SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  19
LEU A 190
ARG A   9
ILE A  23
HIS A 144
 None
None
None
None
SO4  A 502 (-4.0A)
 1.50A 1ereD-4i14A:
undetectable		 1ereD-4i14A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 349
ASP A 370
GLY A 344
LEU A 348
ILE A 209
 None
 1.24A 1sq5D-4i14A:
undetectable		 1sq5D-4i14A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		5 / 12 CYH A 164
PRO A  60
ILE A 166
ILE A  35
LEU A 190
 None
 1.20A 1z9hD-4i14A:
undetectable		 1z9hD-4i14A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 181
THR A 178
ILE A  35
HIS A 144
 None
None
None
SO4  A 502 (-4.0A)
 1.27A 2jfaB-4i14A:
undetectable		 2jfaB-4i14A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 105
THR A  53
VAL A  50
 None
 0.95A 2q64A-4i14A:
undetectable		 2q64A-4i14A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		4 / 6 ILE A  96
ARG A 110
MET A 109
VAL A 167
 None
 1.13A 2ygoA-4i14A:
undetectable		 2ygoA-4i14A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_A_AZMA263_1
(CARBONIC ANHYDRASE 9)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 206
VAL A  11
VAL A  20
LEU A 198
TRP A 201
 None
 1.20A 3iaiA-4i14A:
undetectable		 3iaiA-4i14A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_B_AZMB263_1
(CARBONIC ANHYDRASE 9)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 206
VAL A  11
VAL A  20
LEU A 198
TRP A 201
 None
 1.20A 3iaiB-4i14A:
undetectable		 3iaiB-4i14A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_C_AZMC263_1
(CARBONIC ANHYDRASE 9)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 206
VAL A  11
VAL A  20
LEU A 198
TRP A 201
 None
 1.21A 3iaiC-4i14A:
undetectable		 3iaiC-4i14A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_D_AZMD263_1
(CARBONIC ANHYDRASE 9)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 206
VAL A  11
VAL A  20
LEU A 198
TRP A 201
 None
 1.19A 3iaiD-4i14A:
undetectable		 3iaiD-4i14A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 271
ASP A 268
GLY A 278
VAL A 269
HIS A 261
 None
 1.42A 4c5lA-4i14A:
undetectable		 4c5lA-4i14A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 271
ASP A 268
GLY A 278
VAL A 269
HIS A 261
 None
 1.41A 4c5lC-4i14A:
2.2		 4c5lC-4i14A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		5 / 7 GLY A 271
ASP A 268
GLY A 278
VAL A 269
HIS A 261
 None
 1.46A 4c5nA-4i14A:
undetectable		 4c5nA-4i14A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 143
GLU A 146
ASP A  33
ASP A  25
 SO4  A 502 (-3.2A)
SO4  A 502 (-4.4A)
None
None
 0.89A 4uckB-4i14A:
undetectable		 4uckB-4i14A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Mycobacterium
tuberculosis) 		4 / 6 THR A   2
ARG A   3
LEU A   4
ASP A   5
 None
 0.96A 5tdzA-4i14A:
undetectable		 5tdzA-4i14A:
22.87