SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i0x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 4i0x ESAT-6-LIKE PROTEIN
MAB_3112
ESAT-6-LIKE PROTEIN
MAB_3113
(Mycobacteroides
abscessus) 		4 / 7 GLU B  71
LEU B  72
VAL B  30
LEU A  62
 None
 0.83A 1hk3A-4i0xB:
2.6		 1hk3A-4i0xB:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4i0x ESAT-6-LIKE PROTEIN
MAB_3112
ESAT-6-LIKE PROTEIN
MAB_3113
(Mycobacteroides
abscessus) 		4 / 5 ASP A   2
LEU A   7
GLY A   5
ARG B  40
 None
 1.21A 2j2pA-4i0xA:
undetectable
2j2pB-4i0xA:
undetectable		 2j2pA-4i0xA:
16.06
2j2pB-4i0xA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 4i0x ESAT-6-LIKE PROTEIN
MAB_3112
ESAT-6-LIKE PROTEIN
MAB_3113
(Mycobacteroides
abscessus) 		4 / 4 ASP A   2
LEU A   7
GLY A   5
ARG B  40
 None
 1.26A 2j2pD-4i0xA:
undetectable
2j2pE-4i0xA:
undetectable		 2j2pD-4i0xA:
16.06
2j2pE-4i0xA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4i0x ESAT-6-LIKE PROTEIN
MAB_3112
ESAT-6-LIKE PROTEIN
MAB_3113
(Mycobacteroides
abscessus) 		5 / 12 ALA B  41
GLN B  42
LEU A  62
THR A  68
PHE A  76
 None
 1.44A 2oaxC-4i0xB:
undetectable		 2oaxC-4i0xB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4i0x ESAT-6-LIKE PROTEIN
MAB_3112
ESAT-6-LIKE PROTEIN
MAB_3113
(Mycobacteroides
abscessus) 		5 / 12 ALA B  41
GLN B  42
LEU A  62
THR A  68
PHE A  76
 None
 1.47A 3vhuA-4i0xB:
undetectable		 3vhuA-4i0xB:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4i0x ESAT-6-LIKE PROTEIN
MAB_3112
ESAT-6-LIKE PROTEIN
MAB_3113
(Mycobacteroides
abscessus;
Mycobacteroides
abscessus) 		4 / 6 LEU A  62
ILE A  65
LEU B  37
GLU B  38
 None
 0.96A 4w5nA-4i0xA:
undetectable		 4w5nA-4i0xA:
8.24