SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i1f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4i1f E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Homo
sapiens) 		4 / 6 PHE A 208
HIS A 461
VAL A 465
PHE A 210
 None
ZN  A 508 (-3.2A)
None
None
 1.08A 4a97E-4i1fA:
undetectable		 4a97E-4i1fA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 4i1f E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Homo
sapiens) 		4 / 5 LEU A 176
ASP A 185
ARG A 191
ILE A 188
 None
 1.46A 4mwrA-4i1fA:
undetectable		 4mwrA-4i1fA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4i1f E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Homo
sapiens) 		3 / 3 VAL A 164
ALA A 172
PHE A 209
 None
 0.91A 4z4iA-4i1fA:
undetectable		 4z4iA-4i1fA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4i1f E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Homo
sapiens) 		3 / 3 GLY A 152
CYH A 150
CYH A 154
 None
ZN  A 501 (-2.2A)
ZN  A 501 (-2.3A)
 0.92A 5inzB-4i1fA:
undetectable		 5inzB-4i1fA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4i1f E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Homo
sapiens) 		3 / 3 VAL A 164
ALA A 172
PHE A 209
 None
 0.91A 5js1A-4i1fA:
undetectable		 5js1A-4i1fA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4i1f E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Homo
sapiens) 		3 / 3 ALA A 390
GLN A 276
THR A 270
 None
 0.70A 5n0oA-4i1fA:
undetectable		 5n0oA-4i1fA:
21.01