1C-4i0wB:
20.92
3bf1D-4i0wB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 11 LEU B 253
ASN B 250
VAL B 187
GLY B 184
ILE B 215
 None
 1.34A 3bf1C-4i0wB:
undetectable
3bf1D-4i0wB:
undetectable		 3bf1C-4i0wB:
20.92
3bf1D-4i0wB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 11 ASN B 250
VAL B 187
GLY B 184
ILE B 215
LEU B 253
 None
 1.32A 3bf1E-4i0wB:
undetectable
3bf1F-4i0wB:
undetectable		 3bf1E-4i0wB:
20.92
3bf1F-4i0wB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 11 LEU B 253
ASN B 250
VAL B 187
GLY B 184
ILE B 215
 None
 1.36A 3bf1E-4i0wB:
undetectable
3bf1F-4i0wB:
undetectable		 3bf1E-4i0wB:
20.92
3bf1F-4i0wB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 5 LEU B 471
ASP B 470
ILE B 503
ILE B 530
 None
EDO  B 605 (-2.7A)
None
None
 0.95A 3bufA-4i0wB:
undetectable		 3bufA-4i0wB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 12 ALA B 533
ILE B 440
VAL B 204
CYH B 504
LEU B 507
 None
 1.08A 3dzuA-4i0wB:
undetectable		 3dzuA-4i0wB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 12 ILE B 379
ASN B 308
ILE B 309
SER B 388
PRO B 381
 None
 1.08A 3kpdC-4i0wB:
undetectable		 3kpdC-4i0wB:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 8 VAL B 283
CYH B 504
ILE B 281
ILE B 440
 None
 1.01A 4afgD-4i0wB:
undetectable
4afgE-4i0wB:
undetectable		 4afgD-4i0wB:
20.84
4afgE-4i0wB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 10 ILE B 215
THR B 216
ASP B 179
GLU B 177
GLY B 184
 None
 1.26A 4bwlC-4i0wB:
undetectable		 4bwlC-4i0wB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ARG B 462
THR B 429
TRP B 408
 CL  B 601 (-3.9A)
None
None
 1.18A 4d7hA-4i0wB:
undetectable		 4d7hA-4i0wB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 7 PHE B 172
ILE B 148
TYR B 157
PRO B 176
 None
 1.06A 4g5jA-4i0wB:
undetectable		 4g5jA-4i0wB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 8 LEU A  68
VAL A  51
LEU A  23
LEU A  75
 None
 1.02A 4l1xA-4i0wA:
undetectable		 4l1xA-4i0wA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 11 LEU B 318
VAL B 361
ILE B 343
ILE B 333
ILE B 377
 None
EDO  B 606 (-4.6A)
None
None
None
 0.97A 4njtA-4i0wB:
undetectable		 4njtA-4i0wB:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 12 ALA B 279
LEU B 236
ILE B 251
LEU B 229
ILE B 270
 None
 1.11A 4nx7A-4i0wB:
undetectable		 4nx7A-4i0wB:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 12 GLY B 502
LEU B 247
ILE B 190
ILE B 120
ALA B 205
 None
 1.03A 4qtuB-4i0wB:
undetectable		 4qtuB-4i0wB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 11 LEU B 318
VAL B 361
ILE B 343
ILE B 333
ILE B 377
 None
EDO  B 606 (-4.6A)
None
None
None
 0.88A 4rvjA-4i0wB:
undetectable		 4rvjA-4i0wB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 11 LEU B 318
VAL B 361
ILE B 343
ILE B 333
ILE B 377
 None
EDO  B 606 (-4.6A)
None
None
None
 0.90A 4rvjC-4i0wB:
undetectable		 4rvjC-4i0wB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ARG B 462
THR B 429
TRP B 408
 CL  B 601 (-3.9A)
None
None
 1.17A 4ug5A-4i0wB:
1.0		 4ug5A-4i0wB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ARG B 462
THR B 429
TRP B 408
 CL  B 601 (-3.9A)
None
None
 1.16A 4uglA-4i0wB:
1.1		 4uglA-4i0wB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 12 LEU A  81
LEU A  68
ARG A  77
LEU A  75
ILE A  78
 None
 1.10A 4x1fA-4i0wA:
undetectable		 4x1fA-4i0wA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 12 LEU A  81
LEU A  68
ARG A  77
LEU A  75
ILE A  78
 None
 1.11A 4x1gA-4i0wA:
undetectable		 4x1gA-4i0wA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 7 GLY B 189
ARG B 144
GLY B 194
ALA B 191
 None
 0.72A 5e26A-4i0wB:
1.9
5e26B-4i0wB:
undetectable		 5e26A-4i0wB:
23.89
5e26B-4i0wB:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 7 ALA B 191
GLY B 189
ARG B 144
GLY B 194
 None
 0.75A 5e26A-4i0wB:
1.9
5e26B-4i0wB:
undetectable		 5e26A-4i0wB:
23.89
5e26B-4i0wB:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 7 GLY B 189
ARG B 144
GLY B 194
ALA B 191
 None
 0.71A 5e26C-4i0wB:
undetectable
5e26D-4i0wB:
undetectable		 5e26C-4i0wB:
23.89
5e26D-4i0wB:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 8 ALA B 191
GLY B 189
ARG B 144
GLY B 194
 None
 0.73A 5e26C-4i0wB:
undetectable
5e26D-4i0wB:
undetectable		 5e26C-4i0wB:
23.89
5e26D-4i0wB:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ARG B 462
THR B 429
TRP B 408
 CL  B 601 (-3.9A)
None
None
 1.20A 5g6cA-4i0wB:
undetectable		 5g6cA-4i0wB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 12 ILE B 215
ALA B 496
ALA B 497
VAL B 283
GLY B 492
 None
 1.31A 5igpA-4i0wB:
undetectable		 5igpA-4i0wB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 12 VAL B 122
ALA B 284
VAL B 187
GLY B 189
ALA B 188
 None
 1.06A 5kirB-4i0wB:
undetectable		 5kirB-4i0wB:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 10 VAL B 439
THR B 274
ILE B 281
LEU B 233
PHE B 273
 None
 1.08A 5mxbA-4i0wB:
undetectable		 5mxbA-4i0wB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		5 / 10 PRO B 469
GLY B 286
GLY B 457
VAL B 472
THR B 493
 None
 0.98A 5o96G-4i0wB:
2.9
5o96H-4i0wB:
3.1		 5o96G-4i0wB:
20.37
5o96H-4i0wB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 8 THR B 132
TYR B 131
THR B 143
ARG B 144
 None
 1.42A 5tzoB-4i0wB:
undetectable		 5tzoB-4i0wB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		3 / 3 ILE B 210
ASN B 250
CYH B 504
 None
 0.76A 6bp4A-4i0wB:
undetectable		 6bp4A-4i0wB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 7 ASP B 370
GLN B 372
SER B 263
GLY B 262
 None
 0.87A 6ekzA-4i0wB:
undetectable		 6ekzA-4i0wB:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 4i0w PROTEASE CSPB
(Clostridium
perfringens) 		4 / 7 GLY B 184
PHE B 124
VAL B 213
SER B 252
 None
 0.91A 6hu9S-4i0wB:
undetectable
6hu9q-4i0wB:
undetectable		 6hu9S-4i0wB:
12.06
6hu9q-4i0wB:
14.68