SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.21A 1gtnL-4i15A:
undetectable
1gtnM-4i15A:
undetectable		 1gtnL-4i15A:
12.79
1gtnM-4i15A:
12.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
VAL A 840
GLN A 874
PHE A 877
 None
 0.67A 1udtA-4i15A:
37.2		 1udtA-4i15A:
31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 10 TYR A 668
HIS A 669
PHE A 844
GLN A 874
GLY A 876
PHE A 877
 None
 0.70A 1uhoA-4i15A:
37.0		 1uhoA-4i15A:
31.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.22A 1utdG-4i15A:
undetectable
1utdH-4i15A:
undetectable		 1utdG-4i15A:
12.79
1utdH-4i15A:
12.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
HIS A 713
MET A 785
ASN A 825
GLN A 874
 None
 0.67A 1xlxA-4i15A:
38.9		 1xlxA-4i15A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
HIS A 713
MET A 785
ASN A 825
PHE A 877
 None
 0.52A 1xlxA-4i15A:
38.9		 1xlxA-4i15A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
HIS A 713
MET A 785
THR A 841
 None
 1.45A 1xlxA-4i15A:
38.9		 1xlxA-4i15A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		8 / 12 TYR A 668
HIS A 669
HIS A 713
MET A 785
PHE A 844
MET A 861
GLN A 874
PHE A 877
 None
 0.84A 1xlxB-4i15A:
38.8		 1xlxB-4i15A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
ASP A 822
TRP A 836
PHE A 844
PHE A 877
 None
None
ZN  A1001 (-2.5A)
None
None
None
 0.49A 1xmuA-4i15A:
39.0		 1xmuA-4i15A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 822
TRP A 836
PHE A 844
 None
None
None
ZN  A1001 (-2.5A)
None
None
 0.35A 1xmuB-4i15A:
38.9		 1xmuB-4i15A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		8 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 822
PHE A 844
MET A 861
GLN A 874
PHE A 877
 None
None
None
ZN  A1001 (-2.5A)
None
None
None
None
 0.87A 1xomA-4i15A:
38.7		 1xomA-4i15A:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		7 / 12 TYR A 668
HIS A 669
MET A 785
PHE A 844
MET A 861
GLN A 874
PHE A 877
 None
 0.93A 1xomB-4i15A:
38.6		 1xomB-4i15A:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 822
PHE A 877
 None
None
None
ZN  A1001 (-2.5A)
None
 0.45A 1xoqA-4i15A:
38.8		 1xoqA-4i15A:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		3 / 3 ASN A 825
TRP A 836
GLN A 874
 None
 0.33A 1xoqA-4i15A:
38.8		 1xoqA-4i15A:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
ASP A 822
TRP A 836
PHE A 877
 None
None
ZN  A1001 (-2.5A)
None
None
 0.47A 1xoqB-4i15A:
38.6		 1xoqB-4i15A:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		3 / 3 MET A 785
ASN A 825
GLN A 874
 None
 0.69A 1xoqB-4i15A:
38.7		 1xoqB-4i15A:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		8 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 822
PHE A 844
MET A 861
GLN A 874
PHE A 877
 None
None
None
ZN  A1001 (-2.5A)
None
None
None
None
 0.87A 1xosA-4i15A:
38.8		 1xosA-4i15A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
MET A 785
GLN A 874
PHE A 877
 None
 0.64A 1xotA-4i15A:
38.6		 1xotA-4i15A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 12 TYR A 668
MET A 785
MET A 861
GLN A 874
PHE A 877
 None
 1.00A 1xotA-4i15A:
38.6		 1xotA-4i15A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		7 / 12 TYR A 668
HIS A 669
MET A 785
ASN A 825
MET A 861
GLN A 874
PHE A 877
 None
 0.88A 1xotB-4i15A:
38.9		 1xotB-4i15A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 12 TYR A 668
VAL A 840
PHE A 844
GLN A 874
PHE A 877
 None
 0.61A 1xozA-4i15A:
39.5		 1xozA-4i15A:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 11 TYR A 668
HIS A 669
VAL A 840
PHE A 844
GLN A 874
PHE A 877
 None
 0.77A 2h42A-4i15A:
37.3		 2h42A-4i15A:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
VAL A 840
GLN A 874
PHE A 877
 None
 0.66A 2h42B-4i15A:
37.1		 2h42B-4i15A:
31.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		4 / 5 LEU A 894
VAL A 675
LEU A 707
ARG A 634
 None
 1.06A 2oiqA-4i15A:
undetectable		 2oiqA-4i15A:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
GLU A 843
PHE A 844
GLN A 874
PHE A 877
 None
 0.72A 2weyA-4i15A:
38.2		 2weyA-4i15A:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		7 / 12 TYR A 668
HIS A 669
VAL A 826
GLU A 843
PHE A 844
MET A 861
PHE A 877
 None
 0.67A 2weyA-4i15A:
38.2		 2weyA-4i15A:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		4 / 8 VAL A 826
PHE A 844
MET A 861
PHE A 877
 None
 0.71A 2weyB-4i15A:
38.4		 2weyB-4i15A:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
VAL A 840
PHE A 844
GLN A 874
PHE A 877
 None
 0.63A 3b2rA-4i15A:
32.7		 3b2rA-4i15A:
31.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 11 TYR A 668
HIS A 669
VAL A 840
GLN A 874
PHE A 877
 None
 0.59A 3b2rB-4i15A:
32.5		 3b2rB-4i15A:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 ASP A 710
ILE A 681
GLY A 821
ILE A 823
VAL A 780
 MG  A1002 ( 2.6A)
None
None
None
None
 1.30A 3ekyB-4i15A:
undetectable		 3ekyB-4i15A:
13.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
MET A 785
ASN A 825
TRP A 836
PHE A 877
 None
 0.44A 3g4lA-4i15A:
38.2		 3g4lA-4i15A:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 822
THR A 841
 None
None
None
ZN  A1001 (-2.5A)
None
 1.38A 3g4lB-4i15A:
38.2		 3g4lB-4i15A:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 822
TRP A 836
PHE A 877
 None
None
None
ZN  A1001 (-2.5A)
None
None
 0.46A 3g4lB-4i15A:
38.2		 3g4lB-4i15A:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 822
ASN A 825
TRP A 836
 None
None
None
ZN  A1001 (-2.5A)
None
None
 0.39A 3g4lC-4i15A:
38.2		 3g4lC-4i15A:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 822
THR A 841
 None
None
None
ZN  A1001 (-2.5A)
None
 1.39A 3g4lC-4i15A:
38.2		 3g4lC-4i15A:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 822
THR A 841
 None
None
None
ZN  A1001 (-2.5A)
None
 1.40A 3g4lD-4i15A:
38.5		 3g4lD-4i15A:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 822
TRP A 836
GLN A 874
 None
None
None
ZN  A1001 (-2.5A)
None
None
 0.50A 3g4lD-4i15A:
38.5		 3g4lD-4i15A:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 9 TYR A 668
MET A 785
ASN A 825
PHE A 844
GLN A 874
PHE A 877
 None
 0.84A 3iakA-4i15A:
38.1		 3iakA-4i15A:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 9 TYR A 668
MET A 785
ASN A 825
PHE A 844
MET A 861
PHE A 877
 None
 0.88A 3iakA-4i15A:
38.1		 3iakA-4i15A:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 11 MET A 776
LEU A 636
LEU A 707
VAL A 708
ILE A 681
 None
 1.25A 3jw5A-4i15A:
undetectable		 3jw5A-4i15A:
18.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		7 / 9 TYR A 668
HIS A 669
VAL A 840
LEU A 870
GLN A 874
PHE A 877
VAL A 881
 None
 0.69A 3jwqA-4i15A:
39.4		 3jwqA-4i15A:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 9 TYR A 668
HIS A 669
VAL A 840
MET A 861
PHE A 877
VAL A 881
 None
 0.65A 3jwqA-4i15A:
39.4		 3jwqA-4i15A:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 11 HIS A 669
ASN A 717
VAL A 840
MET A 861
PHE A 877
 None
 0.73A 3jwqB-4i15A:
39.5
3jwqC-4i15A:
39.3		 3jwqB-4i15A:
32.96
3jwqC-4i15A:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 11 TYR A 668
HIS A 669
VAL A 840
LEU A 870
GLN A 874
PHE A 877
 None
 0.76A 3jwqB-4i15A:
39.5
3jwqC-4i15A:
39.3		 3jwqB-4i15A:
32.96
3jwqC-4i15A:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 11 TYR A 668
HIS A 669
VAL A 840
MET A 861
GLN A 874
PHE A 877
 None
 0.73A 3jwqB-4i15A:
39.5
3jwqC-4i15A:
39.3		 3jwqB-4i15A:
32.96
3jwqC-4i15A:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		6 / 7 TYR A 668
HIS A 669
LEU A 870
GLN A 874
PHE A 877
VAL A 881
 None
 0.66A 3jwqC-4i15A:
39.3		 3jwqC-4i15A:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 7 TYR A 668
HIS A 669
MET A 861
PHE A 877
VAL A 881
 None
 0.63A 3jwqC-4i15A:
39.3		 3jwqC-4i15A:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 11 TYR A 668
HIS A 669
MET A 861
GLN A 874
PHE A 877
 None
 0.88A 3jwqA-4i15A:
39.4
3jwqD-4i15A:
39.0		 3jwqA-4i15A:
32.96
3jwqD-4i15A:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 11 TYR A 668
HIS A 669
PHE A 844
MET A 861
PHE A 877
 None
 0.58A 3jwqA-4i15A:
39.4
3jwqD-4i15A:
39.0		 3jwqA-4i15A:
32.96
3jwqD-4i15A:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 7 TYR A 668
ASN A 825
PHE A 844
GLN A 874
PHE A 877
 None
 0.86A 3tvxB-4i15A:
38.9		 3tvxB-4i15A:
31.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 7 TYR A 668
ASN A 825
PHE A 844
MET A 861
PHE A 877
 None
 0.69A 3tvxB-4i15A:
38.9		 3tvxB-4i15A:
31.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.27A 5eeuA-4i15A:
undetectable
5eeuB-4i15A:
undetectable		 5eeuA-4i15A:
12.79
5eeuB-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5eeuB-4i15A:
undetectable
5eeuC-4i15A:
undetectable		 5eeuB-4i15A:
12.79
5eeuC-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5eeuE-4i15A:
undetectable
5eeuF-4i15A:
undetectable		 5eeuE-4i15A:
12.79
5eeuF-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.19A 5eeuG-4i15A:
undetectable
5eeuH-4i15A:
undetectable		 5eeuG-4i15A:
12.79
5eeuH-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.19A 5eeuS-4i15A:
undetectable
5eeuT-4i15A:
undetectable		 5eeuS-4i15A:
12.79
5eeuT-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.22A 5eeuT-4i15A:
undetectable
5eeuU-4i15A:
undetectable		 5eeuT-4i15A:
12.79
5eeuU-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5eevB-4i15A:
undetectable
5eevC-4i15A:
undetectable		 5eevB-4i15A:
12.79
5eevC-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.27A 5eevD-4i15A:
undetectable
5eevE-4i15A:
undetectable		 5eevD-4i15A:
12.79
5eevE-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5eevE-4i15A:
undetectable
5eevF-4i15A:
undetectable		 5eevE-4i15A:
12.79
5eevF-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.19A 5eevG-4i15A:
undetectable
5eevH-4i15A:
undetectable		 5eevG-4i15A:
12.79
5eevH-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.20A 5eevS-4i15A:
undetectable
5eevT-4i15A:
undetectable		 5eevS-4i15A:
12.79
5eevT-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.22A 5eevT-4i15A:
undetectable
5eevU-4i15A:
undetectable		 5eevT-4i15A:
12.79
5eevU-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5eewB-4i15A:
undetectable
5eewC-4i15A:
undetectable		 5eewB-4i15A:
12.79
5eewC-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.27A 5eewD-4i15A:
undetectable
5eewE-4i15A:
undetectable		 5eewD-4i15A:
12.79
5eewE-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5eewE-4i15A:
undetectable
5eewF-4i15A:
undetectable		 5eewE-4i15A:
12.79
5eewF-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.19A 5eewG-4i15A:
undetectable
5eewH-4i15A:
undetectable		 5eewG-4i15A:
12.79
5eewH-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.20A 5eewS-4i15A:
undetectable
5eewT-4i15A:
undetectable		 5eewS-4i15A:
12.79
5eewT-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.22A 5eewT-4i15A:
undetectable
5eewU-4i15A:
undetectable		 5eewT-4i15A:
12.79
5eewU-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5eexB-4i15A:
undetectable
5eexC-4i15A:
undetectable		 5eexB-4i15A:
12.79
5eexC-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5eexE-4i15A:
undetectable
5eexF-4i15A:
undetectable		 5eexE-4i15A:
12.79
5eexF-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.18A 5eexG-4i15A:
undetectable
5eexH-4i15A:
undetectable		 5eexG-4i15A:
12.79
5eexH-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.20A 5eexS-4i15A:
undetectable
5eexT-4i15A:
undetectable		 5eexS-4i15A:
12.79
5eexT-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.22A 5eexT-4i15A:
undetectable
5eexU-4i15A:
undetectable		 5eexT-4i15A:
12.79
5eexU-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5eeyB-4i15A:
undetectable
5eeyC-4i15A:
undetectable		 5eeyB-4i15A:
12.79
5eeyC-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5eeyE-4i15A:
undetectable
5eeyF-4i15A:
undetectable		 5eeyE-4i15A:
12.79
5eeyF-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.19A 5eeyG-4i15A:
undetectable
5eeyH-4i15A:
undetectable		 5eeyG-4i15A:
12.79
5eeyH-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.20A 5eeyS-4i15A:
undetectable
5eeyT-4i15A:
undetectable		 5eeyS-4i15A:
12.79
5eeyT-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.22A 5eeyT-4i15A:
undetectable
5eeyU-4i15A:
undetectable		 5eeyT-4i15A:
12.79
5eeyU-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5eezB-4i15A:
undetectable
5eezC-4i15A:
undetectable		 5eezB-4i15A:
12.79
5eezC-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5eezE-4i15A:
undetectable
5eezF-4i15A:
undetectable		 5eezE-4i15A:
12.79
5eezF-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.19A 5eezG-4i15A:
undetectable
5eezH-4i15A:
undetectable		 5eezG-4i15A:
12.79
5eezH-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.20A 5eezS-4i15A:
undetectable
5eezT-4i15A:
undetectable		 5eezS-4i15A:
12.79
5eezT-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.23A 5eezT-4i15A:
undetectable
5eezU-4i15A:
undetectable		 5eezT-4i15A:
12.79
5eezU-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5ef0B-4i15A:
undetectable
5ef0C-4i15A:
undetectable		 5ef0B-4i15A:
12.79
5ef0C-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5ef0E-4i15A:
undetectable
5ef0F-4i15A:
undetectable		 5ef0E-4i15A:
12.79
5ef0F-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.19A 5ef0G-4i15A:
undetectable
5ef0H-4i15A:
undetectable		 5ef0G-4i15A:
12.79
5ef0H-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.20A 5ef0S-4i15A:
undetectable
5ef0T-4i15A:
undetectable		 5ef0S-4i15A:
12.79
5ef0T-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.23A 5ef0T-4i15A:
undetectable
5ef0U-4i15A:
undetectable		 5ef0T-4i15A:
12.79
5ef0U-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.22A 5ef1B-4i15A:
undetectable
5ef1C-4i15A:
undetectable		 5ef1B-4i15A:
12.79
5ef1C-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.23A 5ef1E-4i15A:
undetectable
5ef1F-4i15A:
undetectable		 5ef1E-4i15A:
12.79
5ef1F-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.19A 5ef1G-4i15A:
undetectable
5ef1H-4i15A:
undetectable		 5ef1G-4i15A:
12.79
5ef1H-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.20A 5ef1S-4i15A:
undetectable
5ef1T-4i15A:
undetectable		 5ef1S-4i15A:
12.79
5ef1T-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.22A 5ef1T-4i15A:
undetectable
5ef1U-4i15A:
undetectable		 5ef1T-4i15A:
12.79
5ef1U-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.22A 5ef2B-4i15A:
undetectable
5ef2C-4i15A:
undetectable		 5ef2B-4i15A:
12.79
5ef2C-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.22A 5ef2E-4i15A:
undetectable
5ef2F-4i15A:
undetectable		 5ef2E-4i15A:
12.79
5ef2F-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.18A 5ef2G-4i15A:
undetectable
5ef2H-4i15A:
undetectable		 5ef2G-4i15A:
12.79
5ef2H-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.20A 5ef2S-4i15A:
undetectable
5ef2T-4i15A:
undetectable		 5ef2S-4i15A:
12.79
5ef2T-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.23A 5ef2T-4i15A:
undetectable
5ef2U-4i15A:
undetectable		 5ef2T-4i15A:
12.79
5ef2U-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.22A 5ef3B-4i15A:
undetectable
5ef3C-4i15A:
undetectable		 5ef3B-4i15A:
12.79
5ef3C-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.27A 5ef3D-4i15A:
undetectable
5ef3E-4i15A:
undetectable		 5ef3D-4i15A:
12.79
5ef3E-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 9 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.22A 5ef3E-4i15A:
undetectable
5ef3F-4i15A:
undetectable		 5ef3E-4i15A:
12.79
5ef3F-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 THR A 900
SER A 824
ALA A 820
THR A 680
ILE A 817
 None
 1.18A 5ef3G-4i15A:
undetectable
5ef3H-4i15A:
undetectable		 5ef3G-4i15A:
12.79
5ef3H-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.20A 5ef3S-4i15A:
undetectable
5ef3T-4i15A:
undetectable		 5ef3S-4i15A:
12.79
5ef3T-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 10 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.23A 5ef3T-4i15A:
undetectable
5ef3U-4i15A:
undetectable		 5ef3T-4i15A:
12.79
5ef3U-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 8 GLU A 843
VAL A 666
HIS A 669
ASP A 710
HIS A 745
 None
None
None
MG  A1002 ( 2.6A)
None
 1.28A 5f8yA-4i15A:
undetectable		 5f8yA-4i15A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		5 / 8 GLU A 843
VAL A 666
HIS A 669
ASP A 710
HIS A 745
 None
None
None
MG  A1002 ( 2.6A)
None
 1.31A 5f8yB-4i15A:
undetectable		 5f8yB-4i15A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		4 / 5 GLY A 763
ASP A 762
ARG A 769
MET A 814
 None
 1.12A 5gwkA-4i15A:
undetectable		 5gwkA-4i15A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		4 / 8 PHE A 885
ILE A 889
LEU A 702
LEU A 685
 None
 0.76A 5hs1A-4i15A:
undetectable		 5hs1A-4i15A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1
(Trypanosoma
brucei) 		4 / 8 HIS A 682
TYR A 686
LEU A 703
LEU A 635
 None
 1.13A 5hs6A-4i15A:
undetectable		 5hs6A-4i15A:
19.60